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Mesenchymal stem cells in iatrogenic facial nerve paralysis: a possible role in the future

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Abstract

Iatrogenic facial nerve paralysis is one of the major and drastic complications of ear surgery. We report a case of a 20-year-old female patient with simple chronic otitis media who underwent mastoidectomy and tympanoplasty. During the mastoidectomy process the facial nerve was unintentionally destroyed, leaving a gap of 8–10 mm in the third segment of the intratemporal facial nerve. The nerve was repaired with a nerve cable graft obtained from the vicinity. On the 42nd day, autologous mesenchymal stem cell transplantation was performed after facial nerve trauma. The patient’s facial nerve paralysis has recovered from House-Brackmann grade VI to IV within a week and then to III in the fifth month. The rapid, postoperative progress, and the early follow-up results are discussed. This case represents the first bone marrow stem cell application in a peripheral nerve, namely the facial nerve.

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References

  1. Brackmann DE, Hitselberger WE, Robinson JV (1978) Facial nerve repair in cerebellopontine angle surgery. Ann Otol Rhinol Laryngol 87:772–777

    PubMed  CAS  Google Scholar 

  2. Chen X, Katakowski M, Li Y, Lu D, Wang L, Zhang L, Chen J, Xu Y, Gautam S, Mahmood A, Chopp M (2002) Human bone marrow stromal cell cultures conditioned by traumatic brain tissue extracts: growth factor production. J Neurosci Res 69:687–691

    Article  PubMed  CAS  Google Scholar 

  3. Chen X, Li Y, Wang L, Katakowski M, Zhang L, Chen J, Xu Y, Gautam SC, Chopp M (2002) Ischemic rat brain extracts induce human marrow stromal cell growth factor production. Neuropathology 22:275–279

    Article  PubMed  Google Scholar 

  4. Cowan CA, Atienza J, Melton DA, Eggan K (2005) Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science 309:1369–1373

    Article  PubMed  CAS  Google Scholar 

  5. Cuevas P, Carceller F, Dujovny M, Garcia-Gomez I, Cuevas B, Gonzalez-Corrochano R, Diaz-Gonzalez D, Reimers D (2002) Peripheral nerve regeneration by bone marrow stromal cells. Neurol Res 24:634–638

    Article  PubMed  Google Scholar 

  6. Cuevas P, Carceller F, Garcia-Gomez I, Yan M, Dujovny M (2004) Bone marrow stromal cell implantation for peripheral nerve repair. Neurol Res 26:230–232

    Article  PubMed  Google Scholar 

  7. Dezawa M, Takahashi I, Esaki M, Takano M, Sawada H (2001) Sciatic nerve regeneration in rats induced by transplantation of in vitro differentiated bone-marrow stromal cells. Eur J Neurosci 14:1771–1776

    Article  PubMed  CAS  Google Scholar 

  8. Falcioni M, Taibah A, Russo A, Piccirillo E, Sanna M (2003) Facial nerve grafting. Otol Neurotol 24:486–489

    Article  PubMed  Google Scholar 

  9. Kamada T, Koda M, Dezawa M, Yoshinaga K, Hashimoto M, Koshizuka S, Nishio Y, Moriya H, Yamazaki M (2005) Transplantation of bone marrow stromal cell-derived Schwann cells promotes axonal regeneration and functional recovery after complete transection of adult rat spinal cord. J Neuropathol Exp Neurol 64:37–45

    PubMed  Google Scholar 

  10. Kinnaird T, Stabile E, Burnett MS, Epstein SE (2004) Bone-marrow-derived cells for enhancing collateral development: mechanisms, animal data, and initial clinical experiences. Circ Res 95:354–363

    Article  PubMed  CAS  Google Scholar 

  11. Lindvall O, Bjorklund A (2004) Cell replacement therapy: helping the brain to repair itself. NeuroRx 1:379–381

    Article  PubMed  Google Scholar 

  12. Mazzini L, Fagioli F, Boccaletti R, Mareschi K, Oliveri G, Olivieri C, Pastore I, Marasso R, Madon E (2003) Stem cell therapy in amyotrophic lateral sclerosis: a methodological approach in humans. Amyotroph Lateral Scler Other Motor Neuron Disord 4:158–161

    Article  PubMed  Google Scholar 

  13. Mazzini L, Fagioli F, Boccaletti R (2004) Stem-cell therapy in amyotrophic lateral sclerosis. Lancet 364:1936–1937

    Article  PubMed  Google Scholar 

  14. Myckatyn TM, Mackinnon SE, McDonald JW (2004) Stem cell transplantation and other novel techniques for promoting recovery from spinal cord injury. Transpl Immunol 12:343–358

    Article  PubMed  CAS  Google Scholar 

  15. Regala C, Duan M, Zou J, Salminen M, Olivius P (2005) Xenografted fetal dorsal root ganglion, embryonic stem cell and adult neural stem cell survival following implantation into the adult vestibulocochlear nerve. Exp Neurol 193:326–333

    Article  PubMed  CAS  Google Scholar 

  16. Roskams AJ, Tetzlaff W (2005) Directing stem cells and progenitor cells on the stage of spinal cord injury. Exp Neurol 193:267–272

    Article  PubMed  CAS  Google Scholar 

  17. Sanchez-Ramos J, Song S, Cardozo-Pelaez F, Hazzi C, Stedeford T, Willing A, Freeman TB, Saporta S, Janssen W, Patel N, Cooper DR, Sanberg PR (2000) Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol 164:247–256

    Article  PubMed  CAS  Google Scholar 

  18. Satake K, Lou J, Lenke LG (2004) Migration of mesenchymal stem cells through cerebrospinal fluid into injured spinal cord tissue. Spine 29:1971–1979

    Article  PubMed  Google Scholar 

  19. Ying QL, Nichols J, Evans EP, Smith AG (2002) Changing potency by spontaneous fusion. Nature 416:545–548

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Otolaryngology, Karadeniz Technical University, Tip Fakultesi, KBB Anabilim Dali, Trabzon, Turkey

    Refik Caylan & Devrim Bektas

  2. Division of Hematology, Department of Internal Medicine, Karadeniz Technical University, Trabzon, Turkey

    Tamer Dikmen, Serdar B. Omay & Ercument Ovali

  3. Department of Internal Medicine, Karadeniz Technical University, Trabzon, Turkey

    Ozlen Bektas

Authors
  1. Refik Caylan
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  2. Devrim Bektas
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  3. Tamer Dikmen
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  4. Ozlen Bektas
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  5. Serdar B. Omay
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  6. Ercument Ovali
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Correspondence to Refik Caylan.

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Caylan, R., Bektas, D., Dikmen, T. et al. Mesenchymal stem cells in iatrogenic facial nerve paralysis: a possible role in the future. Eur Arch Otorhinolaryngol 263, 963–967 (2006). https://doi.org/10.1007/s00405-006-0093-z

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  • DOI: https://doi.org/10.1007/s00405-006-0093-z

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