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Polymorphisms in the DBH and DRD2 gene regions and smoking behavior

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Abstract

The DRD2 TaqI A and DBH-1021 C/T polymorphisms were genotyped in smoking alcoholics (N = 100), non–alcoholic smokers (N = 120) and nonsmoking controls (N = 112). Alcoholic and non–alcoholic smokers presented a higher frequency of the DRD2 TaqI A1 allele (P = 0.04) than non–smoking controls. Individuals who had at least one DBH–1021 T allele smoked fewer cigarettes per day than CC homozygotes (P = 0.03). These results are coherent with the expected effects of these polymorphisms on dopaminergic function.

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Authors and Affiliations

  1. Departamento de Genética , Instituto de Biociências, UFRGS, Av. Bento Gonçalves, 9500, Porto Alegre, RS, 91501-970, Brazil

    M. T. M. V. Freire, F. Z. C. Marques, M. H. Hutz & C. H. D. Bau

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  1. M. T. M. V. Freire
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  2. F. Z. C. Marques
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  3. M. H. Hutz
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  4. C. H. D. Bau
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Correspondence to C. H. D. Bau.

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Freire, M.T.M.V., Marques, F.Z.C., Hutz, M.H. et al. Polymorphisms in the DBH and DRD2 gene regions and smoking behavior. Eur Arch Psychiatry Clin Neurosci 256, 93–97 (2006). https://doi.org/10.1007/s00406-005-0610-x

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  • DOI: https://doi.org/10.1007/s00406-005-0610-x

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