Abstract
The aim of this study was to evaluate the relationship between inappropriate overuse of inhaled corticosteroids and self-reported health status and the annual cost of patients with stable chronic obstructive pulmonary disease (COPD) recruited in the primary-care setting. An observational, crossover, descriptive study was conducted. Patients with stable COPD and aged ≥40 years, evaluated in primary care, were included. Data collected were demographic variables, clinical characteristics, self-reported health status (SF-12), the severity of the illness, treatment, and health-care resource utilization in the past year. The patients were recruited during a period of 3 months (from January 1 to March 31, 2003). Use was considered inappropriate when corticosteroids were prescribed by physicians for patients not meeting criteria for its use as recommended in guidelines. A total of 10,711 patients [75.6% males; mean age = 67.1 (SD = 9.66) years] were evaluated. Disease severity was mild in 35.5% of the cases, moderate in 53.4%, and severe in 11.2%. Among them, 3,697 (34.5%) subjects were prescribed inhaled corticosteroids or drug combinations containing such therapies, with a rate of inappropriate use of 18.2%. Physical health status was significantly lower among patients showing inappropriate corticosteroids use: 37.35 (SD = 9.53) vs. 40.7 (SD = 9.80) (p < 0.05). The annual cost per patient of COPD management was significantly higher in the group with inappropriate inhaled corticosteroids use: €1,590 (SD = 1,834) vs. €1,157 (SD = 1,536) (p < 0.05). Factors statistically associated with inappropriate use of corticosteroids were educational attainment [OR: 2.77 (95% CI: 1.36–5.63) for nonuniversity training], a history of heart disease [OR: 1.42 (95% CI: 1.02–1.97)], depression [OR: 1.47 (95% CI: 1.05–2.05)], any allergy [OR 1.69 (95% CI: 1.13–2.54)], and physical health status [OR 0.97 (95% CI: 0.96–0.98)]. Lack of adherence to the recommended criteria for using inhaled corticosteroids therapy in the management of COPD patients was associated with lower self-reported health status and higher costs. Factors statistically associated with inappropriate use of corticosteroids were educational attainment, a history of heart disease, depression, any allergy, and physical health status.
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Peces-Barba G, Barberà JA, Agustí A, Casanova C, Casas A, Izquierdo JL et al (2008) Diagnosis and management of chronic obstructive pulmonary disease: joint guidelines of the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) and the Latin American Thoracic Society (ALAT). Arch Bronconeumol 44:271–281 (in Spanish)
World Health Organization (2009) Chronic obstructive respiratory diseases. http://www.who.int/mediacentre/factsheets/fs315/en/index.html. Accessed 7 Jan 2009
Peña VS, Miravitlles M, Gabriel R, Jiménez-Ruiz CA, Villasante C, Masa JF, Viejo JL, Fernández-Fau L (2000) Geographic variations in prevalence and underdiagnosis of COPD. Results of the IBERPOC multicentre epidemiological study. Chest 118:981–989
Miravitlles M, Soriano JB, Garcia-Rio F, Muñoz L, Duran-Tauleria E, Sanchez G et al (2009) Prevalence of COPD in Spain: impact of undiagnosed COPD on quality of life and daily life activities. Thorax 64:863–868
Buist AS, McBurnie MA, Vollmer WM, Gillespie S, Burney P, Mannino DM et al (2007) International variation in the prevalence of COPD (The BOLD study): a population-based prevalence study. Lancet 370:741–750
Stahl E, Jansson SA, Jonsson AC, Svensson K, Lundbäck B, Andersson F (2003) Health-related quality of life, utility, and productivity outcomes instruments: ease of completion by subjects with COPD. Health Qual Life Outcomes 1:18
de Miguel-Díez J (2005) Health care costs of asthma and chronic obstructive pulmonary disease. Arch Bronconeumol 41:239–241 (in Spanish)
De Miguel Díez J, Izquierdo Alonso JL, Rodríguez González-Moro JM, De Lucas Ramos P, Molina París J (2003) Drug treatment of chronic obstructive pulmonary disease on two levels of patient care: degree of compliance with recommended protocols. Arch Bronconeumol 39:195–202 (in Spanish)
de Miguel-Diez J, Rodríguez JL, Calle M, Nieto MA, Alvarez-Sala JL (2002) Chronic obstructive pulmonary disease. Do you comply with the regulations? Med Integral 39:153–160 (in Spanish)
Miravitlles M, Brosa M, Velasco M, Crespo C, Gobartt E, Diaz S et al (2009) An economic analysis of pharmacological treatment of COPD in Spain. Respir Med 103:714–721
Global Initiative for Chronic Obstructive Lung Disease (2010) Global Strategy for diagnosis, management, and prevention of COPD. Updated 2010. http://www.goldcopd.org. Accessed 4 April 2011
Calverley PM, Anderson JA, Celli B, Ferguson GT, Jenkins C, Jones PW et al (2007) Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N Engl J Med 356:775–789
Singh S, Amin AV, Loke YK (2009) Long-term use of inhaled corticosteroids and the risk of pneumonia in chronic obstructive pulmonary disease: a meta-analysis. Arch Intern Med 169:219–229
Carrasco Garrido P, de Miguel Díez J, Rejas Gutiérrez J, Martín Centeno A, Gobartt Vázquez E, Gil de Miguel A et al (2006) Negative impact of chronic obstructive pulmonary disease on the health-related quality of life of patients. Results of the EPIDEPOC study. Health Qual Life Outcomes 4:31
Barberà JA, Peces-Barba G, Agustí AG, Izquierdo JL, Monsó E, Montemayor T, Viejo JL, Sociedad Española de Neumología y Cirugía Torácica (SEPAR) (2001) Clinical guidelines for the diagnosis and treatment of chronic obstructive pulmonary disease. Arch Bronconeumol 37:297–316 (in Spanish)
Anthonisen NR, Manfreda J, Warren CP, Hershfield ES, Harding GK, Nelson NA (1987) Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med 106:196–204
Ware JE, Kosinski M, Keller SD (1996) A 12-item short-form health survey. Construction of scales and preliminary tests of reliability and validity. Med Care 34:220–233
Vilagut G, Ferrer M, Rajmil L, Rebollo P, Permanyer-Miralda G, Quintana JM et al (2005) The Spanish version of the Short Form 36 Health Survey: a decade of experience and new developments. Gac Sanit 19:135–150 (in Spanish)
Spanish National Statistics Institute. Results of 1999. http://www.ine.es. Accessed December 2003
de Miguel Díez J, Calle Rubio M, Rodríguez Hermosa JL, Álvarez-Sala JL (2007) Guidelines for the treatment of COPD. Hot Topics Respir Med 5:7–14
Ramsey SD (2000) Suboptimal medical therapy in COPD. Exploring the causes and consequences. Chest 117:33S–37S
Decramer M, Bartsch P, Pauwels R, Yernault JC (2003) Management of COPD according to guidelines. A national survey among Belgian physicians. Monaldi Arch Chest Dis 59:62–80
Roede BM, Bindels PJ, Brouwer HJ, Bresser P, de Borgie CA, Prins JM (2006) Antibiotics and steroids for exacerbations of COPD in primary care: compliance with Dutch guidelines. Br J Gen Pract 56:662–665
Glaab T, Banik NRO, Wencker M (2006) National survey of guideline-compliant COPD management among pneumologists and primary care physicians. COPD 3:141–148
Ruse CE, Molyneux AW (2005) A study of the management of COPD according to established guidelines and the implications for older patients. Age Ageing 34:299–301
Rutschmann OT, Janssens JP, Vermeulen B, Sarasin FP (2004) Knowledge of guidelines for the management of COPD: a survey of primary care physicians. Respir Med 98:932–937
Tsagaraki V, Markantonis SL, Amfilochiou A (2007) Pharmacotherapeutic management of COPD patients in Greece—adherence to international guidelines. J Clin Pharm Ther 31:369–374
de Miguel Díez J, Izquierdo Alonso JL, Molina París J, Bellón Cano JM, Rodríguez González-Moro JM, de Lucas Ramos P (2005) [Factors affecting drug prescription in patients with stable COPD: results from a multicenter Spanish study (IDENTEPOC). Arch Bronconeumol 41:63–70 (in Spanish)
Miravitlles M, De la Roza C, Naberan K, Lamban M, Gobartt E, Martín A (2007) Use of spirometry and patterns of prescribing in COPD in primary care. Respir Med 101:1753–1760
Corden ZM, Bosley CM, Rees PJ, Cochrane GM (1997) Home nebulized therapy for patients with COPD: patients’ compliance with treatment and its relation to quality of life. Chest 112:1278–1282
Izquierdo Alonso JL, De Miguel Díez J (2004) Economic impact of pulmonary drugs on direct costs of stable chronic obstructive pulmonary disease. COPD 1:215–223
Marco JL, Martin Berra JC, Corres IM, Luque DR, Zubillaga GG (1998) Chronic obstructive lung disease in the general population. An epidemiologic study performed in Guipuzcoa. Arch Bronconeumol 34:23–27 (in Spanish)
Brotons B, Perez JA, Sanchez-Toril F, Soriano S, Hernandez J, Belenguer JL (1994) The prevalence of chronic obstructive pulmonary disease and asthma. A cross-sectional study. Arch Bronconeumol 30:149–152 (in Spanish)
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de Miguel-Díez, J., Carrasco-Garrido, P., Rejas-Gutierrez, J. et al. Inappropriate Overuse of Inhaled Corticosteroids for COPD Patients: Impact on Health Costs and Health Status. Lung 189, 199–206 (2011). https://doi.org/10.1007/s00408-011-9289-0
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DOI: https://doi.org/10.1007/s00408-011-9289-0