Abstract
Objective
This study was to evaluate whether chronic HBV (Hepatitis B virus) infection in women is associated with poor performance following IVF/ICSI (in vitro fertilization/intracytoplasmic sperm injection) treatments.
Materials and methods
123 cycles with female chronic HBV infection were compared with 246 cycles with no-infected couples, matched for female age, D3 serum FSH (follicles stimulation hormone) levels, body mass index and assisted reproductive technology approach used (IVF or ICSI), in a ratio of 1:2.
Results
The details in IVF/ICSI cycles, including the dosage of gonadotrophin used, the serum estradiol levels and the endometrial thickness on the day of hCG (human chorionic gonadotrophin) injection, the mean number of oocytes retrieved, and the embryology data, were similar among seropositive and seronegative women. And there was no significant differences in implantation rates and live birth rates between seropositive women group and matched control (30.52 versus 28.34 % per transfer; 42.28 versus 40.65 %).
Conclusions
The results indicated that women with chronic HBV infection is not associated with outcomes of IVF/ICSI treatments.
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References
Lee VCY, Ng EHY, Yeung WSB, Ho PC (2010) Impact of positive Hepatitis B surface antigen on the outcome of IVF treatment. Reprod BioMed Online 21:712–717
Oger P, Yazbeck C, Gervais A, Dorphin B, Gout C, Jacquesson L et al (2011) Adverse effects of Hepatitis B virus on sperm motility and fertilization ability during IVF. Reprod BioMed Online 23:207–212
Zhou XP, Hu XL, Zhu YM, Qu F, Sun SJ, Qian YL (2011) Comparison of semen quality and outcome of assisted reproductive techniques in Chinese men with and without Hepatitis B. Asian J Androl 13:465–469
Huang JM, Huang TH, Qiu HY, Fang XW, Zhuang TG, Liu HX et al (2003) Effects of Hepatitis B virus infection on human sperm chromosomes. World J Gastroenterol (WJG) 9:736–740
Huang TH, Zhang QJ, Xie QD, Zeng LP, Zeng XF (2005) Presence and integration of HBV DNA in mouse oocytes. World J Gastroenterol (WJG) 11:2869–2873
Ye F, Yue YF, Li SH, Chen TY, Bai GQ, Liu M et al (2006) Presence of HBsAg, HBcAg, and HBVDNA in ovary and ovum of the patients with chronic Hepatitis B virus infection. Am J Obstet Gynecol 194:387–392
Hu XL, Zhou XP, Qian YL, Wu GY, Ye YH, Zhu YM (2011) The presence and expression of the Hepatitis B virus in human oocytes and embryos. Hum Reprod 26:1860–1867
Nie R, Jin L, Zhang HW, Xu B, Chen W, Zhu GJ (2011) Presence of Hepatitis B virus in oocytes and embryos: a risk of Hepatitis B virus transmission during in vitro fertilization. Fertil Steril 95:1667–1671
Ye F, Jin Y, Kong Y, Shi JZ, Qiu HT, Zhang X et al (2012) The presence of HBV mRNA in the fertilized in vitro embryo of HBV patients confirms vertical transmission of HBV via the ovum. Epidemiol Infect 9:1–5
Bagis H, Arat E, Mercan HO, Akligil DA, Caner M, Turanli ET et al (2006) Stable transmission and expression of the Hepatitis B virus total genome in hybrid transgenic mice until F10 generation. J Exp Zool 305:420–427
Ali BA, Huang TH, Xie QD (2004) Detection and expression of Hepatitis B virus X gene in one and two-cell embryos from golden hamster oocytes in vitro fertilized with human spermatozoa carrying HBV DNA. Mol Reprod Dev 70:30–36
Ali BA, Huang TH, Salem HH, Xie QD (2006) Expression of Hepatitis B virus genes in early embryonic cells originated from hamster ova and human spermatozoa transfected with the complete viral genome. Asian J Androl 8:273–279
Xiong XF, Huang TH, Xie QD, Wang XM, Chen GL (2005) Replication and expression of sperm-mediated HBV DNA in early mouse embryo. Teratog Carcinog Mutagen 17:175–178
Zhou XL, Sun PN, Huang TH, Xie QD, Kang XJ, Liu LM (2009) Effects of Hepatitis B virus S protein on human sperm function. Hum Reprod 24:1575–1583
Marchetti C, Obert G, Defossez A, Formstecher P, Marchetti P (2002) Study of mitochondrial membrane potential, reactive oxygen species, DNA fragmentation and cell viability by flow cytometry in human sperm. Hum Reprod 17:1257–1265
Piasecka M, Kawiak J (2003) Sperm mitochondria of patients with normal sperm motility and with asthenozoospermia: morphological and functional study. Folia Histochem Cytobiol 41:125–139
Kang XJ, Xie QD, Zhou XL, Li FZ, Huang JH, Liu DL et al (2012) Effects of Hepatitis B virus S protein exposure on sperm membrane integrity and functions. PLoS One 7:e33471–e33480
Chen LZ, Fan XG, Gao JM (2005) Detection of HBsAg, HBcAg, and HBV DNA in ovarian tissues from patients with HBV infection. World J Gastroenterol (WJG) 11:5565–5567
Zheng BJ, Ng MH, He LF, Yao X, Chan KW, Yuen KY et al (2001) Therapeutic efficacy of Hepatitis B surface antigen-antibodies recombinant DNA composite in HBsAg transgenic mice. Vaccine 19:4219–4225
Jancar S, Sa′nchez CM (2005) Immune complex-mediated tissue injury: a multistep paradigm. Trends Immunol 26:48–55
Pirwany IR, Phillips S, Kelly S, Buckett W, Tan SL (2004) Reproductive performance of couples discordant for Hepatitis B and C Following IVF treatment. J Assist Reprod Genet 21:157–161
Lam PM, Suen SH, Lao TT, Cheung LP, Leung TY, Haines C (2010) Hepatitis B infection and outcomes of in vitro fertilization and embryo transfer treatment. Fertil Steril 93:480–485
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We would like thank Ghamor-Amegavi Edem Prince for assistance in writings and grammar error correction.
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Chen, H., Ge, HS., Lv, JQ. et al. Chronic hepatitis B virus infection in women is not associated with IVF/ICSI outcomes. Arch Gynecol Obstet 289, 213–217 (2014). https://doi.org/10.1007/s00404-013-2975-9
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DOI: https://doi.org/10.1007/s00404-013-2975-9