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Supracricoid partial laryngectomy for radiorecurrent laryngeal cancer: a systematic review of the literature and meta-analysis

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Abstract

Purpose

The objective of the current systematic review with meta-analysis was to report the pooled survival outcomes of supracricoid partial laryngectomy in the setting of radiorecurrent laryngeal cancer to investigate if and when an organ-sparing surgical treatment is adequate.

Methods

The search included all original papers from 1990 to December 2017. The search terms included the following: cricohyoepiglottopexy; cricohyoidopexy; cricohyopexy; horizontal laryngectomy; and partial, subtotal, supracricoid, and supraglottic laryngectomy. Inclusion criteria were as follows: (1) data clearly distinguish results of partial laryngeal procedures; (2) clear description of tumor stage and selection criteria; (3) clear description or derivability of local control and survival rates.

Results

Eleven out of 270 papers were analyzed, and a total of 251 cases were included. Two-year LC, 3-year DFS, and 5-year OS were 92, 80, and 79%, respectively. Heterogenicity evaluated with the I2 parameter was 14, 0, 0%, respectively. The larynx preservation rate was 85.2%, the decannulation rate was 92.1%, and swallowing recovery was 96.5% (PEG dependence and the aspiration pneumonia rate were 3.5 and 6.4%, respectively).

Conclusions

SCPL is oncologically sound, guaranteeing a high percentage of success. The homogeneity of data should encourage the use of SCPL as salvage treatment for recurrent LSCC.

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Acknowledgements

The authors exclude any relevant financial activities outside the submitted work.

Funding

The present is a self-funded study.

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Authors and Affiliations

  1. Otorhinolaryngology Unit, Humanitas Clinical and Research Center, Viale Manzoni 56, 20089, Rozzano, MI, Italy

    Armando De Virgilio

  2. Department of Otolaryngology-Head and Neck Surgery, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy

    Raul Pellini, Giuseppe Mercante, Giovanni Cristalli, Valentina Manciocco & Giuseppe Spriano

  3. Department of Biostatistics and Bioinformatics, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy

    Diana Giannarelli

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  1. Armando De Virgilio
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  2. Raul Pellini
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  3. Giuseppe Mercante
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  4. Giovanni Cristalli
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  5. Valentina Manciocco
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  7. Giuseppe Spriano
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Correspondence to Armando De Virgilio.

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De Virgilio, A., Pellini, R., Mercante, G. et al. Supracricoid partial laryngectomy for radiorecurrent laryngeal cancer: a systematic review of the literature and meta-analysis. Eur Arch Otorhinolaryngol 275, 1671–1680 (2018). https://doi.org/10.1007/s00405-018-4986-4

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  • DOI: https://doi.org/10.1007/s00405-018-4986-4

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