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Forensic characteristics and genetic structure of 18 autosomal STR loci in the Sierra Leone population

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Abstract

Population genetic analysis is of vital importance for personal identification and paternity testing in forensic science. However, the forensic characteristics of autosomal short tandem repeat (STR) loci in the Sierra Leone population have not been reported yet to the best of our knowledge. In this study, 528 unrelated individuals (256 males and 272 females) in Sierra Leone, West Africa, were genotyped using the DNA Typer19™ kit; forensic parameters and genetic relationships with 32 populations around the world were analyzed. A total of 239 alleles were detected, with corresponding allele frequencies ranged from 0.0009 to 0.4545. The cumulative power of discrimination (CPD) value of the 18 STR loci was 0.9999999999999999999999697; the cumulative probability of exclusion for duos (CPE duos) and exclusion for trios (CPE trios) were 0.99999343 and 0.9999999895, respectively. Genetic comparisons showed that the Sierra Leone population has a closer genetic relationship with the Bantu-speaking populations in Sub-Saharan Africa.

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Funding

This project was supported by the National Natural Science Foundation of China (NSFC, no. 81871533), the Natural Science Foundation of Hunan Province (No. 2020JJ4779), and Postdoctoral Science Foundation of Central South University (229795).

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Authors and Affiliations

  1. Department of Forensic Science, School of Basic Medical Sciences, Central South University, No 172. Tongzipo Road, Changsha, 410013, Hunan, People’s Republic of China

    Jienan Li & Lagabaiyila Zha

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  1. Jienan Li
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  2. Lagabaiyila Zha
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Correspondence to Lagabaiyila Zha.

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The study was approved by the Grey Bush Community Health Center (2019-056), and written informed consent from each participant.

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The authors declare that they have no conflicts of interest.

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Li, J., Zha, L. Forensic characteristics and genetic structure of 18 autosomal STR loci in the Sierra Leone population. Int J Legal Med 135, 455–456 (2021). https://doi.org/10.1007/s00414-020-02487-7

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  • DOI: https://doi.org/10.1007/s00414-020-02487-7

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