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Evaluation of nasal mucociliary clearance time in patients with Vitamin-D deficiency

  • Rhinology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Objectives

The main purpose of the current study was to investigate nasal mucociliary clearance time (NMC) in patients with Vitamin-D deficiency.

Methods

A total of 55 patients with Vitamin-D deficiency and 32 controls were evaluated. NMC time was measured with subjective saccharine test and compared between study and control groups. In addition, NMC time was re-evaluated after Vitamin-D replacement protocol in patients with Vitamin-D deficiency.

Results

The mean 25(HO)Vitamin-D levels were 14.32 ± 4.23 ng/mL (7–24.6) and 29.38 ± 7.05 ng/mL (25–53.8) in study and control groups, respectively (p < 0.001). The mean NMC time was 11.15 ± 3.05 (6.3–17.6) and 8.40 ± 2.33 (6–13.2) in study and control groups, respectively (p < 0.001). The mean 25(HO)Vitamin-D level after the replacement protocol was 33.38 ± 10.03 and the mean NMC time was 9.56 ± 2.54 (p < 0.001).

Conclusion

The mean NMC time was significantly increased in patients with Vitamin-D deficiency which can be corrected after Vitamin-D replacement protocols. The prolonged mucociliary clearance might be one of the pathophysiologic pathways at increased upper respiratory tract infections, and sinonasal and ear infections in patients with Vitamin-D deficiency.

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Acknowledgements

All authors would like to thank Dr. Uche Nwagu for her English revisions.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Düzce University School of Medicine, Düzce, Turkey

    Fatih Alper Akcan, Derya Cebeci & İlhan Ünlü

  2. Department of Otolaryngology–Head and Neck Surgery, Wayne State University, Detroit, MI, USA

    Yusuf Dündar

  3. Department of Internal Medicine, Ministry of Health, Atatürk Hospital, Düzce, Turkey

    Hümeyra Bayram Akcan

  4. Department of Otolaryngology, Ministry of Health, Balıkesir Hospital, Balıkesir, Turkey

    Ahmet Uluat

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  1. Fatih Alper Akcan
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  2. Yusuf Dündar
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Correspondence to Fatih Alper Akcan.

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Ethical approval

This article contains studies with human participants and local ethics committee approval was obtained before the study.

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Informed consent was obtained from all individual participants included in the study.

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Akcan, F.A., Dündar, Y., Akcan, H.B. et al. Evaluation of nasal mucociliary clearance time in patients with Vitamin-D deficiency. Eur Arch Otorhinolaryngol 276, 1075–1080 (2019). https://doi.org/10.1007/s00405-019-05286-y

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