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Starting and stopping SUMOylation

What regulates the regulator?

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Abstract

A large number of proteins are modified post-translationally by the ubiquitin-like protein (Ubl) SUMO. This process, known as sumoylation, regulates the function, localisation and activity of target proteins as part of normal cellular metabolism, e.g., during development, and through the cell cycle, as well as in response to a range of stresses. In order to be effective, the sumoylation pathway itself must also be regulated. This review describes how the SUMOylation process is regulated. In particular, regulation of the SUMO conjugation and deconjugation machinery at the level of transcription and by post-translational modifications is discussed.

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Acknowledgements

I thank Alan Lehmann, Keith Caldecott and Simon Morley for critical reading of the manuscript.

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  1. Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK

    Felicity Z. Watts

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  1. Felicity Z. Watts
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Correspondence to Felicity Z. Watts.

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Watts, F.Z. Starting and stopping SUMOylation. Chromosoma 122, 451–463 (2013). https://doi.org/10.1007/s00412-013-0422-0

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  • DOI: https://doi.org/10.1007/s00412-013-0422-0

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