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Soluble Intercellular Adhesion Molecule-1 and E-selectin in Patients with Asthma Exacerbation

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Abstract

Soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin) are important factors in immunological processes of inflammatory cell buildup in target tissues. Studies have suggested that these molecules could be important markers of inflammatory diseases. This study was undertaken to assess the levels of sICAM-1 and sE-selectin during an acute attack of asthma in adults and children and to establish normal values (95th percentile) in healthy control subjects. We analyzed serum levels of ICAM-1 and E-selectin in 120 children and adults obtained during an acute attack of asthma: 40 with severe and 80 with moderately severe attack, and 50 healthy subjects as controls by ELISA (enzyme linked immunosorbent assay). sICAM-1 from patients with asthma was significantly higher than healthy controls (P < 0.001) but not for sE-selectin (P = 0.778). Significant differences were observed in moderately severe attack versus controls and severe attack of asthma for sICAM-1. With 95th percentile levels as cutoff for normal values (sICAM-1 = 585.08 ng/ml, sE-selectin = 160.87 ng/ml), it was observed that 88.3% of subjects (sICAM-1) and 98.5% of subjects (sE-selectin) with an acute attack of asthma had levels within the normal range. Although mean serum levels of sICAM-1 are higher in asthmatics than normal controls, it may be necessary to establish individual baseline values for serial estimation to evaluate their clinical relevance.

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References

  1. GINA executive committee (2007) Global Strategy for Asthma Management and Prevention 2007. In: Global initiative for asthma. McMaster University, Canada, pp 16–96

  2. Tang RB, Chen SJ, Soong WJ, Chung RL (2002) Circulating adhesion molecules in sera of asthmatic children. Pediatr Pulmonol 33:249–254

    Article  PubMed  Google Scholar 

  3. Shi HZ, Chen YQ, Qin SM (1999) Inhaled IL-5 increases concentrations of soluble intracellular adhesion molecule-1 in sputum from atopic asthmatic subjects. J Allergy Clin Immunol 103:463–467

    Article  PubMed  CAS  Google Scholar 

  4. Yamashita N, Kaneko S, Kouro O, Furue M, Yamamoto S, Sakane T (1997) Soluble E-selectin as a marker of disease activity in atopic dermatitis. J Allergy Clin Immunol 99:410–414

    Article  PubMed  CAS  Google Scholar 

  5. Stelmach I, Jerzynska J, Kuna P (2002) A randomized, double-hyperresponsiveness and serum eosinophilic cationic protein (ECP), soluble interleukin 2 receptor (sIL-2R), IL-4, and soluble intercellular adhesion molecule 1 (sICAM-1) in children with asthma. J Allergy Clin Immunol 109:257–263

    Article  PubMed  CAS  Google Scholar 

  6. Bloemen PGM, Henrichs PAJ, Nijkamp FP (1997) Cell adhesion molecules and asthma. Clin Exp Allergy 27:128–141

    Article  PubMed  CAS  Google Scholar 

  7. Tsegaya A, Messele T, Tilahun T, Hailu E, Sahlu T, Doorly R, Fontanet AL, Rinked de Wit TF (1999) Immunohematological reference ranges for adult Ethiopians. Clin Diagn Lab Immunol 6:410–414

    Google Scholar 

  8. Currie GP, Fardon TC, Lee DKC (2005) The role of measuring airway hyperresponsiveness and inflammatory biomarkers in asthma. Ther Clin Risk Manag 1:83–92

    Article  PubMed  CAS  Google Scholar 

  9. Marguet C, Dean TP, Warner JO (2000) Soluble intercellular adhesion molecule-1 (sICAM-1) and interferon-gamma in bronchoalveolar lavage fluid from children with airway diseases. Am J Respir Crit Care Med 162:1016–1022

    PubMed  CAS  Google Scholar 

  10. El-Sawy IH, Badr-El-Din O, El-Azzouni OE, Motawae HA (1999) Soluble intracellular adhesion molecule-1 in sera of children with bronchial asthma exacerbation. Int Arch Allergy Immunol 119:126–132

    Article  PubMed  CAS  Google Scholar 

  11. Hashimoto S, Imai K, Kobayashi T, Amemiya E, Takahashi Y, Tomita Y, Iwatal T, Suguro H, Yamaguchi M, Yachi A, Horie T (2007) Elevated levels of soluble ICAM-1 in sera from patients with bronchial asthma. Allergy 48:370–372

    Article  Google Scholar 

  12. Shiota Y, Wilson JG, Marukawa M, Ono T, Kaji M (1996) Soluble intercellular adhesion molecule 1 (ICAM-1) antigen in sera of bronchial asthmatics. Chest 109:94–99

    Article  PubMed  CAS  Google Scholar 

  13. Reha C, Emin D, Necla T, Fatmanur C (2000) Circulating ICAM-1 levels in bronchial asthma and the effect of inhaled corticosteroids. Ann Allergy Asthma Immunol 84:539–541

    Article  Google Scholar 

  14. Ceyhan BB, Sungur M, Celikel T, Ozgün SS (1995) Role of the adhesion molecule ICAM-1 in asthma. J Asthma 32:419–427

    Article  PubMed  CAS  Google Scholar 

  15. Laan MP, Koning H, Baert MR, Oranje AP, Buurman WA, Savelkoul HF, Neijens HJ (1998) Levels of soluble intercellular adhesion molecule-1, soluble E-selectin, tumor necrosis factor-alpha, and soluble tumor necrosis factor receptor p55 and p75 in atopic children. Allergy 53:51–58

    Article  PubMed  CAS  Google Scholar 

  16. Riise GC, Larsson S, Lowhagen O, Andersson BA (2007) Circulating leukocyte adhesion molecules in stable asthma and nonobstructive chronic bronchitis. Allergy 50:693–698

    Article  Google Scholar 

  17. Hamzaoui A, Ammar J, El Mekki F, Borgi O, Ghrairi H, Brahim MB, Hamzaoui K (2001) Elevation of serum soluble E-selectin and VCAM-1 in severe asthma. Mediators Inflamm 10:339–342

    Article  PubMed  CAS  Google Scholar 

  18. Montefort S, Lai CKW, Leung J, Lai KN, Chan HS, Haskard DO, Howarth PH, Holgate ST (1994) Circulating adhesion molecules in asthma. Am J Respir Crit Care Med 149:1149–1152

    PubMed  CAS  Google Scholar 

  19. Nadi E, Hajilooi M, Zeraati F, Ansari M, Tavana S, Hashemi SH, Rafiei A (2007) E-selectin S128R polymorphism leads to severe asthma. Iran J Allergy Asthma Immunol 6:49–57

    PubMed  CAS  Google Scholar 

  20. Oymar K, Bjerknes R (2007) Different patterns of circulating adhesion molecules in children with bronchial asthma and acute bronchiolitis. Pediatr Allergy Immunol 9:73–79

    Article  Google Scholar 

  21. Doğu F, Ikincioğullari A, Eğin Y, Babacan E (2002) Circulating adhesion molecule levels in childhood asthma. Indian Pediatr 39:1017–1021

    PubMed  Google Scholar 

  22. Gorska-Ciebiada M (2006) ICAM-1 and TNF-α in patients with persistent asthma-relationship with disease severity. J Allergy Clin Immunol 117(2, Suppl 1):258

    Article  Google Scholar 

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Acknowledgment

The authors thank doctors, patients, and patients’ families in Cheluvamba and JSS hospitals and Allergy, Asthma and Chest Center of Mysore; the Principal, Mysore Medical College & Research Institute; Dr. Rajendra Kumar, Cheluvamba Hospital, Mysore Medical College & Research Institute, Dr. S. K. Chaya and Dr. A. K. Prabhakar, JSS Hospital, Mysore, M. Kareem Khan, Swamy Kumar, and Mrs. Sumithra for their help. Mahdi Bijanzadeh is grateful to the University of Mysore, Prof. S. R. Ramesh, Chairman, DOS in Zoology for checking the English in the manuscript and Ahwaz University of Medical Sciences, Iran, for providing facilities to perform this work.

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Authors and Affiliations

  1. Human Genetics Laboratory, Department of Studies in Zoology, University of Mysore, Manasagangothri, Mysore, 570 006, Karnataka, India

    Mahdi Bijanzadeh & Nallur B. Ramachandra

  2. J.S.S. Medical College, J.S.S. Hospital, Mysore, India

    P. A. Mahesh, G. S. Vijayakumar & B. S. Jayaraj

  3. Department of Pediatrics, Cheluvamba Hospital, Mysore Medical College and Research Institute, Mysore, India

    Mysore R. Savitha & Pradeep Kumar

  4. Blood Bank, Department of Pathology, K.R. Hospital Mysore Medical College and Research Institute, Mysore, India

    B. S. Manjunath

Authors
  1. Mahdi Bijanzadeh
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  2. Nallur B. Ramachandra
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  3. P. A. Mahesh
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  4. Mysore R. Savitha
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  5. G. S. Vijayakumar
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  6. Pradeep Kumar
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  7. B. S. Manjunath
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  8. B. S. Jayaraj
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Correspondence to Nallur B. Ramachandra.

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Bijanzadeh, M., Ramachandra, N.B., Mahesh, P.A. et al. Soluble Intercellular Adhesion Molecule-1 and E-selectin in Patients with Asthma Exacerbation. Lung 187, 315–320 (2009). https://doi.org/10.1007/s00408-009-9171-5

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  • DOI: https://doi.org/10.1007/s00408-009-9171-5

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