Abstract
This study was designed to examine the correlation between damage to the basal ganglia or frontal lobe and depression status (both affective and apathetic dimensions) in 243 stroke patients. We assessed the affective dimension in post-stroke depression (PSD) using the Zung Self-rating Depression Scale (SDS) and the apathetic dimension in PSD using the apathy scale (AS). We classified basal ganglia or frontal lobe damage into four groups: no damage, damage to the left side only, damage to the right side only, and damage to both sides. Affective and/or apathetic PSD was found in 126 patients (51.9%). The severity of affective depression (SDS score) was associated with left frontal lobe (but not basal ganglia) damage, and that of apathetic depression (AS score) was related to damage to the bilateral basal ganglia (but not to the frontal lobe). The anatomical correlates of PSD differ depending on the PSD dimension (affective or apathetic) and may explain interstudy differences regarding the association between lesion location and type of PSD.
Similar content being viewed by others
References
Alexopoulos GS, Meyers BS, Young RC, Campbell S, Silbersweig D, Charlson M (1997) ‘Vascular depression’ hypothesis. Arch Gen Psychiatry 54:915–922
Bielau H, Trübner K, Krell D, Agelink MW, Bernstein HG, Stauch R, Mawrin C, Danos P, Gerhard L, Bogerts B, Baumann B (2005) Volume deficits of subcortical nuclei in mood disorders: A postmortem study. Eur Arch Psychiatry Clin Neurosci 255:401–412
Biringer E, Lundervold A, Stordal K, Mykletun A, Egeland J, Bottlender R, Lund A (2005) Executive function improvement upon remission of recurrent unipolar depression. Eur Arch Psychiatry Clin Neurosci 255:373–380
Frodl T, Meisenzahl EM, Zetzsche T, Hohne T, Banac S, Schorr C, Jager M, Leinsinger G, Bottlender R, Reiser M, Moller HJ (2004) Hippocampal and amygdala changes in patients with major depressive disorder and healthy controls during a 1-year follow-up. J Clin Psychiatry 65:492–499
Kitamura T, Hirano H, Chen Z, Hirata M (2004) Factor structure of the Zung Self-rating Depression Scale in first-year university students in Japan. Psychiatry Res 128:281–287
Montaner J, Alvarez-Sabín J, Molina C, Anglés A, Abilleira S, Arenillas J, González MA, Monasterio J (2001) Matrix metalloproteinase expression after human cardioembolic stroke: temporal profile and relation to neurological impairment. Stroke 32:1759–1766
Nys GM, van Zandvoort MJ, van der Worp HB, de Haan EH, de Kort PL, Kappelle LJ (2005) Early depressive symptoms after stroke: neuropsychological correlates and lesion characteristics. J Neurol Sci 228:27–33
Robinson RG, Kubos KL, Starr LB, Rao K, Price TR (1984) Mood disorders in stroke patients. Importance of location of lesion. Brain 107:81–93
Sheline YI, Wang PW, Gado MH, Csernansky JG, Vannier MW (1996) Hippocampal atrophy in recurrent major depression. Proc Natl Acad Sci USA 93:3908–3913
Soares JC, Mann JJ (1997) The anatomy of mood disorders-review of structural neuroimaging studies. Biol Psychiatry 41:86–106
Starkstein SE, Robinson RG, Price TR (1987) Comparison of cortical and subcortical lesions in the production of post-stroke mood disorders. Brain 110(Pt 4):1045–1059
Starkstein SE, Fedoroff JP, Price TR, Leiguarda R, Robinson RG (1993) Apathy following cerebrovascular lesions. Stroke 24:1625–1630
Yamagata S, Yamaguchi S, Kobayashi S (2004) Impaired novelty processing in apathy after subcortical stroke. Stroke 35:1935–1940
Yamaguchi S, Kobayashi S, Koide H, Tsunematsu T (1992) Longitudinal study of regional cerebral blood flow changes in depression after stroke. Stroke 23:1716–1722
Acknowledgment
This study was supported by the Ministry of Health, Labour and Welfare, Japan.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Hama, S., Yamashita, H., Shigenobu, M. et al. Post-stroke affective or apathetic depression and lesion location: left frontal lobe and bilateral basal ganglia. Eur Arch Psychiatry Clin Neurosci 257, 149–152 (2007). https://doi.org/10.1007/s00406-006-0698-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00406-006-0698-7