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Protective role of misoprostol against cisplatin-induced ototoxicity

  • Otology
  • Published:
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Abstract

Cis-diammineedichloroplatinum (cisplatin) is a chemotherapeutic agent that is widely used in the treatment of many cancers. Nephrotoxicity, ototoxicity and neurotoxicity are dose-limiting adverse effects for cisplatin. The cellular and molecular mechanisms underlying cisplatin-induced ototoxicity aren’t fully understood. It has been proposed that cisplatin primarily cause damage at the cochlea, outer hair cells in particular, leading to excessive production of free oxygen radicals in the organ of Corti, stria vascularis, spiral ligament, and spiral ganglionic cells. The cytotoxicity is associated with the generation of reactive oxygen species (ROS); thus, there is an increasing interest on antioxidants with an effort to discover the established protection against cisplatin-induced ototoxicity over time. Misoprostol (MP) has gained considerable interest as a reactive oxygen species scavenger in recent years. To best of our knowledge, there is no study about protective effect of MP, a prostaglandin E1 (PGE1) analogue, on cisplatin-induced ototoxicity. In our study, we show that protective effects of misoprostol on cisplatin-induced ototoxcity on rats.

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Authors and Affiliations

  1. Department of ENT, Kayseri Training and Research Hospital, Kayseri, Turkey

    Murat Doğan, Halil Polat, Mehmet Yaşar, Altan Kaya, Ali Bayram & İbrahim Özcan

  2. Department of Pathology, Kayseri Training and Research Hospital, Kayseri, Turkey

    Fatma Şenel

  3. Kayseri Eğitim ve Araştırma Hastanesi KBB Kliniği Sanayi Mah. Atatürk Bulvarı Hastane Cad. No: 78 38010, Kayseri, Turkey

    Murat Doğan

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  1. Murat Doğan
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  3. Mehmet Yaşar
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Correspondence to Murat Doğan.

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This study was funded by Kayseri Training and Research Hospital.

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All applicable international, national and/or institutional guidelines for care and use of animals were followed.

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Doğan, M., Polat, H., Yaşar, M. et al. Protective role of misoprostol against cisplatin-induced ototoxicity. Eur Arch Otorhinolaryngol 273, 3685–3692 (2016). https://doi.org/10.1007/s00405-016-4031-4

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  • DOI: https://doi.org/10.1007/s00405-016-4031-4

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