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Myoglobinemia markers with potential applications in forensic sample analysis: lipid markers in myoglobinemia for postmortem blood

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Abstract

The crush syndrome, in which rhabdomyolysis and trauma occur as a result of heat stroke and drug intoxication, can lead to myoglobinemia. This condition can be diagnosed by measuring myoglobin (Mb) levels in blood and urine. However, postmortem Mb levels are unreliable indicators, since blood Mb concentration drastically increases within a very short time after death and urine cannot always be obtained at dissection; this makes it difficult to diagnose myoglobinemia in a corpse. To address this issue, in this study, we used a lipidomics approach to identify markers that can be used to detect myoglobinemia in postmortem blood samples. We found that increases in levels of fatty acid oxides such as stearic, oleic, linoleic, and arachidonic acid and decreases in levels of plasmalogens and phosphatidylethanolamine in the blood were associated with high Mb level. These results demonstrate that postmortem samples are amenable to lipidomics analysis and provide a set of markers other than Mb that can be used for postmortem diagnosis of myoglobinemia.

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Authors and Affiliations

  1. Department of Legal Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba Prefecture, 260-8670, Japan

    Hiroko Abe, Daisuke Yajima, Yumi Hoshioka, Sayaka Nagasawa & Hirotaro Iwase

  2. Division of Legal Medicine, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan

    Akina Nara

  3. Department of Forensic Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

    Hirotaro Iwase

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  1. Hiroko Abe
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  2. Daisuke Yajima
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  3. Yumi Hoshioka
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  4. Akina Nara
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  5. Sayaka Nagasawa
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  6. Hirotaro Iwase
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Correspondence to Hiroko Abe.

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Abe, H., Yajima, D., Hoshioka, Y. et al. Myoglobinemia markers with potential applications in forensic sample analysis: lipid markers in myoglobinemia for postmortem blood. Int J Legal Med 131, 1739–1746 (2017). https://doi.org/10.1007/s00414-017-1657-8

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  • DOI: https://doi.org/10.1007/s00414-017-1657-8

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