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The comparison of single-dose preemptive intravenous ibuprofen and paracetamol on postoperative pain scores and opioid consumption after open septorhinoplasty: a randomized controlled study

  • Rhinology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

Septorhinoplasty is performed in combination with septoplasty and rhinoplasty operations and is characterized by severe postoperative pain. The aim of this study is to evaluate preemptive effects of intravenous (IV) ibuprofen and IV paracetamol on opioid consumption and pain scores after open septorhinoplasty.

Methods

The study included 150 patients who had undergone elective open septorhinoplasty. Patients were randomly assigned into three groups; Group Control (Group C, n = 50) received 100 ml saline solution, Group Paracetamol (Group P, n = 50) received 1000 mg IV paracetamol in 100 ml solution, and Group Ibuprofen (Group I, n = 50) received 800 mg IV ibuprofen in 100 ml saline before surgery. Postoperative analgesia was achieved by opioid administration via patient-controlled analgesia. Visual analog scores (VASs), postoperative opioid consumption, additional analgesic requirements, and side effects were recorded.

Results

Compared with Group C, VASs in Group P and Group I were statistically lower at all time points (p < 0.05). VAS was lower in Group I than in Group P at postoperative, 1st and 6th hours (p < 0.05). Opioid consumption in Group C was highest in all groups at all time periods (p < 0.05). At the 0–6 and 6–12 time intervals, total opioid consumption was significantly lower in Group I compared to Group P (p < 0.05). Total opioid consumption was highest in Group C (p < 0.05).

Conclusions

This study has indicated that ibuprofen has more analgesic effect than paracetamol during first 12 h, but there is a non-inferiority between ibuprofen and paracetamol after first 12 h.

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Authors and Affiliations

  1. Department of Anesthesiology and Reanimation, Erzurum Regional Training and Research Hospital, Erzurum, Turkey

    Erkan Cem Çelik, Duygu Kara & Ahmet Murat Yayik

  2. Otorhinolaryngology Department, Palandoken State Hospital, Erzurum, Turkey

    Ersen Koc

Authors
  1. Erkan Cem Çelik
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  2. Duygu Kara
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  3. Ersen Koc
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  4. Ahmet Murat Yayik
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All of the authors declare that they have all participated in the design, execution, and analysis of the paper, and that they have approved the final version.

Corresponding author

Correspondence to Erkan Cem Çelik.

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The authors declare no competing interest. No financial support was received for this paper.

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Çelik, E.C., Kara, D., Koc, E. et al. The comparison of single-dose preemptive intravenous ibuprofen and paracetamol on postoperative pain scores and opioid consumption after open septorhinoplasty: a randomized controlled study. Eur Arch Otorhinolaryngol 275, 2259–2263 (2018). https://doi.org/10.1007/s00405-018-5065-6

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  • DOI: https://doi.org/10.1007/s00405-018-5065-6

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