Skip to main content
SpringerLink
Log in

Ovarian reserve and in vitro fertilization cycles outcome according to women smoking status and stimulation regimen

  • Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

Smoking is known to be deleterious on female fertility and in vitro fertilization (IVF) outcome, probably partly through ovarian reserve alteration. Recently, anti-Müllerian hormone (AMH) and antral follicle count (AFC) have been shown to be the most accurate ovarian reserve markers. Here, we compared ovarian reserve markers in women undergoing IVF according to smoking status and stimulation regimen.

Methods

AFC, AMH, basal FSH, LH and estradiol, and IVF outcome were compared in 277 women undergoing IVF. Smoking status and ovarian stimulation protocol (i.e. agonists or antagonists) were recorded.

Results

Active smoking women had lower AMH and modified follicles’ size repartition in AFC compared to non-smokers. They also experienced poorer IVF outcome with decreased ovarian response and lower pregnancy rate. This remained true in both antagonist and agonist stimulation protocol groups.

Conclusion

Active smoking in infertile women is associated with ovarian reserve alteration, as reflected by AFC modification and decreased serum AMH, and leads to poor prognosis in ART cycles, whatever the stimulation protocol used. Infertile women should be strongly discouraged from smoking before they start IVF cycles.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Broer SL, Mol BW, Hendriks D, Broekmans FJ (2009) The role of antimullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count. Fertil Steril 91:705–714

    Article  PubMed  CAS  Google Scholar 

  2. Broer SL, Dólleman M, Opmeer BC, Fauser BC, Mol BW, Broekmans FJ (2011) AMH and AFC as predictors of excessive response in controlled ovarian hyperstimulation: a meta-analysis. Hum Reprod Update 17:46–54

    Article  PubMed  CAS  Google Scholar 

  3. Broekmans FJ, de Ziegler D, Howles CM, Gougeon A, Trew G, Olivennes F (2010) The antral follicle count: practical recommendations for better standardization. Fertil Steril 94:1044–1051

    Article  PubMed  Google Scholar 

  4. Grynberg M, Genro V, Gallot V, El-Ali A, Frydman R, Fanchin R (2010) Early follicle development during the luteal-follicular transition affects the predictability of serum follicle-stimulating hormone but not antimüllerian hormone levels on cycle day 3. Fertil Steril 94:1827–1831

    Article  PubMed  CAS  Google Scholar 

  5. Waylen AL, Metwally M, Jones GL, Wilkinson AJ, Ledger WL (2009) Effects of cigarette smoking upon clinical outcomes of assisted reproduction: a meta-analysis. Hum Reprod Update 15:31–44

    Article  PubMed  CAS  Google Scholar 

  6. Freour T, Dessolle L, Jean M, Masson D, Barriere P (2010) Predictive value of ovarian reserve markers in smoking and non-smoking women undergoing IVF. Reprod Biomed Online 20:857–860

    Article  PubMed  Google Scholar 

  7. Lambert-Messerlian GM, Harlow BL (2006) The influence of depression, body mass index, and smoking on serum inhibin B levels in late reproductive-aged women. J Clin Endocrinol Metab 91:1496–1500

    Article  PubMed  CAS  Google Scholar 

  8. Kinney A, Kline J, Kelly A, Reuss ML, Levin B (2007) Smoking, alcohol and caffeine in relation to ovarian age during the reproductive years. Hum Reprod 22:1175–1185

    Article  PubMed  CAS  Google Scholar 

  9. Freour T, Masson D, Mirallie S et al (2008) Active smoking compromises IVF outcome and affects ovarian reserve. Reprod Biomed Online 16:96–102

    Article  PubMed  Google Scholar 

  10. Jick H, Porter J (1977) Relation between smoking and age of natural menopause. Report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center. Lancet 1:1354–1355

    Article  PubMed  CAS  Google Scholar 

  11. Mikkelsen TF, Graff-Iversen S, Sundby J, Bjertness E (2007) Early menopause, association with tobacco smoking, coffee consumption and other lifestyle factors: a cross-sectional study. BMC Public Health 7:149

    Article  PubMed  Google Scholar 

  12. Tuttle AM, Stämpfli M, Foster WG (2009) Cigarette smoke causes follicle loss in mice ovaries at concentrations representative of human exposure. Hum Reprod 24:1452–1459

    Article  PubMed  CAS  Google Scholar 

  13. Jurisicova A, Taniuchi A, Li H et al (2007) Maternal exposure to polycyclic aromatic hydrocarbons diminishes murine ovarian reserve via induction of Harakiri. J Clin Invest 117:3971–3978

    PubMed  CAS  Google Scholar 

  14. Fanchin R, Schonäuer LM, Righini C, Guibourdenche J, Frydman R, Taieb J (2003) Serum anti-Müllerian hormone is more strongly related to ovarian follicular status than serum inhibin B, estradiol, FSH and LH on day 3. Hum Reprod 18:323–327

    Article  PubMed  CAS  Google Scholar 

  15. Chang MY, Chiang CH, Hsieh TT, Soong YK, Hsu KH (1998) Use of the antral follicle count to predict the outcome of assisted reproductive technologies. Fertil Steril 69:505–510

    Article  PubMed  CAS  Google Scholar 

  16. Hendriks DJ, Kwee J, Mol BW, te Velde ER, Broekmans FJ (2007) Ultrasonography as a tool for the prediction of outcome in IVF patients: a comparative meta-analysis of ovarian volume and antral follicle count. Fertil Steril 87:764–775

    Article  PubMed  Google Scholar 

  17. Mattison DR, Singh H, Takizawa K, Thomford PJ (1989) Ovarian toxicity of benzo(a)pyrene and metabolites in mice. Reprod Toxicol 3:115–125

    Article  PubMed  CAS  Google Scholar 

  18. Shiromizu K, Mattison DR (1984) The effect of intraovarian injection of benzo(a)pyrene on primordial oocyte number and ovarian aryl hydrocarbon [benzo(a)pyrene] hydroxylase activity. Toxicol Appl Pharmacol 76:18–25

    Article  PubMed  CAS  Google Scholar 

  19. Lienesch LA, Dumont JN, Bantle JA (2000) The effect of cadmium on oogenesis in Xenopus laevis. Chemosphere 41:1651–1658

    Article  PubMed  CAS  Google Scholar 

  20. Jayaprakasan K, Hilwah N, Kendall NR et al (2007) Does 3D ultrasound offer any advantage in the pretreatment assessment of ovarian reserve and prediction of outcome after assisted reproduction treatment? Hum Reprod 22:1932–1941

    Article  PubMed  CAS  Google Scholar 

  21. Haadsma ML, Bukman A, Groen H, Roeloffzen EM, Groenewoud ER, Heineman MJ, Hoek A (2007) The number of small antral follicles (2–6 mm) determines the outcome of endocrine ovarian reserve tests in a subfertile population. Hum Reprod 22:1925–1931

    Article  PubMed  CAS  Google Scholar 

  22. Santos MA, Kuijk EW, Macklon NS (2010) The impact of ovarian stimulation for IVF on the developing embryo. Reproduction 139:23–34

    Article  PubMed  CAS  Google Scholar 

  23. Al-Inany HG, Abou-Setta AM, Aboulghar M (2007) Gonadotrophin-releasing hormone antagonists for assisted conception: a Cochrane review. Reprod Biomed Online 14:640–649

    Article  PubMed  CAS  Google Scholar 

  24. Practice Committee of American Society for Reproductive Medicine (2008) Smoking and infertility. Fertil Steril 90(5 Suppl):S254–S259

    Google Scholar 

  25. Barbieri RL (2001) The initial fertility consultation: recommendations concerning cigarette smoking, body mass index, and alcohol and caffeine consumption. Am J Obstet Gynecol 185:1168–1173

    Article  PubMed  CAS  Google Scholar 

  26. Triopon G, Tailland ML, Faillie JL et al (2006) In vitro fertilization and smoking: use of urinary cotinine and expired air carbon monoxide measurements. Gynecol Obstet Fertil 34:1043–1050

    Article  PubMed  CAS  Google Scholar 

  27. Neal MS, Hughes EG et al (2005) Sidestream smoking is equally as damaging as mainstream smoking on IVF outcomes. Hum Reprod 20:2531–2535

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

All the authors declare they have nothing to disclose.

Author information

Authors and Affiliations

  1. Reproductive Medicine Unit, University Hospital of Nantes, Nantes, France

    Thomas Freour, Lionel Dessolle, Dalila Allaoua, Sophie Mirallie, Miguel Jean & Paul Barriere

  2. Hormonology and Biochemistry Laboratory, University Hospital of Nantes, Nantes, France

    Damien Masson & Thomas Dejoie

  3. Service de Médecine de la Reproduction et Biologie du développement, Hôpital Mère et Enfant, CHU de Nantes, 38 boulevard Jean Monnet, 44093, Nantes Cedex, France

    Thomas Freour

Authors
  1. Thomas Freour
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Damien Masson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lionel Dessolle
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Dalila Allaoua
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Thomas Dejoie
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Sophie Mirallie
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Miguel Jean
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Paul Barriere
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Thomas Freour.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Freour, T., Masson, D., Dessolle, L. et al. Ovarian reserve and in vitro fertilization cycles outcome according to women smoking status and stimulation regimen. Arch Gynecol Obstet 285, 1177–1182 (2012). https://doi.org/10.1007/s00404-011-2172-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-011-2172-7

Keywords

Search

Navigation