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The evaluation of vestibular functions in patients with pseudoexfoliation syndrome

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

The main objective of the study is to evaluate vestibular system of the inner ear with postural tests in the patients with pseudoexfoliation syndrome (PEX). It is clinical case–control study. The study group included 34 patients with PEX and 40 controls without PEX. The patients and controls underwent complete ophthalmic and otorhinolaryngologic examinations. Vestibular functions were done by Fitzgerald and Dix-Hallpike, caloric tests, Romberg test, tandem Gait test, Quiks test in both control and study groups. Pur-tone and high-frequency audiography were also performed in all cases. The mean patient age was 63 years (±11.80) (range 47–74 years) in the PEX group and 65 years (±8.70) (range 61–68 years) in the control group with no differences among the two groups (P > 0.05). Although none of the 34 patients with PEX had clinical history of balance disturbance, 21 (61.76%) had significant pathologic sign in vestibular function tests (P ≤ 0.05), while only 3 (7.5%) of 40 cases in the control group had pathologic sign in vestibular function tests. The scales from pure tone and high-frequency audiogram in the PEX group were similar to those of the control group. In conclusion, the patients with PEX, there may be a vestibular involvement in the pathological level in the inner ear. Larger clinical studies, experimental animal studies, and post mortem studies in humans are needed to disclose the pathology in the vestibulocochlear system in the patients with PEX.

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References

  1. Lindberg JG (1917) Clinical studies of depigmentation of the pupillary margin and transillumination of the iris in cases of senile cataract and also in normal eyes of the aged. MD Thesis, Dissertation Helsingfors, Helsinki University, Finland

  2. Ritch R, Schlötzer-Schrehardt U (2001) Exfoliation syndrome. Surv Ophthalmol 45:265–315

    Article  CAS  PubMed  Google Scholar 

  3. Kling F, Colin J (2001) Potential association of pseudoexfoliation syndrome (PEX) with age-related macular degeneration (ARMD). J Fr Opthalmol 24:7–12

    CAS  Google Scholar 

  4. Aasved H (1971) Mass screening for fibrillopathia epitheliocapsularis, so-called senile exfoliation or pseudoexfoliation of the anterior lens capsule. Acta Ophthalmol (Copenh) 49:334–343

    Article  CAS  Google Scholar 

  5. Forsius H (1979) Prevalence of pseudoexfoliation of the lens in Finns, Lapps, Icelanders, Eskimos, and Russians. Trans Ophthalmol Soc UK 99:296–298

    CAS  PubMed  Google Scholar 

  6. Kozobolis VP, Papatzanaki M, Vlachonikolis IG et al (1997) Epidemiology of pseudoexfoliation in the island of Crete (Greece). Acta Ophthalmol Scand 75:726–729

    Article  CAS  PubMed  Google Scholar 

  7. Mccarty CA, Taylor HR (2000) Pseudoexfoliation syndrome in Australian adults. Am J Ophthalmol 129:629–633

    Article  CAS  PubMed  Google Scholar 

  8. Nouri-Mahdavi K, Nosrat N, Sahebghalam R et al (1999) Pseudoexfoliation syndrome in central Iran: a population-based survey. Acta Ophthalmol Scand 77:581–584

    Article  CAS  PubMed  Google Scholar 

  9. Yalaz M, Othman I, Nas K et al (1992) The frequency of pseudoexfoliation syndrome in the eastern Mediterranean area of Turkey. Acta Ophthalmol (Copenh) 70:209–213

    Article  CAS  Google Scholar 

  10. Schlotzer-Schrehardt UM, Koca MR, Naumann GO et al (1992) Pseudoexfoliation syndrome: ocular manifestation of a systemic disorder? Arch Ophthalmol 110:1752–1756

    CAS  PubMed  Google Scholar 

  11. Streeten BW, Li ZY, Wallace RN et al (1992) Pseudoexfoliative fibrillopathy in visceral organs of a patient with pseudoexfoliation syndrome. Arch Ophthalmol 110:1757–1762

    CAS  PubMed  Google Scholar 

  12. Streeten BW, Dark AJ, Wallace RN et al (1990) Pseudoexfoliative fibrillopathy in the skin of patients with ocular pseudoexfoliation. Am J Ophthalmol 110:490–499

    CAS  PubMed  Google Scholar 

  13. Schumacher S, Schlotzer-Schredhardt U, Martus P et al (2001) Pseudoexfoliation syndrome and aneurysms of the abdominal aorta. Lancet 357:359–360

    Article  CAS  PubMed  Google Scholar 

  14. Mitchell P, Wang JJ, Smith W (1997) Association of pseudoexfoliation syndrome with increased vascular risk. Am J Ophthalmol 124:685–687

    CAS  PubMed  Google Scholar 

  15. Citirik M, Acaroglu G, Batman C et al (2007) A possible link between pseudoexfoliation syndrome and coronary artery disease. Eye 21:11–15

    Article  CAS  PubMed  Google Scholar 

  16. Janciauskiene S, Krakau T (2003) Alzheimer’s peptide and serine proteinase inhibitors in glaucoma and exfoliation syndrome. Doc Ophthalmol 106:215–223

    Article  PubMed  Google Scholar 

  17. Repo LP, Terasvirta ME, Koivisto KJ (1993) Generalized transluminance of the iris and the frequency of the pseudoexfoliation syndrome in the eyes of transient ischemic attack patients. Ophthalmology 100:352–355

    CAS  PubMed  Google Scholar 

  18. Linner E, Popovic V, Gottfries CG et al (2001) The exfoliation syndrome in cognitive impairment of cerebrovascular or Alzheimer’s type. Acta Ophthalmol Scand 79:283–285

    Article  CAS  PubMed  Google Scholar 

  19. Schlotzer-Schrehardt U, Neumann GO (2006) Ocular and systemic pseudoexfoliation syndrome. Am J Ophthalmol 141:921–937

    Article  PubMed  Google Scholar 

  20. Houk JC (1988) Control strategies in physiological systems. FASEB J 2:97

    CAS  PubMed  Google Scholar 

  21. Nashner LM (1985) Strategies for organization of human posture. In: Igarashi M, Black FO (eds) Vestibular and visual control on posture and locomotor equilibrium. S Karger, Basel

    Google Scholar 

  22. Larsen WJ (1998) Development of the head, the neck, the eyes and the ears. In: Larsen WJ, Sherman LS, Potter SS, Scott WJ (eds) Essentials of embryology. Churchill Livingstone, New York, pp 229–272

  23. Akyıldız AN (1998) Isitme ve denge organlarının embriyolojisi. Kulak Hastalıkları ve Mikrocerrahisi, 1. Bilimsel Tıp Yayınevi, Baskı, pp 17–21

  24. Seth RS, Dayal D (1978) Inner ear involvement in primary glaucoma. Ear Nose Throat J 57:355–359

    CAS  PubMed  Google Scholar 

  25. Cahill M, Early A, Stack S et al (2002) Pseudoexfoliation and sensorineural hearing loss. Eye 16:261–266

    Article  CAS  PubMed  Google Scholar 

  26. Shaban RI, Asfour WM (2004) Ocular pseudoexfoliation associated with hearing loss. Saudi Med J 25:1254–1257

    PubMed  Google Scholar 

  27. Geribeyoglu L, Uzun AM, Evren O et al (2005) Sensorineural hearing loss in pseudoexfoliation syndrome and glaucoma. Turkiye Klinikleri J Med Sci 25:800–805

    Google Scholar 

  28. Cummings Charlen W, Jhon M (1993) Otologic and neurotologic history and physical examination. In: House JW et al (eds) Otolaryngology head and neck surgery, 2nd edn. St. Louis, Mosby-Year Book Inc, pp 2648–2667

    Google Scholar 

  29. Aydogan Ozkan B, Yuksel N, Keskin G et al (2006) Homocysteine levels in plasma and sensorineural hearing loss in patients with pseudoexfoliation syndrome. Eur J Ophthalmol 16:542–547

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, Faculty of Medicine, Fırat University, Elazig, Turkey

    Burak Turgut, Mehmet Kaan Kaya & Ulku Celiker

  2. Department of Otorhinolaryngology, Faculty of Medicine, Fırat University, 23119, Elazig, Turkey

    Hayrettin Cengiz Alpay, Muzaffer Oger & Sinasi Yalcin

Authors
  1. Burak Turgut
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  2. Hayrettin Cengiz Alpay
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  3. Mehmet Kaan Kaya
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  4. Muzaffer Oger
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  5. Ulku Celiker
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  6. Sinasi Yalcin
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Correspondence to Hayrettin Cengiz Alpay.

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Turgut, B., Alpay, H.C., Kaya, M.K. et al. The evaluation of vestibular functions in patients with pseudoexfoliation syndrome. Eur Arch Otorhinolaryngol 267, 523–527 (2010). https://doi.org/10.1007/s00405-009-1093-6

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  • DOI: https://doi.org/10.1007/s00405-009-1093-6

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