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Oncologic results and quality of life in patients with T3 glottic cancer after transoral laser microsurgery

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Abstract

Purpose

CO2 transoral laser microsurgery (CO2 TOLMS) is an alternative approach to non-surgical organ preservation in selected T3 glottic squamous cell carcinoma (SCC). This study aimed to assess the oncologic results and quality of life (QOL) of patients with T3 glottic SCC after CO2 TOLMS.

Methods

Of the 44 patients who underwent CO2 TOLMS, 38 underwent QOL evaluations. QOL was measured using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 and head and neck module, Voice Handicap Index-30, and M. D. Anderson Dysphagia Inventory at least 6 months postoperatively.

Results

The patients were predominantly male (98%), with a median age of 61 years. Cordectomy type included 1 type III, 4 type IV, 31 type V, and 8 type VI according to European Laryngological Society classification. Two patients (5%) had cervical lymph node metastasis and 21 patients (48%) underwent postoperative radiotherapy. With a mean follow-up of 65 months for all patients, 10 (23%) had tumor recurrence (9 local, 1 distant). After salvage surgery, four patients lived without disease, and the larynx was preserved in two. The 5-year local control and overall and disease-specific survival rates were 78%, 75%, and 84%, respectively. The overall laryngeal preservation rate was 82% (36/44). Most patients had satisfactory QOL.

Conclusions

In selected T3 glottic SCC cases, CO2 TOLMS can achieve favorable oncologic results and a satisfactory QOL.

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Funding

This study is supported by grants from the Taipei Veterans General Hospital (V108C-002) and kindly financial supported by Dr. Morris Chang and Sophie Chang, which had no involvement and conflict of interests in this study.

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Authors and Affiliations

  1. Department of Otolaryngology–Head and Neck Surgery, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan

    Pei-Ju Chien, Li-Ting Hung & Pen-Yuan Chu

  2. Department of Oncology Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

    Ling-Wei Wang & Muh-Hwa Yang

  3. National Yang-Ming University, Taipei, Taiwan

    Ling-Wei Wang & Muh-Hwa Yang

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  1. Pei-Ju Chien
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Correspondence to Pen-Yuan Chu.

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Chien, PJ., Hung, LT., Wang, LW. et al. Oncologic results and quality of life in patients with T3 glottic cancer after transoral laser microsurgery. Eur Arch Otorhinolaryngol 278, 2983–2992 (2021). https://doi.org/10.1007/s00405-020-06445-2

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