Abstract
We report in this paper that the pentoxyresorufin-O-dealkylase (PROD) protein, encoded by the gene proliferation disrupter (prod), is associated with the telomeric chromatin in Drosophila melanogaster. It binds to a region just upstream of the promoter of the telomere-specific retrotransposon HeT-A, which is located in the long 3′untranslated region of the element near its oligo(A) tail. Reduction of PROD in prod heterozygote flies results in elevated levels of HeT-A RNA in the ovaries, suggesting that PROD functions as a repressor of HeT-A transcriptional activity at the telomeres.
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Acknowledgment
This work was supported by the Hungarian National Science Foundation OTKA no. T 037422 to Tibor Török and partially by the U.S. Public Health Service grant GM-56729 to H.B. C.B. was a participant in the AGEP Summer Research Program at UCI. We thank Jim Mason and Marika Walter for suggestions and critical reading of the manuscript.
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Török, T., Benitez, C., Takács, S. et al. The protein encoded by the gene proliferation disrupter (prod) is associated with the telomeric retrotransposon array in Drosophila melanogaster . Chromosoma 116, 185–195 (2007). https://doi.org/10.1007/s00412-006-0090-4
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DOI: https://doi.org/10.1007/s00412-006-0090-4