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Factors affecting recurrence of sinonasal inverted papilloma

  • Rhinology
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Abstract

The aim is to study clinical characteristics and recurrence rates for sinonasal inverted papilloma (NIP), to evaluate relevant factors for its recurrence, and to compare the curative rates of different surgical approaches. The Krouse classification for the 156 follow-up cases of the patients with NIP was as following: 26 cases in T1, 33 cases in T2, 94 cases in T3, and 3 cases in T4. A total number of 99 cases of endoscopic sinus surgery were included, of which 26 cases of lateral rhinotomy approach were combined with Caldwell Luc approach, and 31 cases of nasal endoscopy combined with traditional surgery, with average postoperative follow-up of 3–11 years. Of the 156 studied patients with NIP, male:female = 1.69:1, age varied from 18 to 77 years, with average of 56 years, 19 cases showed postoperative recurrence, of which 8 cases developed to be squamous cell carcinoma. Among these 8 cases, 3 patients showed no recurrence after treatment in 5 years, and the other 5 patients died in 3–2 years period. Tumor recurrence rates for different surgical approach are: 9.09 % for endoscopic surgical group, 23.08 % for traditional surgical group, and 12.12 % for combined surgical group; tumor malignancy rates for different surgical approach are: 2.02 % for endoscopic surgical group, 11.54 % traditional surgical group, and 9.09 % for combined group, and Chi-square test showed that the differences in recurrence and malignancy rates for NIP patients with different surgical treatments were not statistically significant (P > 0.05). Recurrence rates for different stages are: T1 at 3.85 %, T2 at 12.12 %, T3 at 14.89 %, and T4 at 0.00 %, and the differences in the recurrence rates for different stages were not statistically significant (P > 0.05) by Chi-square test. There are clear clinical features for NIP, and the recurrence is related to the thoroughness of the first time surgical removal of lesions and is less relevant with Krouse classification stage and surgical approaches.

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References

  1. Outzen KE, Grontveld A, Jorgensen K, Clausen PP, Ladefoged C (1996) Inverted papilloma: incidence and late results of surgical treatment. Rhinology 34(2):114–118

    PubMed  CAS  Google Scholar 

  2. Baruah P, Deka RC (2003) Endoscopic management of inverted papillomas of the nose and paranasal sinuses. Ear Nose Throat J 82(4):317–320

    PubMed  Google Scholar 

  3. Von Buchwald C, Bradley PJ (2007) Risk of malignancy in inverted papilloma of the nose and paranasal sinuses. Curr Opin Otolaryngol Head Neck Surg 15(2):95–98

    Article  Google Scholar 

  4. Krouse JH (2000) Development of a staging system for inverted papilloma. Laryngoscope 110(6):965–968

    Article  PubMed  CAS  Google Scholar 

  5. Cai YC, Zhang J (2011) Recurrent factors of inverted papilloma of nasal cavity and paranasal sinuses. Int J Dermatol Venereol 35(3):167–169

    Google Scholar 

  6. Mirza S, Bradley PJ, Acharya A et al (2007) Sinonasal inverted papillomas: recurrence, and synchronous and metachronous malignancy. J Laryngol Otol 121(9):857–864

    Article  PubMed  CAS  Google Scholar 

  7. Zhang CQ, Liu BB, Liu Y et al (2005) Management of sinonasal inverted papilloma: endoscopic excision vs traditional procedures. Chin J Otorhinolaryngol Head Neck Surg 40(4):283–285

    Google Scholar 

  8. Xu G, Li Y, Shi JB et al (1996) Endoscopic sinus surgery for the treatment of inverted papilloma of nasal cavity and paranasal sinuses. Chin J Otorhinolaryngol 31(4):237–239

    CAS  Google Scholar 

  9. Busquets JM, Hwang PH (2006) Endoscopic resection of sinonasal inverted papilloma:a meta-analysis. Otolaryngol Head Neck Surg 134(3):476–482

    Article  PubMed  Google Scholar 

  10. Han JK, Tl Smith, Loehrl T et al (2001) An evolution in the management of sinonasal inverting papilloma. Laryngoscope 111:1395–1400

    Article  PubMed  CAS  Google Scholar 

  11. Yuan H, Wang RG (2002) Management of sinonasal inverting papilloma with recurrence and malignant transformation. Chin J Otorhinolaryngol 37(3):202–205

    Google Scholar 

  12. Gomez JA, Mendenhall WM, Tannehill SP et al (2000) Radiation therapy in inverted papillomas of the nasal cavity and paranasal sinuses. Am J Otolaryngol 21:174–178

    Article  PubMed  CAS  Google Scholar 

Download references

Conflict of interest

The authors have no conflicts of interest to declare. We have no financial relationship with the organization that sponsored the research.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, China

    Wang Xiao-Ting, Wei Xiu-Qing, Wang Hai-Bo, Pang Wen-Hui, Li Bing, Zhang Er-Peng & Shi Guang-Gang

  2. Department of Otolaryngology Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, Guangdong, China

    Li Peng

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  1. Wang Xiao-Ting
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  2. Li Peng
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  3. Wei Xiu-Qing
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  4. Wang Hai-Bo
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  5. Pang Wen-Hui
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  6. Li Bing
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  7. Zhang Er-Peng
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  8. Shi Guang-Gang
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Corresponding author

Correspondence to Shi Guang-Gang.

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W. Xiao-Ting and L. Peng are joint first authors.

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Xiao-Ting, W., Peng, L., Xiu-Qing, W. et al. Factors affecting recurrence of sinonasal inverted papilloma. Eur Arch Otorhinolaryngol 270, 1349–1353 (2013). https://doi.org/10.1007/s00405-012-2216-z

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  • DOI: https://doi.org/10.1007/s00405-012-2216-z

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