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Influence of epidemiological characteristics (age, parity and other factors) in the assessment of healthy uterine cervical stiffness evaluated through shear wave elastography as a prior step to its use in uterine cervical pathology

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Abstract

Purpose

The purpose of this study was to evaluate stiffness changes occurring in the healthy uterine cervix according to age, parity, phase of the menstrual cycle and other factors by shear wave elastography (SWE).

Methods

Evaluations of cervical speed and stiffness measurements were performed in 50 non-pregnant patients without gynaecological pathology using SWE transvaginal ultrasound. We performed the evaluation in the midsagittal plane of the uterine cervix with measurements at 0.5, 1 and 1.5 cm from external cervical os, at both anterior and posterior cervical lips.

Results

We evaluated 44 patients by SWE and obtained a total average velocity of 3.48 ± 1.08 m/s and stiffness of 42.39 ± 25.33 kPa. We found differences in speed and stiffness according to the cervical lip and depth evaluated; thus, we observed a velocity of 2.70 m/s at 0.5 cm of depth in the anterior lip and 3.53 m/s at 1.5 cm of depth in the posterior lip (p < 0.05). We observed differences according to parity, obtaining a wave transmission speed of 2.67 m/s and 4.41 m/s at the cervical canal of nulliparous and multiparous patients, respectively (p < 0 0.002). We observed differences according to patient age (from a speed of 2.75 m/s at the cervical canal in the age group of 20–35 years to 5.05 m/s in the age group > 50 years) (p < 0.008). We did not observe differences in speed or stiffness according to the phase of the menstrual cycle, BMI, smoking status or the presence or absence of non-HPV infections.

Conclusions

The wave transmission speed and stiffness of the uterine cervix evaluated by SWE varies according to the cervical lip and depth of the evaluation as well as according to the parity and age of the patient.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Valme University Hospital, Seville, Spain

    Laura Castro, José Antonio García-Mejido, Eva Arroyo, Jara Carrera & José Antonio Sainz

  2. Biostatistics Unit, Department of Preventive Medicine and Public Health, University of Seville, Seville, Spain

    José Antonio García-Mejido & Ana Fernández-Palacín

  3. Department of Obstetrics and Gynecology, University of Seville, Seville, Spain

    José Antonio Sainz

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  1. Laura Castro
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Correspondence to José Antonio García-Mejido.

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This study was approved by the Biomedical Ethics Committee of Andalucía.

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Castro, L., García-Mejido, J.A., Arroyo, E. et al. Influence of epidemiological characteristics (age, parity and other factors) in the assessment of healthy uterine cervical stiffness evaluated through shear wave elastography as a prior step to its use in uterine cervical pathology . Arch Gynecol Obstet 302, 753–762 (2020). https://doi.org/10.1007/s00404-020-05671-7

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