Skip to main content

Advertisement

SpringerLink
Log in

Diagnosis and treatment options of vulvar cancer: a review

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Introduction

Vulvar cancer is a rare malignancy in women. However, within the past decade, a distinct increase in the incidence of vulvar intraepithelial neoplasia (VIN) as a precursor lesion, and an increase of vulvar cancer have been reported within Europe and the USA. Surgery is the first choice in treating patients with vulvar cancer, especially in its early stages. In an attempt to decrease the incidence of complications, research was made into modifications of the surgical procedure without compromising the prognosis. The replacement of radical vulvectomy by less wide local excision is one of these modifications. As vulvar cancer is relatively rare, it is possible to give evidence-based treatment recommendations, but usually on a low evidence level. Aim of this paper is to elucidate diagnostics and surgical treatment options in the management of vulvar cancer.

Materials and methods

We searched major databases (i.e. pubmed) with the following selection criteria: vulvar cancer, en bloc resection, triple incision, and sentinel node biopsy.

Conclusions

Today, the operative therapy is much less radical and more emphasized on individualized therapeutic concepts. The tendency is to leave the ultraradical surgical options which suffer from high morbidity towards less radical, minimal invasive techniques. Due to the rarity of the disease further studies will have to be performed by international collaborative groups.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. American Cancer Society (2010) Cancer Facts & Figures 2010

  2. Hampl M, Deckers-Figiel S, Hampl JA, Rein D, Bender HG (2008) New aspects of vulvar cancer: changes in localization and age of onset. Gynecol Oncol 109(3):340–345

    Article  PubMed  Google Scholar 

  3. Judson PL, Habermann EB, Baxter NN, Durham SB, Virnig BA (2006) Trends in the incidence of invasive and in situ vulvar cancer. Am J Obstet Gynecol 107:1018–1022

    Article  Google Scholar 

  4. Maclean AB (2006) Vulvar cancer: prevention and screening. Best Pract Res Clin Obstet Gynaecol 20(2):379–395

    Article  PubMed  Google Scholar 

  5. Hampl M, Sarajuuri H, Wentzensen N, Bender HG, Küppers V (2006) Effect of human papillomavirus vaccines on vulvar, vaginal and anal intraepithelial lesions and vulvar cancer. Obstet Gynecol 108:1361–1368

    Article  PubMed  CAS  Google Scholar 

  6. De Vuyst H, Clifford GM, Nascimento MC, Madeleine MM, Franceschi S (2009) Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis. Int J Cancer 124(7):1626–1636

    Article  PubMed  Google Scholar 

  7. Van Beurden M, ten Kate FW, Tjong-A-Hung SP, de Craen AJ, van der Vange N, Lammes FB, ter Schegget J (1998) Human papillomavirus DNA in multicentric vulvar intraepithelial neoplasia. Int J Gynecol Pathol 17:12–16

    Article  PubMed  Google Scholar 

  8. Rolfe KJ, MacLean AB, Crow JC, Benjamin E, Reid WM, Perrett CW (2003) TP53 mutations in vulval lichen sclerosus adjacent to squamous cell carcinoma of the vulva. Br J Cancer 89(12):2249–2253

    Article  PubMed  CAS  Google Scholar 

  9. Micci F, Teixeira MR, Scheistrøen M, Abeler VM, Heim S (2003) Cytogenetic characterization of tumors of the vulva and vagina. Genes Chromosomes Cancer 38(2):137–148

    Article  PubMed  Google Scholar 

  10. Kunjoonju JP, Raitanen M, Grénman S, Tiwari N, Worsham MJ (2005) Identification of individual genes altered in squamous cell carcinoma of the vulva. Genes Chromosomes Cancer 44(2):185–193

    Article  PubMed  CAS  Google Scholar 

  11. van der Avoort IA, Shirango H, Hoevenaars BM, Grefte JM, de Hullu JA, de Wilde PC, Bulten J, Melchers WJ, Massuger LF (2006) Vulvar squamous cell carcinoma is a multifactorial disease following two separate and independent pathways. Int J Gynecol Pathol 25(1):22–29

    Article  PubMed  Google Scholar 

  12. van de Nieuwenhof HP, van der Avoort IA, de Hullu JA (2008) Review of squamous premalignant vulvar lesions. Crit Rev Oncol Hematol 68(2):131–156

    Article  PubMed  Google Scholar 

  13. Jones RW, Joura EA (1999) Analyzing prior clinical events at presentation in 102 women with vulvar carcinoma: Evidence of diagnostic delays. J Reprod Med 44:766–768

    PubMed  CAS  Google Scholar 

  14. Nauth HF (1986) Vulva-Zytologie. Makroskopie, Histologie und Zytologie der normalen und erkrankten Vulva. Lehrbuch und Atlas. Thieme, Stuttgart

    Google Scholar 

  15. Hacker NF (2005) Vulvar cancer. In: Berek JS, Hacker NF (eds) Practical gynaecologic oncology, 3rd edn edn. Williams & Wilkins, Baltimore

    Google Scholar 

  16. Sobin LH, Gospodarowicz MK, Wittekind Ch (2009) UICC: TNM classification of malignant tumors, 7th edn. Wiley-Blackwell, Oxford, ISBN 978-1-4443-3241-4

  17. Hölzel D, Klamert A, Schmidt M (1996) Krebs: Häufigkeiten, Befunde und Behandlungsergebnisse. Perspektiven für die Krebsdiskussion und eine quantitative klinisch-epidemiologische Onkologie aus dem Tumorregister München. Zuckschwerdt, München

    Google Scholar 

  18. Kürzl R, Messerer D (1989) Prognostic factors in squamous cell carcinoma of the vulva: a multivariate analysis. Gynecol Oncol 32:143–150

    Article  PubMed  Google Scholar 

  19. Smyczek-Gargya B, Volz B, Geppert M, Dietl J (1997) A multivariate analysis of clinical and morphological prognostic factors in squamous cell carcinoma of the vulva. Gynecol Obstet Invest 43(4):261–267

    Article  PubMed  CAS  Google Scholar 

  20. Schnürch HG (2000) Therapie des Vulva- und Vaginalkarzinoms. Onkologe 6:1046–1060

    Article  Google Scholar 

  21. Landrum LM, Lanneau GS, Skaggs VJ, Gould N, Walker JL, McMeekin DS, Gold MA (2007) Gynecologic oncology group risk groups for vulvar carcinoma: improvement in survival in the modern era. Gynecol Oncol 106(3):521–525

    Article  PubMed  Google Scholar 

  22. Schnürch HG, Hantschmann P (2008) Vulvakarzinom. Der Gynäkologe 41:215–227

    Article  Google Scholar 

  23. Ambros RA, Malfetano JH, Mihm MC Jr (1996) Clinicopathologic features of vulvar squamous cell carcinomas exhibiting prominent fibromyxoid stromal response. Int J Gynecol Pathol 15:137–145

    Article  PubMed  CAS  Google Scholar 

  24. Bancher-Todesca D, Obermair A, Bilgi S, Kohlberger P, Kainz C, Breitenecker G, Leodolter S, Gitsch G (1997) Angiogenesis in vulvar intraepithelial neoplasia. Gynecol Oncol 64:496–500

    Article  PubMed  CAS  Google Scholar 

  25. Blecharz P, Karolewski K, Bieda T, Klimek M, Pudelek J, Kojs E, Zur K, Dzilak P, Urbanski K (2008) Prognostic factors in patients with carcinoma of the vulva–our own experience and literature review. Eur J Gynecol Oncol 29(3):260–263

    CAS  Google Scholar 

  26. Gotlieb WH (2003) The assessment and surgical management of early-stage vulvar cancer. Best Pract Res Clin Obstet Gynaecol 17:557–569

    Article  PubMed  Google Scholar 

  27. Grimshaw RN, Murdoch JB, Monghan JM (1993) Radical vulvectomy and bilateral inguinal, femoral lymphadenectomy separate incisions—experience with 100 cases. Int J Gynecol Cancer 2:18–23

    Article  Google Scholar 

  28. Helm CW, Hatch K, Austin JM, Partridge EE, Soong SJ, Elder JE, Shingleton HM (1992) A matched comparison of single and triple incision techniques for the surgical treatment of carcinoma of the vulva. Gynecol Oncol 46(2):150–156

    Article  PubMed  CAS  Google Scholar 

  29. Hopkins MP, Reid GC, Morley GW (1993) Radical vulvectomy. The decision for the incision. Cancer 72(3):799–803

    Article  PubMed  CAS  Google Scholar 

  30. Ansink A, van der Velden J (2002) Surgical interventions for early squamous cell carcinoma of the vulva (Cochrane Review). Cochrane library, issue 1. Update Software, Oxford

  31. De Hullu JA, Hollema H, Lolkema S, Boezen M, Boonstra H, Burger MP, Aalders JG, Mourits MJ, Van Der Zee AG (2002) Vulvar carcinoma. The price of less radical surgery. Cancer 95(11):2331–2338

    Article  PubMed  Google Scholar 

  32. De Hullu JA, van der Zee AG (2006) Surgery and radiotherapy in vulvar cancer. Crit Rev Oncol Hematol 60(1):38–58

    Article  PubMed  Google Scholar 

  33. Stehman FB, Look KY (2006) Carcinoma of the vulva. Obstet Gynecol 107(3):719–733

    Article  PubMed  Google Scholar 

  34. Burke TW, Stringer CA, Gershenson DM, Edwards CL, Morris M, Wharton JT (1990) Radical wide excision and selective inguinal node dissection for squamous cell carcinoma of the vulva. Gynecol Oncol 38(3):328–332

    Article  PubMed  CAS  Google Scholar 

  35. Burke TW, Levenback C, Coleman RL, Morris M, Silva EG, Gershenson DM (1995) Surgical therapy of T1 and T2 vulvar carcinoma: further experience with radical wide excision and selective inguinal lymphadenectomy. Gynecol Oncol 57:215–220

    Article  PubMed  CAS  Google Scholar 

  36. Höckel M, Dornhöfer N (2008) Vulvovaginal reconstruction for neoplastic disease. Lancet Oncol 9(6):559–568

    Article  PubMed  Google Scholar 

  37. Weikel W, Schmidt M, Steiner E, Knapstein PG, Koelbl H (2006) Surgical therapy of recurrent vulvar cancer. Am J Obstet Gynecol 195(5):1293–1302

    Article  PubMed  Google Scholar 

  38. van Doorn HC, Ansink A, Verhaar-Langereis M, Stalpers L (2006) Neoadjuvant chemoradiation for advanced primary vulvar cancer. Cochrane Database Syst Rev 3:CD003752

    PubMed  Google Scholar 

  39. Tans L, Ansink AC, van Rooij PH, Kleijnen C, Mens JW (2011) The role of chemo-radiotherapy in the management of locally advanced carcinoma of the vulva: single institutional experience and review of literature. Am J Clin Oncol 34(1):22–26

    Article  PubMed  Google Scholar 

  40. Seeger AR, Windschall A, Lotter M, Mehlhorn G, Beckmann MW, Sauer R, Strnad V (2006) The role of interstitial brachytherapy in the treatment of vaginal and vulvar malignancies. Strahlenther Onkol 182(3):142–148

    Article  PubMed  Google Scholar 

  41. Wilkinson EJ, Rico MJ, Pierson KK (1982) Microinvasive carcinoma of the vulva. Int J Gynecol Pathol 1:29–35

    Article  PubMed  CAS  Google Scholar 

  42. Van der Velden J, Ansink A (2001) Primary groin irradiation vs primary groin surgery for early vulvar cancer. Cochrane Database Syst Rev (4):CD002224 (Review)

  43. Stehman FB, Bundy BN, Dvoretsky PM, Creasman WT (1992) Early stage I carcinoma of the vulva treated with ipsilateral superficial inguinal lymphadenectomy and modified radical hemivulvectomy: a prospective study of the Gynaecologic Oncology Group. Obstet Gynecol 79:490–497

    PubMed  CAS  Google Scholar 

  44. Burger MPM, Hollema H, Bouma J (1996) The side of groin node metastases in unilateral vulvar carcinoma. Int J Gynecol Cancer 6:318–322

    Article  Google Scholar 

  45. Blake P (2003) Radiotherapy and chemoradiotherapy for carcinoma of the vulva. Best Pract Res Clin Obstet Gynaecol 17:649–661

    Article  PubMed  Google Scholar 

  46. Origoni M, Ssideri M, Garsia S, Carinelli SG, Ferrari AG (1992) Prognostic value of pathological patterns of lymph node positivity in squamous cell carcinoma of the vulva stage III and IVA FIGO. Gynecol Oncol 45:313–316

    Article  PubMed  CAS  Google Scholar 

  47. Homesly HD, Bundi BN, Sedlis A, Adcock L (1986) Radiation therapy versus pelvic node resection for carcinoma of the vulva with positive groin nodes. Obstet Gynecol 68:733–740

    Google Scholar 

  48. Kunos C, Simpkins F, Gibbons H, Tian C, Homesley H (2009) Radiation therapy compared with pelvic node resection for node-positive vulvar cancer: a randomized controlled trial. Obstet Gynecol 114(3):537–546

    Article  PubMed  Google Scholar 

  49. Levenback C, Burke TW, Morris M, Malpica A, Lucas KR, Gershenson DM (1995) Potential applications of intraoperative lymphatic mapping in vulvar cancer. Gynecol Oncol 59(2):216–220

    Article  PubMed  CAS  Google Scholar 

  50. Decesare SL, Fiorica JV, Roberts WS, Reintgen D, Arango H, Hoffman MS, Puleo C, Cavanagh D (1997) A pilot study utilizing intraoperative lymphoscintigraphy for identification of the sentinel lymph nodes in vulvar cancer. Gynecol Oncol 66(3):425–428

    Article  PubMed  CAS  Google Scholar 

  51. De Cicco C, Sideri M, Bartolomei M et al (1997) Sentinel node detection by lymphoscintigraphy and gamma detecting probe in patients with vulvar cancer (abstract). J Nucl Med 38:33P

    Google Scholar 

  52. de Hullu JA, Doting E, Piers DA, Hollema H, Aalders JG, Koops HS, Boonstra H, van der Zee AG (1998) Sentinel lymph node identification with technetium-99m-labeled nanocolloid in squamous cell cancer of the vulva. J Nucl Med 39(8):1381–1385

    PubMed  Google Scholar 

  53. Ansink AC, Sie-Go DM, van der Velden J, Sijmons EA, de Barros Lopes A, Monaghan JM, Kenter GG, Murdoch JB, ten Kate FJ, Heintz AP (1999) Identification of sentinel lymph nodes in vulvar carcinoma patients with the aid of a patent blue V injection: a multicenter study. Cancer 86(4):652–656

    Article  PubMed  CAS  Google Scholar 

  54. Tavares MG, Sapienza MT, Galeb NA Jr, Belfort FA, Costa RR, Osório CA, Góes JC, Endo IS, Soares J Jr, Lewin S, Marone MM (2001) The use of 99mTc-phytate for sentinel node mapping in melanoma, breast cancer and vulvar cancer: a study of 100 cases. Eur J Nucl Med 28(11):1597–1604

    Article  PubMed  CAS  Google Scholar 

  55. Molpus KL, Kelley MC, Johnson JE, Martin WH, Jones HW 3rd (2001) Sentinel lymph node detection and microstaging in vulvar carcinoma. J Reprod Med 46(10):863–869

    PubMed  CAS  Google Scholar 

  56. Makar AP, Scheistroen M, van den Weyngaert D, Tropé CG (2001) Surgical management of stage I and II vulvar cancer: the role of the sentinel node biopsy. Review of literature. Int J Gynecol Cancer 11(4):255–262

    Article  PubMed  CAS  Google Scholar 

  57. De Cicco C, Sideri M, Bartolomei M, Grana C, Cremonesi M, Fiorenza M, Maggioni A, Bocciolone L, Mangioni C, Colombo N, Paganelli G (2000) Sentinel node biopsy in early vulvar cancer. Br J Cancer 82(2):295–299

    Article  PubMed  Google Scholar 

  58. de Hullu JA, Hollema H, Piers DA, Verheijen RH, van Diest PJ, Mourits MJ, Aalders JG, van Der Zee AG (2000) Sentinel lymph node procedure is highly accurate in squamous cell carcinoma of the vulva. J Clin Oncol 18(15):2811–2816

    PubMed  Google Scholar 

  59. Levenback C, Coleman RL, Burke TW, Bodurka-Bevers D, Wolf JK, Gershenson DM (2001) Intraoperative lymphatic mapping and sentinel node identification with blue dye in patients with vulvar cancer. Gynecol Oncol 83(2):276–281

    Article  PubMed  CAS  Google Scholar 

  60. Sliutz G, Reinthaller A, Lantzsch T, Mende T, Sinzinger H, Kainz C, Koelbl H (2002) Lymphatic mapping of sentinel nodes in early vulvar cancer. Gynecol Oncol 84(3):449–452

    Article  PubMed  CAS  Google Scholar 

  61. Moore RG, DePasquale SE, Steinhoff MM, Gajewski W, Steller M, Noto R, Falkenberry S (2003) Sentinel node identification and the ability to detect metastatic tumor to inguinal lymph nodes in squamous cell cancer of the vulva. Gynecol Oncol 89(3):475–479

    Article  PubMed  Google Scholar 

  62. Puig-Tintoré LM, Ordi J, Vidal-Sicart S, Lejárcegui JA, Torné A, Pahisa J, Iglesias X (2003) Further data on the usefulness of sentinel lymph node identification and ultrastaging in vulvar squamous cell carcinoma. Gynecol Oncol 88(1):29–34

    Article  PubMed  Google Scholar 

  63. Louis-Sylvestre C, Evangelista E, Leonard F, Itti E, Meignan M, Paniel BJ (2005) Sentinel node localization should be interpreted with caution in midline vulvar cancer. Gynecol Oncol 97(1):151–154

    Article  PubMed  Google Scholar 

  64. Merisio C, Berretta R, Gualdi M, Pultrone DC, Anfuso S, Agnese G, Aprile C, Mereu L, Salamano S, Tateo S, Melpignano M (2005) Radioguided sentinel lymph node detection in vulvar cancer. Int J Gynecol Cancer. 15(3):493–497

    Article  PubMed  CAS  Google Scholar 

  65. Rob L, Robova H, Pluta M, Strnad P, Kacirek J, Skapa P, Taborska K (2007) Further data on sentinel lymph node mapping in vulvar cancer by blue dye and radiocolloid Tc99. Int J Gynecol Cancer 17(1):147–153

    Article  PubMed  Google Scholar 

  66. Hauspy J, Beiner M, Harley I, Ehrlich L, Rasty G, Covens A (2007) Sentinel lymph node in vulvar cancer. Cancer 110(5):1015–1023

    Article  PubMed  Google Scholar 

  67. Moore RG, Robison K, Brown AK, DiSilvestro P, Steinhoff M, Noto R, Brard L, Granai CO (2008) Isolated sentinel lymph node dissection with conservative management in patients with squamous cell carcinoma of the vulva: a prospective trial. Gynecol Oncol 109(1):65–70

    Article  PubMed  Google Scholar 

  68. Van der Zee AG, Oonk MH, De Hullu JA, Ansink AC, Vergote I, Verheijen RH, Maggioni A, Gaarenstroom KN, Baldwin PJ, Van Dorst EB, Van der Velden J, Hermans RH, van der Putten H, Drouin P, Schneider A, Sluiter WJ (2008) Sentinel node dissection is safe in the treatment of early-stage vulvar cancer. J Clin Oncol 26(6):884–889

    Article  PubMed  Google Scholar 

  69. Levenback CF et al (2009) Sentinel node (SN) biopsy in patients with vulvar cancer: a Gynecologic Oncology Group (GOG) study. J Clin Oncol 27:15s (suppl; abstr 5505)

    Article  Google Scholar 

  70. Lindell G, Jonsson C, Ehrsson RJ, Jacobsson H, Danielsson KG, Källström BN, Larson B (2010) Evaluation of preoperative lymphoscintigraphy and sentinel node procedure in vulvar cancer. Eur J Obstet Gynecol Reprod Biol 152(1):91–95

    Article  PubMed  Google Scholar 

  71. Oonk MH, de Hullu JA, van der Zee AG (2010) Current controversies in the management of patients with early-stage vulvar cancer. Curr Opin Oncol S22(5):481–486

    Article  Google Scholar 

  72. Oonk MH, van Hemel BM, Hollema H, de Hullu JA, Ansink AC, Vergote I, Verheijen RH, Maggioni A, Gaarenstroom KN, Baldwin PJ, van Dorst EB, van der Velden J, Hermans RH, van der Putten HW, Drouin P, Runnebaum IB, Sluiter WJ, van der Zee AG (2010) Size of sentinel-node metastasis and chances of non-sentinel-node involvement and survival in early stage vulvar cancer: results from GROINSS-V, a multicentre observational study. Lancet Oncol 11(7):646–652

    Article  PubMed  Google Scholar 

  73. Weikel W, Schmidt M, Steiner E, Knapstein PG, Koelbl H (2008) Reconstructive plastic surgery in the treatment of vulvar carcinomas. Eur J Obstet Gynecol Reprod Biol 136(1):102–109

    Article  PubMed  Google Scholar 

  74. Chan JK, Sugiyama V, Pham H, Gu M, Rutgers J, Osann K, Cheung MK, Berman ML, Disaia PJ (2007) Margin distance and other clinico-pathologic prognostic factors in vulvar carcinoma: a multivariate analysis. Gynecol Oncol 104(3):636–641

    Article  PubMed  Google Scholar 

  75. Faul CM, Mirmow D, Huang Q, Gerszten K, Day R, Jones MW (1997) Adjuvant radiation for vulvar carcinoma: improved local control. Int J Radiat Oncol Biol Phys 38(2):381–389

    Article  PubMed  CAS  Google Scholar 

  76. Bellati F, Angioli R, Manci N, Angelo Zullo M, Muzii L, Plotti F, Basile S, Panici PB (2005) Single agent cisplatin chemotherapy in surgically resected vulvar cancer patients with multiple inguinal lymph node metastases. Gynecol Oncol 96(1):227–231

    Article  PubMed  CAS  Google Scholar 

  77. van Doorn HC, Ansink A, Verhaar-Langereis M, Stalpers L (2006) Neoadjuvant chemoradiation for advanced primary vulvar cancer. Cochrane Database Syst Rev 3:CD003752

    PubMed  Google Scholar 

  78. Moore RG, Robison K, Brown AK, DiSilvestro P, Steinhoff M, Noto R, Brard L, Granai CO (2008) Isolated sentinel lymph node dissection with conservative management in patients with squamous cell carcinoma of the vulva: a prospective trial. Gynecol Oncol 109(1):65–70

    Article  PubMed  Google Scholar 

  79. Cunningham MJ, Goyer RP, Gibbons SK, Kredentser DC, Malfetano JH, Keys H (1997) Primary radiation, cisplatin, and 5-fluorouracil for advanced squamous carcinoma of the vulva. Gynecol Oncol 66(2):258–261

    Article  PubMed  CAS  Google Scholar 

Download references

Conflict of interest

The authors certify that no potential conflict of interest in relation to this article exists.

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, University Hospital of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany

    C. Dittmer, D. Fischer, K. Diedrich & M. Thill

Authors
  1. C. Dittmer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Fischer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. Diedrich
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Thill
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to C. Dittmer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dittmer, C., Fischer, D., Diedrich, K. et al. Diagnosis and treatment options of vulvar cancer: a review. Arch Gynecol Obstet 285, 183–193 (2012). https://doi.org/10.1007/s00404-011-2057-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-011-2057-9

Keywords

Search

Navigation