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Association of calcitonin receptor gene polymorphism with bone mineral density in postmenopausal Chinese women: a meta-analysis

  • Gynecologic Endocrinology and Reproductive Medicine
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Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Background

The relationship between Calcitonin receptor (CTR) gene polymorphism C1377T and bone mineral density (BMD) in postmenopausal women has been studied to some degree in Western countries, but the reports remain inconclusive and have not been generalized to other populations.

Purpose

To evaluate the association of CTR gene polymorphism C1377T with BMD in the Han Chinese population.

Methods

We searched for all published articles indexed in MEDLINE (1950–2014), EMBASE (1974–2014), China National Knowledge Infrastructure (CNKI, 1994–2014), and the Wanfang Database, using the key words “polymorphism,” “CTR,” “osteoporosis,” and “bone density.” The data were extracted independently by two reviewers. The heterogeneity between studies was determined using the Chi-square-based Q test. Potential publication bias was estimated using a funnel plot and Egger’s linear regression test. Odds ratios and 95 % confidence intervals (CI) were used to evaluate the results.

Results

Six eligible studies were selected for the meta-analysis. Our analysis suggested that the C1377T polymorphism of the CTR gene was associated with BMD at the lumbar spine (95 % CI −0.57 to −0.05; P = 0.02), but not associated with BMD at the femoral neck (95 % CI −0.27 to 0.24; P = 0.90) in the postmenopausal Han Chinese population.

Conclusion

The C1377T polymorphism in the CTR gene is associated with BMD at the lumbar spine in a postmenopausal Han Chinese population and the CTR gene may become a useful genetic marker for predicting the risk of developing osteoporosis in postmenopausal Chinese women.

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Acknowledgments

We gratefully thank Zhao Yue and Gilmour Tim for their assistance in preparing the manuscript. Grant sponsor: a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions. This work was funded by Jiangsu Province Foundation for Women’s Health (F201201), and the Jiangsu Women and Children Health Hospital (FXK201201).

Conflict of interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China

    Hongxiu Zhang, Xincheng Tao & Jie Wu

  2. State Key Laboratory of Reproductive Medicine, Department of Obstetrics and Gynecology, First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, 210029, China

    Jie Wu

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  1. Hongxiu Zhang
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Correspondence to Hongxiu Zhang or Jie Wu.

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Zhang, H., Tao, X. & Wu, J. Association of calcitonin receptor gene polymorphism with bone mineral density in postmenopausal Chinese women: a meta-analysis. Arch Gynecol Obstet 291, 165–172 (2015). https://doi.org/10.1007/s00404-014-3378-2

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  • DOI: https://doi.org/10.1007/s00404-014-3378-2

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