Abstract.
Telomeres are the stable ends of linear chromosomes in eukaryotes. These complex protein–nucleic acid structures are essential to maintain genomic stability and the integrity of linear chromosomes. We identified a new mutation in Drosophila that causes a high frequency of end-to-end fusions of chromosomes during mitosis and meiosis. Linear chromosomal ends appear to be essential for fusions to take place. These fusions do not resolve, leading to cycles of chromosomal breakage and rejoining and severe genome rearrangements. The gene is essential for normal cell proliferation and mutant tissue shows significant apoptosis. Our analysis suggests that the function encoded by the mutant gene is required to protect the linear ends of chromosomes.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
In revised form: 21 September 2000
Electronic Publication
Rights and permissions
About this article
Cite this article
Queiroz-Machado, J., Perdigão, J., Simões-Carvalho, P. et al. tef: a mutation that causes telomere fusion and severe genome rearrangements in Drosophila melanogaster . Chromosoma 110, 10–23 (2001). https://doi.org/10.1007/s004120000116
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s004120000116