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Dysbindin gene (DTNBP1) and schizophrenia in Korean population

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Abstract

Dysbindin gene (DTNBP1) has been consistently reported to be associated with schizophrenia. However data from East Asian population has been sparse and inconsistent till today. This study tried to replicate the genetic association of DTNBP1 with schizophrenia in a large Korean sample, as well as analyzing the association of DTNBP1 with clinical variables. Nine hundred and eight (908) patients with schizophrenia and 601 controls were investigated. The high-throughput genotyping method using pyrosequencer (Biotage AB, Sweden) was used for genotyping 4 SNPs (rs3213207, rs1011313, rs760761, and rs2619522). Haplotype analyses revealed a significant association with schizophrenia (P < 0.0001) with the haplotypes A-C-C-C and A-C-T-A having an eminent protective effect toward schizophrenia. The major contribution to the difference in the haplotype distribution between patients and the controls was the rs760761 (C/T) and rs2619522 (A/C) haplotypes (P < 0.0001). No association of DTNBP1 with other clinical variables was found. In conclusion, the present study suggests a possible protective effect of rare DTNBP1 variants in schizophrenia, although subsequent studies in different ethnic groups are warranted.

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Acknowledgment

This study was supported by a grant of the Korean Health 21 R&D Project (KPGRN-R-04), Ministry of Health and Welfare, Republic of Korea and by Fondazione del Monte di Bologna e Ravenna (942bis/2007).

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Authors and Affiliations

  1. Department of Psychiatry, The Catholic University of Korea College of Medicine, 505 Banpo-Dong, Seocho-Gu, Seoul, 137-701, South Korea

    Chi-Un Pae, Jung-Jin Kim MD & Tae-Youn Jun MD

  2. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA

    Chi-Un Pae & Ashwin A. Patkar

  3. Institute of Psychiatry, University of Bologna, Bologna, Italy

    Laura Mandelli, Diana De Ronchi & Alessandro Serretti

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  1. Chi-Un Pae
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  2. Laura Mandelli
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  3. Diana De Ronchi
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  4. Jung-Jin Kim MD
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  5. Tae-Youn Jun MD
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  6. Ashwin A. Patkar
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  7. Alessandro Serretti
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Correspondence to Jung-Jin Kim MD.

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Pae, CU., Mandelli, L., De Ronchi, D. et al. Dysbindin gene (DTNBP1) and schizophrenia in Korean population. Eur Arch Psychiatry Clin Neurosci 259, 137–142 (2009). https://doi.org/10.1007/s00406-008-0830-y

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  • DOI: https://doi.org/10.1007/s00406-008-0830-y

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