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Pregnancy outcomes in oocyte recipients with fibroids not impinging uterine cavity

  • Gynecologic Endocrinology and Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objective

To examine the effects of fibroid uterus on pregnancy outcomes and endometrial features in ovum donation recipients.

Methods

Retrospective analysis of 744 ovum donation cycles was conducted in two private IVF centers between 2005 and 2012. All the recipients underwent transvaginal ultrasound examination, including endometrial thickness and grade measurements. Clinical pregnancy, spontaneous miscarriage, and live birth rates were regarded as the primary outcomes.

Results

Leimyomas not distorting the uterine cavity were diagnosed in 264 (35.5%) of the cycles. This group exhibited lower endometrial thickness (8.33 ± 1.8 vs. 8.73 ± 2.03 mm, p = 0.009), lower rates of Grade A (16.1 vs. 30.1%, p < 0.0001), and higher rates of grade C endometrium (10.2 vs. 5.5%, p < 0.0001), compared to the group with sonographically normal uterine cavity. In addition, significantly higher spontaneous miscarriage rates were found in fibroid uteri group (25 vs. 14.5%, p = 0.036).

Conclusion

Our study results suggest that uterine fibroids not distorting the uterine cavity could constitute a risk factor for spontaneous miscarriage in oocyte donation cycles, possibly via their adverse effect on endometrial receptivity. Further well-designed trials should widely explore this subject, particularly focusing on impact of myomectomy on fertility rates in these patients.

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Authors and Affiliations

  1. Division of Fertility-In Vitro Fertilization, Department of Obstetrics and Gynecology, Faculty of Medicine, Carmel Medical Center, Technion, Michal St., Haifa, Israel

    Lena Sagi-Dain & Martha Dirnfeld

  2. St Georges Hospital, London, UK

    Kamal Ojha

  3. Division of Fertility-In Vitro Fertilization, Faculty of Medicine, Sheba Medical Centre, Tel Aviv, Israel

    David Bider & Jacob Levron

  4. In Vitro Fertilization Centre, Isida, Kiev, Ukraine

    Viktor Zinchenko

  5. The London Bridge Gynecology Fertility and Genetic Centre, London, UK

    Kamal Ojha & Sharon Walster

  6. Department of Obstetrics and Gynecology, Bnai Zion Medical Center, Haifa, Israel

    Shlomi Sagi

Authors
  1. Lena Sagi-Dain
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  2. Kamal Ojha
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  3. David Bider
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  4. Jacob Levron
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  5. Viktor Zinchenko
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  6. Sharon Walster
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  7. Shlomi Sagi
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  8. Martha Dirnfeld
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Corresponding author

Correspondence to Lena Sagi-Dain.

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Funding

No funding was received for this study.

Conflict of interest

All authors declared that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Given the retrospective design, written informed consent was not required.

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Sagi-Dain, L., Ojha, K., Bider, D. et al. Pregnancy outcomes in oocyte recipients with fibroids not impinging uterine cavity. Arch Gynecol Obstet 295, 497–502 (2017). https://doi.org/10.1007/s00404-016-4273-9

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  • DOI: https://doi.org/10.1007/s00404-016-4273-9

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