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Lactobacilli vaginal colonisation after oral consumption of Respecta® complex: a randomised controlled pilot study

  • General Gynecology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

The aim of the current pilot study was to determine if oral consumption of a combination of two probiotics; L. acidophilus La-14, L. rhamnosus HN001, and bovine lactoferrin (Respecta® complex), would lead to the detection with molecular techniques of the consumed probiotic strains in the vagina.

Methods

Healthy volunteers (40) consumed the study product twice daily for 2 weeks. Vaginal swabs were collected at 0, 1, 2 and 3 weeks and analysed for the consumed organisms by qPCR.

Results

Vaginal L. rhamnosus and L. acidophilus levels were significantly increased on days 14 and 21. On days 14 and 21 a significant number of women had increased levels of vaginal L. acidophilus and on days 7 and 21 a significant number of women had increased levels of vaginal L. rhamnosus.

Conclusions

Consumption of L. acidophilus La-14, L. rhamnosus HN001 in combination with bovine lactoferrin leads to vaginal detection; even 1 week after consumption was stopped. This provides a basis for future studies on urogenital tract health.

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Acknowledgments

We are grateful to the volunteers for their participation.

Conflict of interest

The study was sponsored by Giellepi S.p.A.; Giellepi is the owner of the investigated product. RR and FT are employees of Giellepi. ACO is an employee of DuPont Nutrition & Health; DuPont manufactures and markets probiotics. The sponsor and the author had no influence on the interpretation of the results.

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Authors and Affiliations

  1. Struttura complessa ostetricia e ginecologia, Ospedale SS. Antonio e Biagio, Alessandria (AL), Italy

    Davide De Alberti

  2. Farcoderm Srl, European Expertise Network for Wellness and Dermatology, San Martino Siccomario (PV), Italy

    Davide De Alberti & Vincenzo Nobile

  3. Giellepi S.p.A. Health Science, via Verdi 41Q, Seregno (MB), Italy

    Rosario Russo & Fabio Terruzzi

  4. Active Nutrition, DuPont Nutrition and Health, Sokeritehtaantie 20, 02460, Kantvik, Finland

    Arthur C. Ouwehand

Authors
  1. Davide De Alberti
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  2. Rosario Russo
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  3. Fabio Terruzzi
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  4. Vincenzo Nobile
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  5. Arthur C. Ouwehand
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Corresponding author

Correspondence to Arthur C. Ouwehand.

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De Alberti, D., Russo, R., Terruzzi, F. et al. Lactobacilli vaginal colonisation after oral consumption of Respecta® complex: a randomised controlled pilot study. Arch Gynecol Obstet 292, 861–867 (2015). https://doi.org/10.1007/s00404-015-3711-4

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  • DOI: https://doi.org/10.1007/s00404-015-3711-4

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