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Impairment of theory of mind in patients in remission following first episode of schizophrenia

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Abstract

The aim of this study was to investigate theory of mind (ToM) ability in patients in remission after the first episode of schizophrenia. A ToM task which contained four pictures was given to 30 patients with schizophrenia in remission and 30 matched healthy controls. Patients with schizophrenia in remission showed statistically significant impairment in the ToM tasks. ToM impairment was not correlated with psychiatric symptoms. Thus, ToM deficit in schizophrenia may be a trait marker.

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References

  1. Abdi Z, Sharma T (2004) Social cognition and its neural correlates in schizophrenia and autism. CNS Spectrum 9:335–343

    Google Scholar 

  2. Abu-Akel A (2003) A neurobiological mapping of theory. Brain Res Rev 43:29–40

    Article  PubMed  Google Scholar 

  3. Brothers L (1990) The social brain: a project for integrating primate behavior and neurophysiology in a new domain. Concepts Neurosci 1:27–51

    Google Scholar 

  4. Brüne M (2003) Theory of mind and the role of IQ in chronic disorganized schizophrenia. Shizophr Res 60:57–64

    Article  Google Scholar 

  5. Dunbar RIM (1998) The social brain hypothesis. Evolutionary Anthropol 6:178–190

    Article  Google Scholar 

  6. Falkai P, Tepest R, Honer WG, Dani I, Ahle G, Pffeiffer U, Vogeley K, Schulze TG, Rietschel M, Cordes J, Schonell H, Gaebel W, Kuhn KU, Maier W, Traber F, Block W, Schild HH, Schneider-Axmann T (2004) Shape changes in prefrontal, but not parieto-occipital regions: brains of schizophrenic patients come closer to a circle in coronal and sagittal view. Psychiat Res 132:261–271

    Google Scholar 

  7. Frith CD, Corcoran R (1996) Exploring ‘theory of mind’ in people with schizophrenia. Psychol Med 26:521–530

    Article  PubMed  CAS  Google Scholar 

  8. Frith CD, Frith U (1999) Interacting minds – a biological basis. Science 286:1692–1695

    Article  PubMed  CAS  Google Scholar 

  9. Herold R, Tenyi T, Lenard K, Trixler M (2002) Theory of mind deficit in people with schizophrenia during remission. Psychol Med 32:1125–1129

    Article  PubMed  CAS  Google Scholar 

  10. Inoue Y, Yamada K, Tonooka Y, Kanba S (2004) Deficiency of theory of mind in patients with remitted mood disorders. J Affect Disord 82:403–409

    PubMed  Google Scholar 

  11. Janssen I, Krabbendam L, Jolles J, Os JV (2003) Alterations in theory of mind in patients with schizophrenia and non-psychotic relatives. Acta Psychiatr Scand 108:110–117

    Article  PubMed  CAS  Google Scholar 

  12. Kawasaki Y, Suzuki M, Nohara S, Hagino H, Takahashi T, Matsui Mie, Yamashita Ikiko, Chitnis XA, McGuire PK, Seto H, Kurachi M (2004) Structural brain differences in patients with schizophrenia and schizotypal disorder demonstrated by voxel-based morphometry. Eur Arch Psychiatry Clin Neurosci 254:406–414

    Article  PubMed  Google Scholar 

  13. Kee KS, Horan WP, Mintz J, Green MF (2004) Do the siblings of schizophrenia patients demonstrate affect perception deficits? Schizophr Res 67:87–94

    Article  PubMed  Google Scholar 

  14. Kelemen O, Kéri S, Must A, Benedek G, Janka Z (2004) No evidence for impaired ‘theory of mind’ in unaffected first-degree relatives of schizophrenia patients. Acta Psychiatr Scand 110:146–149

    Article  PubMed  CAS  Google Scholar 

  15. Kitamura H,Matuzawa H, Shioiri T, Someya T, Kwee IL, Nakada T (2005) Diffusion tensor analysis in chronic schizophrenia A preliminary study on a high-field (3.0T) system. Eur Arch Psychiatry Clin Neurosci (In press)

  16. Lee KH, Farrow TFD, Spence SA, Woodruff PWR (2004) Social cognition brain networks and schizophrenia. Psychol Med 34:391–400

    Article  PubMed  CAS  Google Scholar 

  17. Overall JE, Gorham DR (1962) Brief Psychiatric Rating Scale. Psychol Rep 10:799–812

    Article  Google Scholar 

  18. Pickup GJ, Frith CD (2001) Theory of mind impairments in schizophrenia: symptomatology, severity and specificity. Psychol Med 31:207–220

    Article  PubMed  CAS  Google Scholar 

  19. Pinkham AE, Penn DL, Perkins DO, Lieberman J (2003) Implications for the neural basis of social cognition for the study of schizophrenia. Am J Psychiat 160:815–822

    Article  PubMed  Google Scholar 

  20. Sarfati Y, Hardy-Baylë M-C (1999) How do people with schizophrenia explain the behaviour of others? A study of theory of mind and its relationship to thought and speech disorganization in schizophrenia. Psychol Med 29:613–620

    Article  PubMed  CAS  Google Scholar 

  21. Vogeley K, May M, Ritzl A, Falkai P, Zilles K, Fink GR (2004) Neural correlates of first-person perspective as one constituent of human self-consciousness. J Cog Neurosci 12:529–543

    Google Scholar 

  22. Vogeley K, Tepest R, Schneider-Axmann T, Hutte H, Zilles K, Honer WG, Falkai P (2003) Automated image analysis of disturbed cytorchitecture in Broadmann area 10 in schizophrenia. Schizophr Res 62:133–140

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neuropsychiatry, Graduate School of Medicine and Engineering University of Yamanashi, 1110 Shimokato, Tamaho-cho, Yamanashi 409-3898, Japan

    Y. Inoue, K. Yamada, M. Hirano, M. Shinohara, T. Tamaoki, H. Iguchi & Y. Tonooka

  2. Department of Neuropsychiatry, Graduate School of Medical Sciences Kyushu University, 3-1-1 Maidashi Higashiku, Fukuoka 812-8582, Japan

    S. Kanba

Authors
  1. Y. Inoue
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  2. K. Yamada
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  3. M. Hirano
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  4. M. Shinohara
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  5. T. Tamaoki
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  6. H. Iguchi
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  7. Y. Tonooka
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  8. S. Kanba
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Corresponding author

Correspondence to S. Kanba.

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Inoue, Y., Yamada, K., Hirano, M. et al. Impairment of theory of mind in patients in remission following first episode of schizophrenia. Eur Arch Psychiatry Clin Neurosci 256, 326–328 (2006). https://doi.org/10.1007/s00406-006-0608-z

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  • DOI: https://doi.org/10.1007/s00406-006-0608-z

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