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Cerebrospinal fluid diagnostics in first-episode schizophrenia

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European Archives of Psychiatry and Clinical Neuroscience Aims and scope Submit manuscript

Abstract

We evaluated the clinical use and the safety of cerebrospinal fluid diagnostics in 155 patients with the suspected diagnosis of first-episode schizophrenia. Five patients (3.2%) revealed pathological findings that lead to diagnostic re-evaluation and changes in clinical management. No serious adverse events occurred, but we documented 16 (10.3%) cases of mild to moderate headache or local pain at the puncture site. Our results underline the value of lumbar puncture in the clinical workup of first-episode patients with suspected schizophrenia.

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Acknowledgments

This study was supported by the Stanley Medical Research Institute (01–315 + 03-NV-003, FML). We gratefully acknowledge the contributions of Dres. C. W. Gerth, B. M. Nolden, D. Schreiber, C. Mauss, T. Buzello, and M. A. Neatby to the collection of data in this study. Our special thanks go to all patients participating in this study.

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Authors and Affiliations

  1. Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Ruprecht-Karls-University Heidelberg, J5, 68159, Mannheim, Germany

    Laura Kranaster, Dagmar Koethe, Carolin Hoyer, Andreas Meyer-Lindenberg & F. Markus Leweke

  2. Department of Psychiatry and Psychotherapy, University of Cologne, 50924, Cologne, Germany

    Laura Kranaster, Dagmar Koethe, Carolin Hoyer & F. Markus Leweke

Authors
  1. Laura Kranaster
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  2. Dagmar Koethe
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  3. Carolin Hoyer
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  4. Andreas Meyer-Lindenberg
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  5. F. Markus Leweke
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Corresponding author

Correspondence to F. Markus Leweke.

Additional information

L. Kranaster, D. Koethe authors contributed equally to the study.

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Kranaster, L., Koethe, D., Hoyer, C. et al. Cerebrospinal fluid diagnostics in first-episode schizophrenia. Eur Arch Psychiatry Clin Neurosci 261, 529–530 (2011). https://doi.org/10.1007/s00406-011-0193-7

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  • DOI: https://doi.org/10.1007/s00406-011-0193-7

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