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RETRACTED ARTICLE: Impact of maternal nutrition in hepatitis E infection in pregnancy

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

This article was retracted on 02 February 2023

This article has been updated

Abstract

Background and aim

The basis of host response in hepatitis E virus (HEV)—related liver disease during pregnancy—is still unclear. The study aims to evaluate anthropometric parameters and biochemical nutritional parameters in hepatitis E infection during pregnancy and correlate it with severity of the disease.

Methods

A total of consecutive 267 pregnant women with jaundice were recruited. The jaundiced patients were classified as acute viral hepatitis (AVH) or acute liver failure (ALF). The study group included 144 pregnant women with HEV infection and 144 healthy asymptomatic age and gestational age-matched pregnant women as controls. Nutritional factors were evaluated on basis of anthropometric parameters and biochemical factors. Serum prealbumin and folate were assayed by ELISA kit.

Results

All nutritional parameters were significantly lower in pregnant women with HEV infection as compared with healthy pregnant controls. Some of the nutritional parameters significantly lower in ALF pregnant patients compared to AVH pregnant patients in HEV group. Linear regression analysis of the AVH group showed that serum total protein and mid-upper arm circumference (MUAC) were significant predictors for bilirubin, body mass index (BMI) could significantly predict viral load level, and total protein, prealbumin, folate, and tricep skin fold thickness (TSFT) could significantly predict prothrombin time. In ALF group, serum prealbumin could significantly predict bilirubin levels and MUAC could significantly predict prothrombin time.

Conclusion

Malnutrition might confer a higher predisposition for HEV infection during pregnancy and is associated with increased severity of disease in terms of occurrence of ALF.

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Acknowledgements

This research study was supported by the grant-in-aid of Indian Council of Medical Research, New Delhi, India.

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, 110002, India

    Ashok Kumar, Sheetal Sharma & Sudha Prasad

  2. Department of Medicine, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, 110002, India

    Premashish Kar

  3. Department of Biochemistry, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, 110002, India

    Sarita Agarwal

  4. Department of Neonatology, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, 110002, India

    Siddhartha Ramji

  5. Department of Biosciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India

    Syed Akhtar Husain

  6. National Institute of Cancer Prevention and Research (NICPR) ICMR, Sector-39, Noida, Uttar Pradesh, 201301, India

    Shashi Sharma

  7. 13B, DDA Flats, Ber Sarai, New Delhi, 110016, India

    Ashok Kumar

Authors
  1. Ashok Kumar
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  2. Sheetal Sharma
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  7. Sudha Prasad
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  8. Shashi Sharma
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Contributions

Kumar A: protocol/project development and manuscript writing/editing. Sharma S: data collection, data analysis, and manuscript writing/editing. Kar P: protocol/project development. Agarwal S: protocol/project development and data analysis. Ramji S: protocol/project development and manuscript review. Husain S A: project development and manuscript review. Prasad S: protocol/project development; Sharma S: data analysis.

Corresponding author

Correspondence to Ashok Kumar.

Ethics declarations

Ethical standards

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Declaration of Helsinki, as revised in 2008 (5). Informed consent was obtained from all patients included in the study. This article does not contain any studies with animal subjects.

Funding

This study was funded by the grant-in-aid of Indian Council of Medical Research, New Delhi, India (Grant Number: 5/7/585/11-RHN, dated 27.03.2012).

Conflict of interest

Ashok Kumar, Sheetal Sharma, Premashish Kar, Sarita Agarwal, Siddhartha Ramji, Syed Akhtar Husain, Sudha Prasad, and Shashi Sharma declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Kumar, A., Sharma, S., Kar, P. et al. RETRACTED ARTICLE: Impact of maternal nutrition in hepatitis E infection in pregnancy. Arch Gynecol Obstet 296, 885–895 (2017). https://doi.org/10.1007/s00404-017-4501-y

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  • DOI: https://doi.org/10.1007/s00404-017-4501-y

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