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Suicide, stress and serotonin receptor 1A promoter polymorphism -1019C>G in Slovenian suicide victims

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Abstract

Implication of serotonergic system in suicide and suicide attempts has been discussed for several years. One of the most abundant serotonin receptors in the mammalian brain is the receptor 1A (5-HT1A); studies of its polymorphisms and suicide have provided very inconsistent results so far. The suggestion that the G allele depresses HTR1A autoreceptor expression, and therefore reduces serotonergic neurotransmission that might predispose to depression and suicide, made the promoter polymorphism -1019C>G a very promising candidate gene. In our study we analyzed promoter polymorphism -1019C>G on 323 suicide victims and 190 controls (all of Slovenian origin), taking into account sex, suicide method, and in case of suicide victims also stressful life events. Differences in the distributions of genotype and allele frequencies were not statistically significant between suicide victims and control group, and the same was found for distributions according to sex and suicide method. For 62 suicide victims information about stressful life events in the month prior to the suicide and in childhood was provided. For analysis we combined CG/GG genotypes and compared them to the CC genotype. More stressful life events in the month prior to the suicide were reported for the subgroup with CC genotype (mean number of events = 2.53; SD = 1.50) in comparison to subgroup with CG/GG genotypes (mean number of events = 1.58; SD = 1.32; P < 0.05). However, subgroups of suicide victims with CC or CG/GG genotypes did not differ regarding numbers of reported stressful life events in childhood (P > 0.05). Our study provides no evidence for the implication of HTR1A promoter polymorphism in suicide in general, but it suggests further studies that would take into account the interconnected network of suicide completion, genetic background and stress, beside other risk factors.

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References

  1. Albert PR, Lemonde S (2004) 5-HT1A receptors, gene repression, and depression: guilt by association. Neuroscientist 10:575–593

    Article  PubMed  CAS  Google Scholar 

  2. Anttila S, Huuhka K, Huuhka M, Rontu R, Hurme M, Leinonen E, Lehtimaki T (2007) Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression. J Neural Transm 114:1065–1068

    Article  PubMed  CAS  Google Scholar 

  3. Arango V, Underwood MD, Boldrini M, Tamir H, Kassir SA, Hsiung S, Chen JJ, Mann JJ (2001) Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. Neuropsychopharmacology 25:892–903

    Article  PubMed  CAS  Google Scholar 

  4. Arango V, Underwood MD, Gubbi AV, Mann JJ (1995) Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Res 688:121–133

    Article  PubMed  CAS  Google Scholar 

  5. Asberg M, Thoren P, Traskman L, Bertilsson L, Ringberger V (1976) “Serotonin depression”—a biochemical subgroup within the affective disorders? Science 191:478–480

    Article  PubMed  CAS  Google Scholar 

  6. Asberg M, Traskman L, Thoren P (1976) 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Arch Gen Psychiatry 33:1193–1197

    PubMed  CAS  Google Scholar 

  7. Baud P (2005) Personality traits as intermediary phenotypes in suicidal behavior: genetic issues. Am J Med Genet C Semin Med Genet 133:34–42

    Google Scholar 

  8. Bondy B, Buettner A, Zill P (2006) Genetics of suicide. Mol Psychiatry 11:336–351

    Article  PubMed  CAS  Google Scholar 

  9. Brugha T, Bebbington P, Tennant C, Hurry J (1985) The list of threatening experiences: a subset of 12 life event categories with considerable long-term contextual threat. Psychol Med 15:189–194

    Article  PubMed  CAS  Google Scholar 

  10. Chaouloff F, Berton O, Mormede P (1999) Serotonin and stress. Neuropsychopharmacology 21:28S–32S

    PubMed  CAS  Google Scholar 

  11. Hong CJ, Chen TJ, Yu YW, Tsai SJ (2006) Response to fluoxetine and serotonin 1A receptor (C-1019G) polymorphism in Taiwan Chinese major depressive disorder. Pharmacogenomics J 6:27–33

    Article  PubMed  CAS  Google Scholar 

  12. Huang YY, Battistuzzi C, Oquendo MA, Harkavy-Friedman J, Greenhill L, Zalsman G, Brodsky B, Arango V, Brent DA, Mann JJ (2004) Human 5-HT1A receptor C(-1019)G polymorphism and psychopathology. Int J Neuropsychopharmacol 7:441–451

    Article  PubMed  CAS  Google Scholar 

  13. Joyce JN, Shane A, Lexow N, Winokur A, Casanova MF, Kleinman JE (1993) Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics. Neuropsychopharmacology 8:315–336

    PubMed  CAS  Google Scholar 

  14. Koller G, Bondy B, Preuss UW, Zill P, Soyka M (2006) The C(-1019)G 5-HT1A promoter polymorphism and personality traits: no evidence for significant association in alcoholic patients. Behav Brain Funct 2:7

    Article  PubMed  CAS  Google Scholar 

  15. Lemonde S, Turecki G, Bakish D, Du L, Hrdina PD, Bown CD, Sequeira A, Kushwaha N, Morris SJ, Basak A, Ou XM, Albert PR (2003) Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J Neurosci 23:8788–8799

    PubMed  CAS  Google Scholar 

  16. Nishiguchi N, Shirakawa O, Ono H, Nishimura A, Nushida H, Ueno Y, Maeda K (2002) Lack of an association between 5-HT1A receptor gene structural polymorphisms and suicide victims. Am J Med Genet 114:423–425

    Article  PubMed  Google Scholar 

  17. Pucadyil TJ, Kalipatnapu S, Chattopadhyay A (2005) The serotonin 1A receptor: a representative member of the serotonin receptor family. Cell Mol Neurobiol 25:553–580

    Article  PubMed  CAS  Google Scholar 

  18. Sawiniec J, Borkowski K, Ginalska G, Lewandowska-Stanek H (2007) Association between 5-hydroxytryptamine 1A receptor gene polymorphism and suicidal behavior. Przegl Lek 64:208–211

    PubMed  Google Scholar 

  19. Serretti A, Mandelli L, Giegling I, Schneider B, Hartmann AM, Schnabel A, Maurer K, Moller HJ, Rujescu D (2007) HTR2C and HTR1A gene variants in German and Italian suicide attempters and completers. Am J Med Genet B Neuropsychiatr Genet 144B:291–299

    Article  PubMed  CAS  Google Scholar 

  20. Sunnqvist C, Westrin A, Traskman-Bendz L (2008) Suicide attempters: biological stress markers and adverse life events. Eur Arch Psychiatry Clin Neurosci 258(8):456–462

    Article  PubMed  Google Scholar 

  21. Videtic A, Pungercic G, Pajnic IZ, Zupanc T, Balazic J, Tomori M, Komel R (2006) Association study of seven polymorphisms in four serotonin receptor genes on suicide victims. Am J Med Genet B Neuropsychiatr Genet 141:669–672

    Google Scholar 

  22. Wasserman D, Geijer T, Sokolowski M, Rozanov V, Wasserman J (2007) Nature and nurture in suicidal behavior, the role of genetics: some novel findings concerning personality traits and neural conduction. Physiol Behav 92:245–249

    Article  PubMed  CAS  Google Scholar 

  23. Wasserman D, Geijer T, Sokolowski M, Rozanov V, Wasserman J (2006) The serotonin 1A receptor C(-1019)G polymorphism in relation to suicide attempt. Behav Brain Funct 2:14

    Article  PubMed  CAS  Google Scholar 

  24. World Health Organisation (2008) Health topics. Suicide: Suicide Prevention and Special Programmes, Geneva

  25. Wu S, Comings DE (1999) A common C-1018G polymorphism in the human 5-HT1A receptor gene. Psychiatr Genet 9:105–106

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

The study was supported by the Slovenian Research Agency, program grant No. P1-0104-0381.

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Authors and Affiliations

  1. Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000, Ljubljana, Slovenia

    Alja Videtič &  Radovan Komel PhD

  2. Institute of Forensic Medicine, Faculty of Medicine, University of Ljubljana, Korytkova ulica 2, 1000, Ljubljana, Slovenia

    Tomaž Zupanc & Jože Balažic

  3. University Psychiatric Clinic Ljubljana, Studenec 48, 1260, Ljubljana Polje, Slovenia

    Peter Pregelj & Martina Tomori

Authors
  1. Alja Videtič
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  2. Tomaž Zupanc
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  3. Peter Pregelj
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  4. Jože Balažic
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  5. Martina Tomori
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  6. Radovan Komel PhD
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Correspondence to Radovan Komel PhD.

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Videtič, A., Zupanc, T., Pregelj, P. et al. Suicide, stress and serotonin receptor 1A promoter polymorphism -1019C>G in Slovenian suicide victims. Eur Arch Psychiatry Clin Neurosci 259, 234–238 (2009). https://doi.org/10.1007/s00406-008-0861-4

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  • DOI: https://doi.org/10.1007/s00406-008-0861-4

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