Abstract
Purpose
To evaluate the correlation between the levels of anti-mullerian hormone and body mass index between obese and non-obese premenopausal women.
Methods
Serum anti-mullerian hormone levels of women younger than 45 years admitted to our reproductive endocrinology clinic for investigation of infertility were examined in this cross-sectional study. Body mass indices were lower than 30 kg/m2 in 222 patients and equal to or higher than 30 kg/m2 in 37 patients. Levels of antimullerian hormone were analyzed in each group. Blood samples obtained from study subjects were assayed for levels of anti-mullerian hormone, follicle-stimulating hormone, luteinizing hormone, estradiol, prolactin and thyroid stimulating hormone.
Results
There was no significant difference in terms of mean age between the two groups. There was no statistically significant difference between these two groups in terms of FSH, LH, estradiol and prolactin levels. Anti-mullerian hormone levels were 3.46 ± 2.79 ng/ml and 3.79 ± 2.93 ng/ml in non-obese and obese participants, respectively. No statistically significant correlation was found between Anti Müllerian Hormone (AMH) levels and BMI levels in either group (P > 0.05).
Conclusions
Body mass index does not have an effect on serum AMH levels in women of reproductive age. Obesity has no association with levels of serum follicle stimulating hormone, luteinizing hormone, estradiol, prolactin and thyroid stimulating hormone. Obesity is unlikely to affect ovarian reserve in the premenopausal age group.
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References
La Marca A, Broekmans FJ, Volpe A, Fauser BC, Macklon N (2009) ESHRE Special Interest Group for Reproductive Endocrinology, AMH round table: anti-müllerian hormone (AMH): what do we still need to know? Hum Reprod 24:2264–2275
Weenen C, Laven JS, Von Bergh AR, Cranfield M, Groome NP, Visser JA, Kramer P, Fauser BC, Themmen AP (2004) Anti-müllerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment. Mol Hum Reprod 10:77–83
Van Rooij IA, Broekmans FJ, te Velde ER, Fauser BC, Bancsi LF, de Jong FH, Themmen AP (2002) Serum anti-Müllerian hormone levels: a novel measure of ovarian reserve. Hum Reprod 17:3065–3071
Visser JA, de Jong FH, Laven JS, Themmen AP (2006) Anti-müllerian hormone: a new marker for ovarian function. Reproduction 131:1–9
Pigny P, Jonard S, Robert Y, Dewailly D (2006) Serum anti-müllerian hormone as a surrogate for antral follicle count for definition of the polycystic ovary syndrome. J Clin Endocrinol Metab 91:941–945
Seifer DB, Mac Laughlin DT, Christian BP, Feng B, Shelden RM (2002) Early follicular serum müllerian-inhibiting substance levels are associated with ovarian response during assisted reproductive technology cycles. Fertil Steril 77:468–471
Sahmay S, Cetin M, Ocal P, Kaleli S, Senol H, Birol F, Irez T (2011) Serum anti-Müllerian hormone level as predictor of poor ovarian response in IVF patients. Reprod Med Biol 10:113–120
De Vet A, Laven JS, de Jong FH, Themmen AP, Fauser BC (2002) Anti-müllerian hormone serum levels: a putative marker for ovarian aging. Fertil Steril 77:357–362
Bath LE, Wallace WH, Shaw MP, Fitzpatrick C, Anderson RA (2003) Depletion of ovarian reserve in young women after treatment for cancer in childhood. Detection by anti-müllerian hormone, inhibin B and ovarian ultrasound. Hum Reprod 18:2368–2374
La Marca A, Sighinolfi G, Radi D, Argento C, Baraldi E, Artenisio AC et al (2010) Anti-Mullerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART). Hum Reprod Update 16:113–130
Erel CT, Senturk LM (2009) The impact of body mass index on assisted reproduction. Curr Opin Obstet Gynecol 21(3):228–235
Norman RJ, Chura LR, Robker RL (2008) Effects of obesity on assisted reproductive technology outcomes. Fertil Steril 89:1611–1612
Usta T, Oral E (2012) Is the measurement of anti-Müllerian hormone essential? Curr Opin Obstet Gynecol (Epub ahead of print)
Freeman EW, Gracia CR, Sammel MD, Lin H, Chong-Leong L, Strauss JF (2007) Association of anti-mullerian hormone levels with obesity in late reproductive-age women. Fertil Steril 87:101–106
Georgopoulos NA, Saltamavros AD, Decavalas G (2010) Serum AMH, FSH, and LH levels in PCOS. Fertil Steril 93(3):e13
Nardo LG, Christodoulou D, Gould D, Roberts SA, Fitzgerald CT, Laing I (2007) Anti-mullerian hormone levels and antral follicle count in women enrolled in in vitro fertilization cycles: relationship to lifestyle factors, chronological age and reproductive history. Gynecol Endocrinol 23(8):486–493
Wunder DM, Bersinger NA, Yared M, Kretschmer R, Birkhauser MH (2008) Statistically significant changes of antimüllerian hormone and inhibin levels during the physiologic menstrual cycle in reproductive age women. Fertil Steril 89:927–933
Park AS, Lawson MA, Chuan SS, Oberfield SE, Hoeger KM, Witchel SF, Chang RJ (2010) Serum anti-müllerian hormone concentrations are elevated in oligomenorrheic girls without evidence of hyperandrogenism. J Clin Endocrinol Metab 95(4):1786–1792
Zain MM, Norman RJ (2008) Impact of obesity on female fertility and fertility treatment. Womens Health 4(2):183–194
Nelson SM, Fleming RF (2007) The preconceptual contraception paradigm: obesity and infertility. Hum Reprod 22(4):912–915
Prentice A (2006) The emerging epidemic of obesity in developing countries. Int J Epidemiol 35:93–99
Schneider JG, Tompkins C, Blumenthal RS, Mora S (2006) The metabolic syndrome in women. Cardiol Rev 14:286–291
Steiner AZ, Stanczyk FZ, Patel S, Edelman A (2010) Antimüllerian hormone and obesity: insights in oral contraceptive users. Contraception 81(3):245–248
Halawaty S, El Kattan E, Azab H, El Ghamry N, Al-Inany H (2010) Effect of obesity on parameters of ovarian reserve in premenopausal women. J Obstet Gynaecol Can 32(7):687–690
Thomson RL, Buckley JD, Moran LJ, Noakes M, Clifton PM, Norman RJ, Brinkworth GD (2009) The effect of weight loss on anti-müllerian hormone levels in overweight and obese women with polycystic ovary syndrome and reproductive impairment. Hum Reprod 24(8):1976–1981
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Sahmay, S., Usta, T., Erel, C.T. et al. Is there any correlation between amh and obesity in premenopausal women?. Arch Gynecol Obstet 286, 661–665 (2012). https://doi.org/10.1007/s00404-012-2363-x
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DOI: https://doi.org/10.1007/s00404-012-2363-x