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Does severity of cerebral MRI lesions in congenital CMV infection correlates with the outcome of cochlear implantation?

  • Otology
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European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

The objective is to investigate whether there is a correlation between the severity of typical brain lesions in congenital cytomegalovirus (cCMV) infection and cochlear implant (CI) outcome. The design of the study is a retrospective single-institutional chart review (2005–2015), performed in a tertiary academic referral center. 23 children with typical signs of cCMV infection on cerebral magnetic resonance imaging (MRI) and bilateral severe-to-profound sensorineural hearing loss were retrospectively evaluated. They were graded in three groups according to the severity of brain involvement. The average implantation age of the first CI is 1.8 years (range 0.6–5.8). Five patients were implanted unilaterally, 18 bilaterally. The average follow-up time after implantation was 3.3 years (range 0.6–6.9). Hearing performance was assessed using the Categories of Auditory Performance (CAP), and speech development was assessed using Speech Intelligibility Rating (SIR). The outcome in each group showed great variation. The majority of children achieved moderate-to-good auditory and speech rehabilitation. The children with severe MRI changes had comparatively better auditory than speech scores. There were children with good auditory performance (CAP ≥6) both in grades II and III, while poor performers (CAP ≤3) were encountered in each group. The severity of brain lesions on its own does not directly correlate with the outcome of cochlear implantation. Despite good retrospective diagnostic evidence of cCMV infection through MRI patterns, this has no predictive role for future hearing and speech rehabilitation.

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Authors and Affiliations

  1. Department of Otolaryngology, Hannover Medical School, Hannover, Germany

    Stefan Lyutenski, Alexandros Giourgas, Omid Majdani & Thomas Lenarz

  2. Department of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany

    Friedrich Götz, Eva Bültmann, Heinrich Lanfermann & Anja M. Giesemann

Authors
  1. Stefan Lyutenski
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  2. Friedrich Götz
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  3. Alexandros Giourgas
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  4. Omid Majdani
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  5. Eva Bültmann
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  6. Heinrich Lanfermann
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  7. Thomas Lenarz
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  8. Anja M. Giesemann
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Corresponding author

Correspondence to Anja M. Giesemann.

Ethics declarations

The study was approved by our institutional ethic committee (Number: 3363-2016) and is in accordance with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Research involving human participants, approved by our institutional ethic committee (3363-2016).

Conflict of interest

The authors declare that they have no conflict of interest.

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Lyutenski, S., Götz, F., Giourgas, A. et al. Does severity of cerebral MRI lesions in congenital CMV infection correlates with the outcome of cochlear implantation?. Eur Arch Otorhinolaryngol 274, 1397–1403 (2017). https://doi.org/10.1007/s00405-016-4408-4

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  • DOI: https://doi.org/10.1007/s00405-016-4408-4

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