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Polymorphism in the mitochondrial cytochrome B gene in Koreans

An additional marker for individual identification

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Abstract

Sequencing the mitochondrial control region is very useful for individual identification when conventional DNA typing using autosomal STRs is unavailable. However, low discriminatory power is a problem and another polymorphic locus within the mitochondrial genome is necessary. The cytochrome B (MTCYB) gene, which has undergone several changes during evolution, may be a good candidate for this purpose. Here the sequencing data of the MTCYB gene of 98 unrelated Koreans is presented. A total of 30 polymorphic sites were found which were distributed evenly along the gene. All were nucleotide substitutions and no insertions/deletions were noted. A total of 22 different MTCYB lineages were revealed. Out of 22 different control region lineages with 79 samples which shared the same D-loop sequence with some others within a lineage, 10 lineages with 37 samples could be sub-grouped according to different MTCYB sequences. Some issues concerning the MTCYB gene polymorphism are discussed.

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Authors and Affiliations

  1. Department of Forensic Medicine, Seoul National University College of Medicine, 28 Yeongon-dong, Chongno-gu, 110-799, Seoul, Korea

    Soong Deok Lee, Yoon Seong Lee & Jung Bin Lee

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  1. Soong Deok Lee
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  2. Yoon Seong Lee
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  3. Jung Bin Lee
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Correspondence to Soong Deok Lee.

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Electronic supplementary material to this paper can be obtained by using the Springer Link server located at http://dx.doi.org/10.1007/

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Lee, S.D., Lee, Y.S. & Lee, J.B. Polymorphism in the mitochondrial cytochrome B gene in Koreans. Int J Legal Med 116, 74–78 (2002). https://doi.org/10.1007/s004140100238

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  • DOI: https://doi.org/10.1007/s004140100238

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