Skip to main content
SpringerLink
Log in

Survival analysis of distant metastasis of laryngeal carcinoma: analysis based on SEER database

  • Laryngology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Background

The purpose of this study was to investigate the prognostic factors and the value of surgical treatment of patients with newly diagnosed laryngeal cancer with distant metastasis (DM).

Methods

The Surveillance, Epidemiology and End Result database (SEER) was used to analyze 446 patients with laryngeal cancer with DM at the time of initial diagnosis from 2010 to 2014.The survival prognosis of patients with DM was performed by using Kaplan–Meier and log-rank test. The prognostic factors and the effect of surgery were analyzed using the Cox regression analysis and R-language data package.

Results

The incidence of DM was 3.21% (446/13865). Lung was the most common distant metastatic site of laryngeal cancer (62.6%), and brain metastases had the worst prognosis in patients at 2 months. T stage and brain metastasis were independent risk factors affecting the survival (P < 0.05). The hazard ratio (HR) of DM in T4 stage was nearly twice than that in T1 stage. Surgical treatment of primary and metastatic tumors can cause better survival for patients. Patients who didn’t underwent primary tumor surgery were approximately twice as likely to die from cancer as those who did. The nomogram model was constructed to visually present the 1-, 2- and 3-year survival rates of patients.

Conclusions

T stage, brain metastasis and surgical treatment are prognostic factors of patients with M1 stage laryngeal cancer. Surgical treatment of primary tumors and metastases can lead to better survival for patients.

Trial registration

Not applicable.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

Abbreviations

DM:

Distant metastasis

SEER:

The Surveillance, Epidemiology and End Result database

OS:

Overall survival

CSS:

Cancer-specific survival

HR:

Hazard ratio

95% CI:

95% confidence interval

MST:

Median survival time

KPS:

Karnofsky score

References

  1. Cosetti M, Yu GP, Schantz SP (2008) Five-year survival rates and time trends of laryngeal cancer in the US population. Arch Otolaryngol Head Neck Surg 134(4):370–379

    Article  PubMed  Google Scholar 

  2. Siegel RL, Miller KD, Jemal A (2018) Cancer statistics, 2018. CA Cancer J Clin 68(1):7–30

    Article  Google Scholar 

  3. Abramson AL, Parisier SC, Zamansky MJ, Sulka M (1971) Distant metastases from carcinoma of the larynx. Laryngoscope 81(9):1503–1511

    Article  CAS  PubMed  Google Scholar 

  4. Yücel OT, Yilmaz T, Unal OF, Turan E (1999) Distant metastases in laryngeal squamous cell carcinoma. J Exp Clin Cancer Res 18(3):285–288

    PubMed  Google Scholar 

  5. Lahoz ZMT, Galve RF, Martínez SJ, Laguía PM (2001) Distant metastases in patients with advance laryngeal carcinoma. Acta Otorrinolaringol Esp 52(4):307–311

    Article  Google Scholar 

  6. Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF (2017) An update on larynx cancer. CA Cancer J Clin 67(1):31–50

    Article  PubMed  Google Scholar 

  7. Spector JG, Sessions DG, Haughey BH, Chao KS, Simpson J, El MS, Perez CA (2001) Delayed regional metastases, distant metastases, and second primary malignancies in squamous cell carcinomas of the larynx and hypopharynx. Laryngoscope 111(6):1079–1087

    Article  CAS  PubMed  Google Scholar 

  8. Yilmaz T, Hoşal S, Ozyar E, Akyol F, Gürsel B (2005) Post-operative radiotherapy in advanced laryngeal cancer: effect on local and regional recurrence, distant metastases and second primaries. J Laryngol Otol 119(10):784–790

    Article  PubMed  Google Scholar 

  9. León X, Quer M, Orús C, del PVM, López M (2000) Distant metastases in head and neck cancer patients who achieved loco-regional control. Head Neck 22(7):680–686

    Article  PubMed  Google Scholar 

  10. Spector GJ (2001) Distant metastases from laryngeal and hypopharyngeal cancer. ORL J Otorhinolaryngol Relat Spec 63(4):224–228

    Article  CAS  PubMed  Google Scholar 

  11. Li XM, Di B, Shang YD, Zhou YQ, Ma HM, Cheng JM (2004) Analysis of risk factors in the prediction of distant metastases of head and neck squamous cell carcinomas. Zhonghua Er Bi Yan Hou Ke Za Zhi 39(3):171–175

    PubMed  Google Scholar 

  12. Li X, Di B, Shang Y, Zhou Y, Cheng J, He Z (2009) Clinicopathologic risk factors for distant metastases from head and neck squamous cell carcinomas. Eur J Surg Oncol 35(12):1348–1353

    Article  CAS  PubMed  Google Scholar 

  13. Lee DH, Kim MJ, Roh JL, Kim SB, Choi SH, Nam SY, Kim SY (2012) Distant metastases and survival prediction in head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg 147(5):870–875

    Article  PubMed  Google Scholar 

  14. Takes RP, Rinaldo A, Silver CE, Haigentz M, Woolgar JA, Triantafyllou A, Mondin V, Paccagnella D, de Bree R, Shaha AR, Hartl DM, Ferlito A (2012) Distant metastases from head and neck squamous cell carcinoma. Part I. Basic aspects. Oral Oncol 48(9):775–779

    Article  PubMed  Google Scholar 

  15. Fortin A, Couture C, Doucet R, Albert M, Allard J, Tetu B (2001) Does histologic grade have a role in the management of head and neck cancers. J Clin Oncol 19(21):4107–4116

    Article  CAS  PubMed  Google Scholar 

  16. Liu WW, Zeng ZY, Guo ZM, Xu GP, Yang AK, Zhang Q (2003) Distant metastases and their significant indicators in laryngeal cancer. Zhonghua Er Bi Yan Hou Ke Za Zhi 38(3):221–224

    PubMed  Google Scholar 

  17. Matsuo JM, Patel SG, Singh B, Wong RJ, Boyle JO, Kraus DH, Shaha AR, Zelefsky MJ, Pfister DG, Shah JP (2003) Clinical nodal stage is an independently significant predictor of distant failure in patients with squamous cell carcinoma of the larynx. Ann Surg 238(3):412–421 (discussion 421–422)

    PubMed  PubMed Central  Google Scholar 

  18. Brouwer J, Bree R, Hoekstra OS, Langendijk JA, Castelijns JA, Leemans CR (2005) Screening for distant metastases in patients with head and neck cancer: what is the current clinical practice. Clin Otolaryngol 30(5):438–443

    Article  CAS  PubMed  Google Scholar 

  19. Imre A, Pinar E, Dincer E, Ozkul Y, Aslan H, Songu M, Tatar B, Onur I, Ozturkcan S, Aladag I (2016) Lymph node density in node-positive laryngeal carcinoma: analysis of prognostic value for survival. Otolaryngol Head Neck Surg 155(5):797–804

    Article  PubMed  Google Scholar 

  20. Shiono S, Kawamura M, Sato T, Okumura S, Nakajima J, Yoshino I, Ikeda N, Horio H, Akiyama H, Kobayashi K (2009) Pulmonary metastasectomy for pulmonary metastases of head and neck squamous cell carcinomas. Ann Thorac Surg 88(3):856–860

    Article  PubMed  Google Scholar 

Download references

Funding

Not applicable.

Author information

Author notes

  1. Yafeng Pan and Yuming Hong equally contributed to this work.

Authors and Affiliations

  1. Department of Otolaryngology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China

    Yafeng Pan, Yuming Hong & Zhenyuan Liang

  2. Department of Urology, The Second Affiliated Hospital of Fujian Medical University, Licheng District Zhongshan North Road, Quanzhou, 362000, Fujian, China

    Wei Zhuang

Authors
  1. Yafeng Pan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yuming Hong
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Zhenyuan Liang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Wei Zhuang
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

YP: formal analysis, project administration, writing original draft, and writing review and editing. YH: design of the epidemiological investigation and formal analysis. ZL: conceptualization, supervision, data curation and validation. WZ: data curation, methodology, software, project administration, and writing review and editing.

Corresponding author

Correspondence to Wei Zhuang.

Ethics declarations

Conflict of interest

The authors declare that they have no competing interests.

Ethics approval and consent to participate

All procedures performed in studies involving human participants conform to the standards of the institutional and national ethics committees, as well as to the 1964 Helsinki Declaration and subsequent relevant ethics. Patient informed consent is not required to extract data from the SEER database.

Consent for publication

All authors are informed and consent for publication.

Availability of data and material

All data were acquired from the SEER database. We obtained the authorization to access the SEER database with the number 14260-Nov2016.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pan, Y., Hong, Y., Liang, Z. et al. Survival analysis of distant metastasis of laryngeal carcinoma: analysis based on SEER database. Eur Arch Otorhinolaryngol 276, 193–201 (2019). https://doi.org/10.1007/s00405-018-5244-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00405-018-5244-5

Keywords

Search

Navigation