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Effects of atypical (risperidone) and typical (haloperidol) antipsychotic agents on astroglial functions

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Abstract

Although classical and atypical antipsychotics may have different neurotoxic effects, their underlying mechanisms remain to be elucidated, especially regarding neuroglial function. In the present study, we compared the atypical antipsychotic risperidone (0.01–10 μM) with the typical antipsychotic haloperidol (0.01–10 μM) regarding different aspects such as glutamate uptake, glutamine synthetase (GS) activity, glutathione (GSH) content, and intracellular reactive oxygen species (ROS) production in C6 astroglial cells. Risperidone significantly increased glutamate uptake (up to 27%), GS activity (14%), and GSH content (up to 17%). In contrast, haloperidol was not able to change any of these glial functions. However, at concentration of 10 μM, haloperidol increased (12%) ROS production. Our data contribute to the clarification of different hypothesis concerning the putative neural responses after stimulus with different antipsychotics, and may establish important insights about how brain rewiring could be enhanced.

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Acknowledgments

We are grateful to Fares Zeidán Chuliá for critical reading, helpful discussions and corrections of the manuscript. This work was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), FINEP/Rede IBN 01.06.0842-00 and INCT-EN National Institute of Science and Technology for Excitotoxicity and Neuroprotection.

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Authors and Affiliations

  1. Neuroglial Plasticity Laboratory, Postgraduate Programme of Biochemistry, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2600 Anexo-Bairro Santa Cecilia, Porto Alegre, RS, 90035-003, Brazil

    André Quincozes-Santos, Larissa Daniele Bobermin, Rafaela Pestana Leques Tonial, Victorio Bambini-Junior & Carmem Gottfried

  2. Pervasive Developmental Disorders Program (ProTID), Pediatric Neurology Center at Porto Alegre Clinical Hospital, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil

    Rudimar Riesgo & Carmem Gottfried

Authors
  1. André Quincozes-Santos
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  2. Larissa Daniele Bobermin
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  3. Rafaela Pestana Leques Tonial
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  4. Victorio Bambini-Junior
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  5. Rudimar Riesgo
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  6. Carmem Gottfried
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Correspondence to Carmem Gottfried.

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Quincozes-Santos, A., Bobermin, L.D., Tonial, R.P.L. et al. Effects of atypical (risperidone) and typical (haloperidol) antipsychotic agents on astroglial functions. Eur Arch Psychiatry Clin Neurosci 260, 475–481 (2010). https://doi.org/10.1007/s00406-009-0095-0

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  • DOI: https://doi.org/10.1007/s00406-009-0095-0

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