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New reference allelic ladders to improve allelic designation in a multiplex STR system

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Abstract

This paper reports the composition of a new reference allelic ladder mixture for use with a multiplex DNA profiling system consisting of six short tandem repeat loci. The loci included in this mixture are HUMTH01, D21S11, D18S51, D8S1179, HUMVWAF31/A, HUMFIBRA/FGA and an amelogenin sex test. Sequence analysis of individual ladder alleles was carried out and allelic designations made in accordance with the recommendations of the International Society of Forensic Haemogenetics (1992; 1994). A series of rare alleles which increase the range of alleles previously reported were identified. By including some of the rare alleles into the ladder marker system, we have significantly improved the ability to identify new alleles in unknown samples.

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Authors and Affiliations

  1. Forensic Science Service, Priory House, Gooch Street North, Birmingham B5 6QQ, UK FAX: +44 121 622 2051, , , , , , GB

    R. A. L. Griffiths, M. D. Barber, P. E. Johnson, S. M. Gillbard, M. D. Haywood, C. D. Smith, J. Arnold, T. Burke, A. J. Urquhart & P. Gill

Authors
  1. R. A. L. Griffiths
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  2. M. D. Barber
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  3. P. E. Johnson
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  4. S. M. Gillbard
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  5. M. D. Haywood
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  6. C. D. Smith
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  7. J. Arnold
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  8. T. Burke
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  9. A. J. Urquhart
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  10. P. Gill
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Additional information

Received: 12 August 1997 / Received in revised form: 7 November 1997

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Griffiths, R., Barber, M., Johnson, P. et al. New reference allelic ladders to improve allelic designation in a multiplex STR system. Int J Leg Med 111, 267–272 (1998). https://doi.org/10.1007/s004140050167

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  • DOI: https://doi.org/10.1007/s004140050167

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