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The role of apoptosis in preterm premature rupture of the human fetal membranes

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

The present study was designed to examine apoptotic cell death via the caspase-dependent pathway in human fetal membranes.

Methods

Amniotic membrane samples were collected from three groups of women: group 1, women with preterm premature rupture of fetal membranes (PPROM) after cesarean delivery (n = 10), group 2, women with preterm labor (PTL) with intact membranes after cesarean delivery (n = 9) and group 3, women with term labor and vaginal delivery after an uncomplicated pregnancy (controls) (n = 11).

Results

Active caspase-3 immunopositivity (ACPI) of the PPROM group was significantly higher than that of the control group (p < 0.05). ACPI was higher in the PTL with intact membranes group as compared to the control group; however, it did not reach statistical significance (p > 0.05).

Conclusion

Active caspase-3 positivity is increased in the fetal membranes of those women with PPROM.

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Conflict of interest

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Authors and Affiliations

  1. Perinatology Department, Zekai Tahir Burak Women’s Health Education and Research Hospital, Ankara, Turkey

    Aylin Saglam & Bekir Serdar Unlu

  2. Department of Histology-Embryology, School of Medicine, Ankara University, 06100, Sihhiye, Ankara, Turkey

    Cinar Ozgur

  3. King’s College Hospital, London, UK

    Iris Derwig

  4. Department of Obstetrics and Gynecology, Rize State Hospital, 53000, Rize, Turkey

    Funda Gode

  5. Department of Obstetrics and Gynecology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey

    Tamer Mungan

Authors
  1. Aylin Saglam
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  2. Cinar Ozgur
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  3. Iris Derwig
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  4. Bekir Serdar Unlu
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  5. Funda Gode
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  6. Tamer Mungan
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Corresponding author

Correspondence to Funda Gode.

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Saglam, A., Ozgur, C., Derwig, I. et al. The role of apoptosis in preterm premature rupture of the human fetal membranes. Arch Gynecol Obstet 288, 501–505 (2013). https://doi.org/10.1007/s00404-013-2774-3

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  • DOI: https://doi.org/10.1007/s00404-013-2774-3

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