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Recent Advances in Bronchopulmonary Dysplasia: Pathophysiology, Prevention, and Treatment

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Abstract

Bronchopulmonary dysplasia (BPD) is potentially one of the most devastating conditions in premature infants with longstanding consequences involving multiple organ systems including adverse effects on pulmonary function and neurodevelopmental outcome. Here we review recent studies in the field to summarize the progress made in understanding in the pathophysiology, prognosis, prevention, and treatment of BPD in the last decade. The work reviewed includes the progress in understanding its pathobiology, genomic studies, ventilatory strategies, outcomes, and therapeutic interventions. We expect that this review will help guide clinicians to treat premature infants at risk for BPD better and lead researchers to initiate further studies in the field.

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Funding

Funding for the study was provided by NIH (HD51857, HL107118, HD071731, and HL127237) and TRDRP (17RT-0170 and 23RT-0018).

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  1. Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, David Geffen School of Medicine at UCLA, 1124 West Carson Street, Torrance, CA, 90502, USA

    Jung S. Hwang & Virender K. Rehan

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All applicable international, national, and/or institutional guidelines for the care and use of animals were followed for the animal studies performed by the authors. This chapter does not contain any studies with human participants performed by any of the authors.

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Hwang, J.S., Rehan, V.K. Recent Advances in Bronchopulmonary Dysplasia: Pathophysiology, Prevention, and Treatment. Lung 196, 129–138 (2018). https://doi.org/10.1007/s00408-018-0084-z

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