Abstract
In a mother-child pair, false exclusions in markers on chromosome 6 have been observed. The genetic incompatibilities have been caused by paternal uniparental disomy. The consequences of such cases for investigations of parentage are discussed.
References
Bein G, Driller B, Schürmann M, Schneider PM, Kirchner H (1998) Pseudo-exclusion from paternity due to maternal uniparental disomy 16. Int J Legal Med 111:328–330
Brinkmann B, Klintschar M, Neuhuber F, Hühne J, Rolf B (1998) Mutation rate in human microsatellites: influence of the structure and length of the tandem repeat. Am J Hum Genet 62:1408–1415
Brinkmann B, Pfeiffer H, Schürenkamp M, Hohoff C (2001) The evidential value of STRs. An analysis of exclusion cases. Int J Legal Med 114:173–177
Dauber EM, Glock B, Mayr D, Mayr WR (1999) A case of dispermic chimerism: importance of DNA polymorphisms. J Biol Regul Homeost Agents 13:51–53
Engel E (1980) A new genetic concept: uniparental disomy and its potential effect, isodisomy. Am J Med Genet 6:137–143
Engel E, Antonarakis SE (2002) Genomic imprinting and uniparental disomy in medicine. Wiley-Liss, New York, NY, USA
Gunzer C, Dauber EM, Petrasek M, Glock B, Schwartz DWM, Mayr WR (2004) Apparent exclusion of maternity in a twin chimera carrying only her twin brother’s blood cells. Vox Sang 87[Suppl 3]:130
Heinrich M, Müller M, Rand S, Brinkmann B, Hohoff C (2004) Allelic drop-out in the STR system ACTBP2 (SE33) as a result of mutations in the primer binding region. Int J Legal Med 118:361–363
Konjhodzic R, Kubat M, Skavic J (2004) Bosnian population data for the 15 STR loci in the Power Plex 16 kit. Int J Legal Med 118:119–121
Kubat M, Skavic J, Behluli I, Nuraj B, Bekteshi T, Behluli M, Martinovic Klaric I, Pericic M (2004) Population genetics of the 15 AmpFlSTR Identifiler loci in Kosovo Albanians. Int J Legal Med 118:115–118
Mayr WR (1981) Human chimerism. Rev Fr Transfus Immunohematol 24:19–26
Mayr WR, Pausch V, Schnedl W (1979) Human chimera detectable only by investigation of her progeny. Nature 277:210–211
Milde A, Kühl-Burmeister R, Ritz-Timme S, Kaatsch HJ (1999) DNA typing in cases of blood chimerism. Int J Legal Med 112:333–335
Polymeropoulos MH, Rath DS, Xiao H, Merril CR (1992) Tetranucleotide repeat polymorphism at the human beta-actin related pseudogene H-beta-Ac-psi-2 (ACTBP2). Nucleic Acids Res 20:1432
Wenda S, Dauber EM, Schwartz DWM, Jungbauer C, Weirich V, Wegener R, Mayr WR (2005) ACTBP2 (alias ACTBP8) is localized on chromosome 6 (band 6q14). Forensic Sci Int 148:207–209
Yu N, Kruskall MS, Yunis JJ, Knoll JHM, Uhl L, Alsoco S, Ohashi M, Clavijo O, Husain Z, Yunis EJ, Yunis JJ, Yunis EJ (2002) Disputed maternity leading to the identification of tetragametic chimerism. N Engl J Med 346:1545–1552
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wegener, R., Weirich, V., Dauber, E.M. et al. Mother–child exclusion due to paternal uniparental disomy 6. Int J Legal Med 120, 282–285 (2006). https://doi.org/10.1007/s00414-006-0077-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00414-006-0077-y