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Deficits in social cognition: a marker for psychiatric disorders?

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Abstract

Research on social cognition focuses on several human abilities with a huge diversity in the approaches to tap the different functions. Empathy, for instance, is a rather elaborated human ability, and several recent studies point to significant impairments in patients suffering from psychiatric disorders, such as schizophrenia or autism. Neuroimaging data from these patients commonly indicate neural dysfunctions accompanying the behavioral deficits. Studying the neural correlates of social cognition is of particular importance, because deficits in these domains may explain the major dysfunctions in psychiatric disorders that prevent effective (re) integration into work and social life. It has also become clearer that social cognition deficits, similar to emotion dysfunctions, may represent trait markers and endophenotypes of the diseases. However, there are several challenges for future studies on social cognitive dysfunctions: on the one hand, the complexity of the constructs and thus the variety of definitions which make it hard to develop adequate tasks. On the other hand, results are needed that particularly address the disorder specificity of these impairments, as well as their potential as endophenotypes via analyzing people at high-risk and their relatives.

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References

  1. Brunet-Gouet E, Decety J (2006) Social brain dysfunctions in schizophrenia: a review of neuroimaging studies. Psychiatry Res 148:75–92

    Article  PubMed  Google Scholar 

  2. Couture SM, Penn DL, Roberts DL (2006) The functional significance of social cognition in schizophrenia: a review. Schizophr Bull 31:S44–S63

    Article  Google Scholar 

  3. Green MF, Olivier B, Crawley JN et al (2005) Social cognition in schizophrenia: recommendations from the measurement and treatment research to improve cognition in schizophrenia new approaches conference. Schizophr Bull 31:882–887

    Article  PubMed  Google Scholar 

  4. Bless H, Fiedler K, Strack F (2003) Social cognition: how individuals construct social reality. Taylor & Francis, London

    Google Scholar 

  5. Lee KH, Farrow TFD, Spence SA et al (2004) Social cognition, brain networks and schizophrenia. Psychol Med 34:391–400

    Article  PubMed  CAS  Google Scholar 

  6. Pinkham AE, Hopfinger JB, Pelphrey KA et al (2008) Neural bases for impaired social cognition in schizophrenia and autism spectrum disorders. Schizophr Res 99:164–175

    Article  PubMed  Google Scholar 

  7. Shur S, Shamay-Tsoory SG, Levkovitz Y (2008) Integration of emotional and cognitive aspects of theory of mind in schizophrenia and its relation to prefrontal neurocognitive performance. Cogn Neuropsychiatry 13:472–490

    Article  PubMed  Google Scholar 

  8. Ochsner KN (2008) The social-emotional processing stream: five core constructs and their translational potential for schizophrenia and beyond. Biol Psychiatry 64:48–61

    Article  PubMed  Google Scholar 

  9. Gallese V (2003) The roots of empathy: the shared manifold hypothesis and the neural basis of intersubjectivity. Psychopathology 36:171–180

    Article  PubMed  Google Scholar 

  10. Kilner JM, Friston KJ, Frith CD (2007) Predictive coding: an account of the mirror neuron system. Cogn Process 8:159–166

    Article  PubMed  Google Scholar 

  11. Brüne M (2005) “Theory of mind” in schizophrenia: a review of the literature. Schizophr Bull 31:21–42

    Article  PubMed  Google Scholar 

  12. Habel U, Chechko N, Pauly K et al (2010) Neural correlates of emotion recognition in schizophrenia. Schizophr Res 122:113–123

    Article  PubMed  Google Scholar 

  13. Schneider F, Gur RC, Koch K et al (2006) Impairment in the specificity of emotion processing in schizophrenia. Am J Psychiatry 163:442–447

    Article  PubMed  Google Scholar 

  14. Van’t Wout M, van Dijke A, Aleman A et al (2007) Fearful faces in schizophrenia: the relationship between patient characteristics and facial affect recognition. J Nerv Ment Dis 195:758–764

    Article  PubMed  Google Scholar 

  15. Shamay-Tsoory SG, Aharon-Peretz J, Levkovitz Y (2007) The neuroanatomical basis of affective mentalizing in schizophrenia: comparison of patients with schizophrenia and patients with localized prefrontal lesions. Schizophr Res 90:274–283

    Article  PubMed  Google Scholar 

  16. Shamay-Tsoory SG, Shur S, Harari H et al (2007) Neurocognitive basis of impaired empathy in schizophrenia. Neuropsychology 21:431–438

    Article  PubMed  Google Scholar 

  17. Langdon R, Ward P (2009) Taking the perspective of the other contributes to awareness of illness in schizophrenia. Schizophr Bull 35:1003–1011

    Article  PubMed  Google Scholar 

  18. Moore R, Blackwood N, Corcoran R et al (2006) Misunderstanding the intentions of others: an exploratory study of the cognitive etiology of persecutory delusions in very late-onset schizophrenia-like psychosis. Am J Geriatr Psychiatry 14:410–418

    Article  PubMed  Google Scholar 

  19. Decety J, Jackson PL (2004) The functional architecture of human empathy. Behav Cogn Neurosci Rev 3:71–100

    Article  PubMed  Google Scholar 

  20. Derntl B, Finkelmeyer A, Toygar TK et al (2009) Generalized deficit in all core components of empathy in schizophrenia. Schizophr Res 108:197–206

    Article  PubMed  Google Scholar 

  21. Fakra E, Salgado-Pineda P, Delaveau P et al (2008) Neural bases of different cognitive strategies for facial affect processing in schizophrenia. Schizophr Res 100:191–205

    Article  PubMed  Google Scholar 

  22. Gur RE, Loughead J, Kohler CG et al (2007) Limbic activation associated with misidentification of fearful faces and flat affect in schizophrenia. Arch Gen Psychiatry 64:1356–1366

    Article  PubMed  Google Scholar 

  23. Seiferth NY, Pauly K, Habel U et al (2008) Increased neural response related to neutral faces in individuals at risk for psychosis. Neuroimage 40:289–297

    Article  PubMed  Google Scholar 

  24. Seiferth NY, Pauly K, Kellermann T et al (2009) Neuronal correlates of facial emotion discrimination in early onset schizophrenia. Neuropsychopharmacology 34:477–487

    Article  PubMed  Google Scholar 

  25. Holt DJ, Kunkel L, Weiss AP et al (2006) Increased medial temporal lobe activation during the passive viewing of emotional and neutral facial expressions in schizophrenia. Schizophr Res 82:153–162

    Article  PubMed  Google Scholar 

  26. Mier D, Sauer C, Lis S et al (2010) Neuronal correlates of affective theory of mind in schizophrenia out-patients: evidence for a baseline deficit. Psychol Med 40:1607–1617

    Article  PubMed  CAS  Google Scholar 

  27. Brunet E, Sarfati Y, Hardy-Baylé M-C et al (2003) Abnormalities of brain function during a nonverbal theory of mind task in schizophrenia. Neuropsychologia 41:1574–1582

    Article  PubMed  Google Scholar 

  28. Lee KH, Brown WH, Egleston PN et al (2006) A functional magnetic resonance imaging study of social cognition in schizophrenia during an acute episode and after recovery. Am J Psychiatry 163:1926–1933

    Article  PubMed  Google Scholar 

  29. Russell TA, Rubia K, Bullmore ET et al (2000) Exploring the social brain in schizophrenia: left prefrontal underactivation during mental state attribution. Am J Psychiatry 157:2040–2042

    Article  PubMed  CAS  Google Scholar 

  30. Benedetti F, Bernasconi A, Bosia M et al (2009) Functional and structural brain correlates of theory of mind and empathy deficits in schizophrenia. Schizophr Res 114:154–160

    Article  PubMed  Google Scholar 

  31. Lee SJ, Kang DH, Kim C-W et al (2010) Multi-level comparison of empathy in schizophrenia: an fMRI study of a cartoon task. Psychiatry Res 181:121–129

    Article  PubMed  Google Scholar 

  32. Couture SM, Penn DL, Losh M et al (2010) Comparison of social cognitive functioning in schizophrenia and high functioning autism: more convergence than divergence. Psychol Med 40:569–579

    Article  PubMed  Google Scholar 

  33. Iacoboni M, Dapretto M (2006) The mirror neuron system and the consequences of its dysfunction. Nat Rev Neurosci 7:942–951

    Article  PubMed  CAS  Google Scholar 

  34. Williams JH, Whiten A, Suddendorf T et al (2001) Imitation, mirror neurons and autism. Neurosci Biobehav Rev 25:287–295

    Article  PubMed  CAS  Google Scholar 

  35. Williams JHG (2008) Self-other relations in social development and autism: multiple roles for mirror neurons and other brain bases. Autism Res 1:73–90

    Article  PubMed  Google Scholar 

  36. Gallese V, Rochat M, Cossu G et al (2009) Motor cognition and its role in the phylogeny and ontogeny of action understanding. Dev Psychol 45:103–113

    Article  PubMed  Google Scholar 

  37. Dapretto M, Davies MS, Pfeifer JH et al (2006) Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders. Nat Neurosci 9:28–30

    Article  PubMed  CAS  Google Scholar 

  38. Schultz RT (2005) Developmental deficits in social perception in autism: the role of the amygdala and fusiform face area. Int J Dev Neurosci 23:125–141

    Article  PubMed  Google Scholar 

  39. Critchley HD, Daly EM, Bullmore ET et al (2000) The functional neuroanatomy of social behaviour: changes in cerebral blood flow when people with autistic disorder process facial expressions. Brain 123:2203–2212

    Article  PubMed  Google Scholar 

  40. Hadjikhani N, Joseph RM, Snyder J et al (2007) Abnormal activation of the social brain during face perception in autism. Hum Brain Mapp 28:441–449

    Article  PubMed  Google Scholar 

  41. Hobson RP, Bishop M (2003) The pathogenesis of autism: insights from congenital blindness. Phil Trans R Soc Lond B Biol Sci 358:335–344

    Article  Google Scholar 

  42. Pierce K, Redcay E (2008) Fusiform function in children with an autism spectrum disorder is a matter of “who”. Biol Psychiatry 64:552–560

    Article  PubMed  Google Scholar 

  43. Dziobek I, Bahnemann M, Convit A et al (2010) The role of the fusiform-amygdala system in the pathophysiology of autism. Arch Gen Psychiatry 67:397–405

    Article  PubMed  Google Scholar 

  44. Castelli F, Frith C, Happé F et al (2002) Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes. Brain 125:1839–1849

    Article  PubMed  Google Scholar 

  45. Pelphrey K, Adolphs R, Morris JP (2004) Neuroanatomical substrates of social cognition dysfunction in autism. Ment Retard Dev Disabil Res Rev 10:259–271

    Article  PubMed  Google Scholar 

  46. Wang AT, Lee SS, Sigman M et al (2006) Neural basis of irony comprehension in children with autism: the role of prosody and context. Brain 129:932–943

    Article  PubMed  Google Scholar 

  47. Wang AT, Lee SS, Sigman M et al (2007) Reading affect in the face and voice: neural correlates of interpreting communicative intent in children and adolescents with autism spectrum disorders. Arch Gen Psychiatry 64:698–708

    Article  PubMed  Google Scholar 

  48. Bird G, Silani G, Brindley R et al (2010) Empathic brain responses in insula are modulated by levels of alexithymia but not autism. Brain 133:1515–1525

    Article  PubMed  Google Scholar 

  49. Sergi MJ, Rassovsky Y, Widmark C et al (2007) Social cognition in schizophrenia: relationships with neurocognition and negative symptoms. Schizophr Res 90:316–324

    Article  PubMed  Google Scholar 

  50. Habel U, Koch K, Kellermann T et al (2010) Training of affect recognition in schizophrenia: neurobiological correlates. Soc Neurosci 5:92–104

    Article  PubMed  Google Scholar 

  51. Horan WP, Kern RS, Tripp C et al (2011) Efficacy and specificity of social cognitive skills training for outpatients with psychotic disorders. J Psychiatr Res doi:10.1016/j.jpsychires.2011.01.015

  52. Brekke JS, Hoe M, Long J et al (2007) How neurocognition and social cognition influence functional change during community-based psychosocial rehabilitation for individuals with schizophrenia. Schizophr Bull 33:1247–1256

    Article  PubMed  Google Scholar 

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Acknowledgments

B. Derntl and U. Habel were supported by the German Research Foundation (DFG IRTG 1328; Ha3202/7-1, KFO 112) and the Austrian Science Fund (FWF P23533).

Conflict of interest

The authors declare that they have no conflict of interest.

This supplement was not sponsored by outside commercial interests. It was funded by the German Association for Psychiatry and Psychotherapy (DGPPN).

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Correspondence to Birgit Derntl.

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Derntl, B., Habel, U. Deficits in social cognition: a marker for psychiatric disorders?. Eur Arch Psychiatry Clin Neurosci 261 (Suppl 2), 145 (2011). https://doi.org/10.1007/s00406-011-0244-0

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