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Reboot surgery for chronic rhinosinusitis with nasal polyposis: recurrence and smell kinetics

  • Rhinology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Objective

To evaluate the time for recovery of the sense of smell in patients with CRSwNP who underwent Reboot surgery compared to patients undergoing ESS in a long-term follow-up study.

Methods

Data were collected retrospectively from 168 patients with severe uncontrolled CRSwNP, who underwent revision surgery, either as Extended Endoscopic Sinus Surgery (Reboot, 140 patients) or as regular Endoscopic Sinus Surgery (ESS, 28 patients) between January 1, 2014, and December 31, 2015, aiming to compare the outcome of surgeries after 2 years of follow-up. Sense of smell was scored as judged by the patient using scores 0 to 3 reflecting a percentage estimate of remaining smell.

Results

Smell improved similarly in the Reboot and ESS groups over the first 9 months, which was maintained over 24 months in the Reboot, but not the ESS group (p = 0.007 after 18 months, p = 0.001 after 24 months). Furthermore, polyp recurrence rates were significantly lower in the Reboot group.

Conclusion

Reboot surgery significantly improved olfactory function and significantly reduced nasal polyp recurrence rates over 2 years post-operatively. Therefore, Reboot should be considered for patients with uncontrolled severe CRSwNP, specifically when ESS failed, to offer long-term smell and a polyp-free status.

Level of evidence

3b.

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Funding

Sara Costa Gomes work was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Brazil—Financial code 001, file 88887.570290/2020-00, 6685—PRINT—Institutional program of internationalization, no. 41/2017.

Author information

Authors and Affiliations

  1. Otorhinolaryngology and Ophthalmology Department, Faculty of Medicine, University of Sao Paulo (USP), Sao Paulo, Brazil

    Sara Costa Gomes & Richard Louis Voegels

  2. Department of Sense Organs, Sapienza University of Rome, Rome, Italy

    Carlo Cavaliere

  3. Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy

    Simonetta Masieri

  4. Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium

    Thibaut Van Zele, Philippe Gevaert, Gabriele Holtappels, Nan Zhang & Claus Bachert

  5. Department of Biomolecular Medicine, Faculty of Health Sciences and Medicine, Ghent University, 9000, Ghent, Belgium

    Pathmanaban Ramasamy

  6. Faculty of Medicine, Upper Airways Research Laboratory, Ghent University, 1P1 UZ Gent, MRB2, De Pintelaan 185, 9000, Ghent, Belgium

    Claus Bachert

  7. CLINTEC, Karolinska Institutet, Stockholm, Sweden

    Claus Bachert

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  1. Sara Costa Gomes
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  2. Carlo Cavaliere
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  4. Thibaut Van Zele
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  9. Richard Louis Voegels
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  10. Claus Bachert
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Corresponding author

Correspondence to Claus Bachert.

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Conflict of interest

Carlo Cavalieri declares consultancy for GSK; Claus Bachert is an Advisory Board member and speaker for Novartis, GSK, Astra-Zeneca, Sanofi, ALK, and Mylan. Other authors have no conflict of interest.

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Gomes, S.C., Cavaliere, C., Masieri, S. et al. Reboot surgery for chronic rhinosinusitis with nasal polyposis: recurrence and smell kinetics. Eur Arch Otorhinolaryngol 279, 5691–5699 (2022). https://doi.org/10.1007/s00405-022-07470-z

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  • DOI: https://doi.org/10.1007/s00405-022-07470-z

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