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Sudden unexpected death due to undiagnosed glioblastoma

Report of three cases and review of the literature

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Abstract

Although glioblastomas are among the most common primary cerebral neoplasms, sudden death due to these tumors is an uncommon event. Due to the usual rapid increase in intracranial pressure, patients develop symptoms rather early, leading to medical attention in time. A search for cases of sudden unexpected death due to undiagnosed glioblastoma from a total of 14,482 cases from the archives of the Institute of Legal Medicine in Hamburg in the period of 1991–2003 revealed only one such case. Out of a total of 5,432 cases from the Institute of Neuropathology, Hamburg, during the same period, two further cases were found. A comprehensive literature review on cases of sudden death due to primary cerebral neoplasms published so far revealed a total of 83 cases with only ten cases of glioblastoma (12%), whereas 55 of these cases were due to histological benign tumors (66%).

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Authors and Affiliations

  1. Institute of Neuropathology, University Medical Centre, Martinistrasse 52, 20246, Hamburg, Germany

    Jakob Matschke

  2. Institute of Legal Medicine, University Medical Centre, Martinistrasse 52, 20246, Hamburg, Germany

    Jakob Matschke & Michael Tsokos

Authors
  1. Jakob Matschke
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  2. Michael Tsokos
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Correspondence to Jakob Matschke.

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Matschke, J., Tsokos, M. Sudden unexpected death due to undiagnosed glioblastoma. Int J Legal Med 119, 280–284 (2005). https://doi.org/10.1007/s00414-005-0551-y

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  • DOI: https://doi.org/10.1007/s00414-005-0551-y

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