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Comparing the Relationship of Taxol-Based Chemotherapy Response with P-glycoprotein and Lung Resistance-Related Protein Expression in Non-Small Cell Lung Cancer

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Abstract

Our aim was to compare Taxol-based chemotherapy response of non-small cell lung cancer (NSCLC) with P-glycoprotein (Pgp) or lung resistance protein expression (LRP). Immunohistochemical analyses were performed on multiple nonconsecutive sections of the biopsy specimens to detect Pgp and LPR expressions in 40 patients with advanced NSCLC before Taxol-based chemotherapy. The chemotherapy response was evaluated by clinical and radiological methods in the third month after completion of treatment. No significant differences of prognostic factors (age, sex, body weight loss, performance status, tumor size, tumor stage, and tumor cell type) were found between the 20 patients with good and the 20 patients with poor responses. The incidence difference of positive Pgp expressions between good and poor responses was significant, however, the difference of LRP expression was not. We concluded that Taxol-based chemotherapy response of patients with NSCLC was related to Pgp but not LPR expression.

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Authors and Affiliations

  1. Cancer Center and Department of Radiation Oncology, Taipei Medical University Hospital, Taipei, Taiwan

    J. -F. Chiou

  2. Department of Radiation Therapy and Oncology, China Medical University Hospital, Taichung, Taiwan

    J. -A. Liang

  3. Division of Pulmonary/Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan

    W. -H. Hsu

  4. Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan

    J. -J. Wang

  5. Department of Anesthesiology, Tri-Service General Hospital, Taipei, Taiwan

    S. -T. Ho

  6. Department of Medical Research, China Medical University Hospital, No. 2, Yuh-Der Road, Taichung 404, Taiwan

    A. Kao

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  1. J. -F. Chiou
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  2. J. -A. Liang
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  3. W. -H. Hsu
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  4. J. -J. Wang
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  5. S. -T. Ho
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  6. A. Kao
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Correspondence to A. Kao.

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Chiou, JF., Liang, JA., Hsu, WH. et al. Comparing the Relationship of Taxol-Based Chemotherapy Response with P-glycoprotein and Lung Resistance-Related Protein Expression in Non-Small Cell Lung Cancer . Lung 181, 267–273 (2003). https://doi.org/10.1007/s00408-003-1029-7

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  • DOI: https://doi.org/10.1007/s00408-003-1029-7

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