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The changing surgical management of juvenile nasopharyngeal angiofibroma

  • Head and Neck
  • Published:
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Abstract

The management of juvenile nasopharyngeal angiofibroma (JNA) has changed during the last decades but it still continues to be a challenge for the multidisciplinary head and neck surgical team. The aim of this study was to review the used treatment approach and outcome of JNA in a single institution series of 27 patients diagnosed and treated during the years 1970–2009. All patients were male, with the median age of 17 years (range 11–33 years). Surgery was used as the primary treatment in every case. Surgical approaches varied, transpalatal approach (N = 14) being the most common approach used in this series. During the last decade various other techniques were applied, including endoscopic (N = 3) resection. Two patients were additionally treated with antiangiogenic agents and one patient with stereotactic radiotherapy. The primary recurrence rate was 37% and it seemed to correlate with vascular density of tumour and the surgical approach used. We suggest that the management of JNA should be planned by an experienced head and neck surgeon, as part of a multidisciplinary team, preferably in a tertiary referral setting, and the recent development of the available therapies should be taken into account to minimise the risk of recurrence.

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Acknowledgment

This study was supported by The Helsinki University Central Hospital Research Fund, Helsinki, Finland.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Head and Neck Surgery, Helsinki University Central Hospital and University of Helsinki, P.O. Box 220, 00029, Helsinki, Finland

    Suvi Renkonen & Antti A. Mäkitie

  2. Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland

    Jaana Hagström & Ilmo Leivo

  3. Department of Plastic Surgery, Helsinki University Central Hospital, Helsinki, Finland

    Jyrki Vuola

  4. Department of Neurosurgery, Helsinki University Central Hospital, Helsinki, Finland

    Mika Niemelä

  5. Department of Neuroradiology, Helsinki University Central Hospital, Helsinki, Finland

    Matti Porras

  6. Division of Hem/Onc and SCT, Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland

    Sanna-Maria Kivivuori

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  1. Suvi Renkonen
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Correspondence to Antti A. Mäkitie.

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Renkonen, S., Hagström, J., Vuola, J. et al. The changing surgical management of juvenile nasopharyngeal angiofibroma. Eur Arch Otorhinolaryngol 268, 599–607 (2011). https://doi.org/10.1007/s00405-010-1383-z

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  • DOI: https://doi.org/10.1007/s00405-010-1383-z

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