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Expression of p27 and Jun activation domain-binding protein 1 in endometriosis

  • General Gynecology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objective

The goal of this study was to investigate differential expression of the cell cycle signaling proteins p27 and Jun activation domain-binding protein 1 (Jab1) in benign ovarian cysts of patients with endometriosis compared to controls.

Methods

Ovarian tissues of 26 endometriosis and 28 non-endometriosis patients were used to evaluate expression of p27 and Jab1 by immunohistochemistry.

Results

There are no differences in clinical characteristics between the endometriosis and non-endometriosis group. In the endometriosis group, CD10, Jab1 and p27 were positive in 50, 48.3 and 57.7 % of cases, respectively, compared to 14.3, 17.9 and 50 %, respectively, in the non-endometriosis group. Jab1 and p27 were positive in 69.2 and 84.6 %, respectively, of the definite endometriosis cases.

Conclusions

These results demonstrate that Jab1 expression was increased in endometriosis, while p27 expression was similar in the endometriosis and non-endometriosis groups.

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References

  1. Lee W, Park E, Kim D, Kim T, Lee H, Chung S (2011) Expression of p53, p27 and Jab1 protein in epithelial ovarian tumors. Eur J Gynaecol Oncol 33:358–362

    Google Scholar 

  2. Emberley ED, Niu Y, Leygue E, Tomes L, Gietz RD, Murphy LC et al (2003) Psoriasin interacts with Jab1 and influences breast cancer progression. Cancer Res 63:1954–1961

    CAS  PubMed  Google Scholar 

  3. Borriello A, Bencivenga D, Criscuolo M, Caldarelli I, Cucciolla V, Tramontano A et al (2011) Targeting p27Kip1 protein: its relevance in the therapy of human cancer. Expert Opin Ther Targets 15:677–693

    Article  CAS  PubMed  Google Scholar 

  4. Masciullo V, Sgambato A, Pacilio C, Pucci B, Ferrandina G, Palazzo J et al (1999) Frequent loss of expression of the cyclin-dependent kinase inhibitor p27 in epithelial ovarian cancer. Cancer Res 59:3790–3794

    CAS  PubMed  Google Scholar 

  5. Rassidakis GZ, Claret FX, Lai R, Zhang Q, Sarris AH, McDonnell TJ et al (2003) Expression of p27(Kip1) and c-Jun activation binding protein 1 are inversely correlated in systemic anaplastic large cell lymphoma. Clin Cancer Res 9:1121–1128

    CAS  PubMed  Google Scholar 

  6. Kouvaraki MA, Korapati AL, Rassidakis GZ, Tian L, Zhang Q, Chiao P et al (2006) Potential role of Jun activation domain-binding protein 1 as a negative regulator of p27kip1 in pancreatic adenocarcinoma. Cancer Res 66:8581–8589

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Jeon JH, Lee KN, Hwang CY, Kwon KS, You KH, Choi I (2005) Tumor suppressor VDUP1 increases p27(kip1) stability by inhibiting JAB1. Cancer Res 65:4485–4489

    Article  CAS  PubMed  Google Scholar 

  8. Sui L, Dong Y, Ohno M, Watanabe Y, Sugimoto K, Tai Y et al (2001) Jab1 expression is associated with inverse expression of p27(kip1) and poor prognosis in epithelial ovarian tumors. Clin Cancer Res 7:4130–4135

    CAS  PubMed  Google Scholar 

  9. Shaulian E, Karin M (2002) AP-1 as a regulator of cell life and death. Nat Cell Biol 4:E131–E136

    Article  CAS  PubMed  Google Scholar 

  10. Beliard A, Noel A, Foidart JM (2004) Reduction of apoptosis and proliferation in endometriosis. Fertil Steril 82:80–85

    Article  PubMed  Google Scholar 

  11. Walter AJ, Hentz JG, Magtibay PM, Cornella JL, Magrina JF (2001) Endometriosis: correlation between histologic and visual findings at laparoscopy. Am J Obstet Gynecol 184:1407–1413

    Article  CAS  PubMed  Google Scholar 

  12. Chu P, Arber DA (2000) Paraffin-Section Detection of CD10 in 505 Nonhematopoietic Neoplasms Frequent Expression in Renal Cell Carcinoma and Endometrial Stromal Sarcoma. Am J Clin Pathol 113:374–382

    Article  CAS  PubMed  Google Scholar 

  13. Sumathi V, McCluggage W (2002) CD10 is useful in demonstrating endometrial stroma at ectopic sites and in confirming a diagnosis of endometriosis. J Clin Pathol 55:391–392

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  14. Groisman GM, Meir A (2003) CD10 is helpful in detecting occult or inconspicuous endometrial stromal cells in cases of presumptive endometriosis. Arch Pathol Lab Med 127:1003–1006

    PubMed  Google Scholar 

  15. McCluggage W, Sumathi V, Maxwell P (2001) CD10 is a sensitive and diagnostically useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms. Histopathology 39:273–278

    Article  CAS  PubMed  Google Scholar 

  16. Schor E, da Silva ID, Sato H, Baracat EC, Girao MJ, de Freitas V (2009) P27Kip1 is down-regulated in the endometrium of women with endometriosis. Fertil Steril 91:682–686

    Article  PubMed  Google Scholar 

  17. Camargo-Kosugi CM, da Silva ID, Sato H, D’Amora P, Carvalho CV, Nogueira-de-Souza NC et al (2009) The V109G polymorphism in the p27 gene is associated with endometriosis. Eur J Obstet Gynecol Reprod Biol 145:180–183

    Article  CAS  PubMed  Google Scholar 

  18. Matsuzaki S, Canis M, Murakami T, Dechelotte P, Bruhat MA, Okamura K (2001) Expression of the cyclin-dependent kinase inhibitor p27Kip1 in eutopic endometrium and peritoneal endometriosis. Fertil Steril 75:956–960

    Article  CAS  PubMed  Google Scholar 

  19. Shiozawa T, Nikaido T, Nakayama K, Lu X, Fujii S (1998) Involvement of cyclin-dependent kinase inhibitor p27Kip1 in growth inhibition of endometrium in the secretory phase and of hyperplastic endometrium treated with progesterone. Mol Hum Reprod 4:899–905

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

This work was supported in part by the Soonchunhyang University Research Fund (20130617). This work was partly supported by Jeil Pharmacy.

Conflict of interest

The authors declare no conflicts of interest.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon, 420-767, Republic of Korea

    Tae-Hee Kim, Hae-Hyeog Lee, Soo-Ho Chung, Junsik Park & Arum Lee

  2. Department of Interdisciplinary Program in Biomedical Science, Soonchunhyang University Graduate School, Asan, 336-745, Republic of Korea

    Arum Lee

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  1. Tae-Hee Kim
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  2. Hae-Hyeog Lee
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  3. Soo-Ho Chung
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  4. Junsik Park
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  5. Arum Lee
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Correspondence to Hae-Hyeog Lee.

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Kim, TH., Lee, HH., Chung, SH. et al. Expression of p27 and Jun activation domain-binding protein 1 in endometriosis. Arch Gynecol Obstet 292, 377–381 (2015). https://doi.org/10.1007/s00404-015-3642-0

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  • DOI: https://doi.org/10.1007/s00404-015-3642-0

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