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Interleukin-1 beta gene polymorphism and its interactions with neuregulin-1 gene polymorphism are associated with schizophrenia

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Abstract

Interleukin-1β (IL-1β) and neuregulin-1 (NRG-1) have an important role in development of the central nervous system. Several recent studies suggest that their genetic polymorphisms are associated with schizophrenia. We studied the effects of the IL-1β gene (IL-1B) -511 and NRG-1 SNP8NRG221533 polymorphisms and their interactions on the risk and age of onset of schizophrenia in 113 Finnish schizophrenic patients and 393 healthy controls. The allele and genotype frequencies of IL-1B and NRG-1 did not differ between schizophrenic patients and healthy controls, but the risk of schizophrenia was more than 10 times higher (odds ratio 10.20, 95% CI 2.53–41.09, p = 0.001) among subjects with the IL-1B 2.2, NRG-1 CC genotypes compared to subjects with the IL-1B 2.2, NRG-1 T-allele carriage. There was also a trend for an association between the interaction between IL-1B and NRG-1 polymorphisms and the age at onset of schizophrenia (χ2 = 2.80; df  = 1; p = 0.09, log rank test). IL-1B-511 allele 1 homozygotes had a significantly higher age of onset than allele 2 carriers (mean age of onset 25.9 ± 7.7 and 22.7 ± 5.4 years, t-test: t = 2.46; p = 0.032). Our results suggest that there is an interaction between the IL-1B and NRG-1 genes in schizophrenia. In addition, the IL-1B-511 polymorphism seems to be associated with the age at onset of schizophrenia.

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Acknowledgments

The study was supported by grants from the Medical Research Foundation of Tampere University Hospital and special governmental grants for health science research at Helsinki University Central Hospital and South Karelia Central Hospital. This work was also supported by grants from the South Karelia Fund of the Finnish Cultural Foundation and the Scholarship Funds of the Vyborg Student Association.

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Authors and Affiliations

  1. Dept. of Psychiatry, South Karelia Central Hospital, Valto Käkelän katu 14 C/6, Lappeenranta, 53130, Finland

    Kari Hänninen MD

  2. Dept. of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland

    Kari Hänninen MD & Heikki Katila MD, PhD

  3. Laboratory of Atherosclerosis Genetics, Centre for Laboratory Medicine, Tampere University Hospital, PL 2000, Tampere, 33521, Finland

    Kari Hänninen MD, Marika Saarela PhD, Riikka Rontu PhD, Kari M. Mattila PhD, Meng Fan MD & Terho Lehtimäki MD, PhD

  4. University of Tampere Medical School, Tampere, Finland

    Marika Saarela PhD, Riikka Rontu PhD, Kari M. Mattila PhD, Meng Fan MD & Terho Lehtimäki MD, PhD

  5. Dept. of Microbiology and Immunology, University of Tampere Medical School, Tampere, Finland

    Mikko Hurme MD, PhD

  6. Tampere University Hospital, Tampere, Finland

    Mikko Hurme MD, PhD

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  1. Kari Hänninen MD
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Correspondence to Kari Hänninen MD.

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Hänninen, K., Katila, H., Saarela, M. et al. Interleukin-1 beta gene polymorphism and its interactions with neuregulin-1 gene polymorphism are associated with schizophrenia. Eur Arch Psychiatry Clin Neurosc 258, 10–15 (2007). https://doi.org/10.1007/s00406-007-0756-9

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  • DOI: https://doi.org/10.1007/s00406-007-0756-9

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