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Unilateral sudden hearing loss as the first sign of chronic myeloid leukemia

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Abstract

Chronic myeloid leukemia (CML) is one of the etiologic causes of sudden hearing loss and vertigo. However, deafness in association with vestibular symptoms rarely occurs in CML as the first sign. In this article, a 50-year-old male with CML whose first signs and symptoms were unilateral sudden hearing loss and tinnitus in the right ear, vertigo and nausea was presented. Aetiopathogenetic mechanisms, clinical and radiological aspects and therapeutic options for CML with deafness and vertigo were discussed reviewing the literature.

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References

  1. Andres E, Kurtz JE, Maloisel F, Dufour P. (2001) Otological manifestations of acute leukaemia: report of two cases and review of literature. Clin Lab Haematol 23:7–60

    Article  Google Scholar 

  2. Baer MR, Stein RS, Dessypris EN (1985) Chronic lymphocytic leukemia with hyperleukocytosis. The hyperviscosity syndrome. Cancer 15:2865–2869

    Article  Google Scholar 

  3. Chae SW, Cho JH, Lee JH, Kang HJ, Hwang SJ. (2002) Sudden hearing loss in chronic myelogenous leukaemia implicating the hyperviscosity syndrome. J Laryngol Otol 116:291–293

    Article  PubMed  Google Scholar 

  4. Chim CS, Woo JKS (1997) Deafness in chronic myeloid leukemia. Leuk Lymphoma 26:209–210

    PubMed  CAS  Google Scholar 

  5. Genden EM, Bahadori RS (1995) Bilateral sensorineural hearing loss as a first symptom of chronic myelogenous leukemia. Otolaryngol Head Neck Surg 113:499–501

    Article  PubMed  CAS  Google Scholar 

  6. Gotay V (1976) Unusual otologic manifestation of chronic lymphocytic leukemia. Laryngoscope 86:1856–1863

    PubMed  CAS  Google Scholar 

  7. Kanyike FB, Kigonya RM (1982) Nerve deafness, dysarthria and ataxia in chronic granulocytic leukaemia case report. East Afr Med J 59:420–424

    PubMed  CAS  Google Scholar 

  8. Naithani R, Chandra J, Mathur NN, Narayan S, Singh V. (2005) Hearing loss in chronic myeloid leukemia. Pediatr Blood Cancer 45:54–56

    Article  PubMed  Google Scholar 

  9. Paparella MM, Berlinger NT, Oda M, el-Fiky F (1973) Otological manifestations of leukemia. Laryngoscope 83:1510–1526

    Article  PubMed  CAS  Google Scholar 

  10. Preston FE, Sokol RJ, Lilleyman JS, Winfield DA, Blackburn EK (1978) Cellular hyperviscosity as a cause of neurological symptoms in leukaemia. Br Med J 25:76–78

    Google Scholar 

  11. Resende LS, Coradazzi AL, Rocha-Junior C, Zanini JM, Niero-Melo L (2000) Sudden bilateral deafness from hyperleukocytosis in chronic myeloid leukemia. Acta Haematol 104:6–9

    Article  Google Scholar 

  12. Veling MC, Windmill I, Bumpous JM (1999) Sudden hearing loss as a presenting manifestation of leukemia. Otolaryngol Head Neck Surg 120:954–956

    Article  PubMed  CAS  Google Scholar 

  13. Williams CKO, Ogan O (1985) Chronic myelogenous leukemia associated with impairment of hearing. Br Med J 290:1705

    Article  CAS  Google Scholar 

  14. Yamada K, Kaga K, Suzuki J (1994) Temporal bone pathology in patients without caloric response. Acta Otolaryngol 114:586–594

    PubMed  CAS  Google Scholar 

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Correspondence to Gül Özbilen Acar.

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Acar, G.Ö., Acıoğlu, E., Enver, Ö. et al. Unilateral sudden hearing loss as the first sign of chronic myeloid leukemia. Eur Arch Otorhinolaryngol 264, 1513–1516 (2007). https://doi.org/10.1007/s00405-007-0382-1

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  • DOI: https://doi.org/10.1007/s00405-007-0382-1

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