Abstract
Purpose
Menopausal symptoms are major concerns of postmenopausal women. Metabolic syndrome (MetS) is a risk factor for cardiovascular disease, and menopause is associated with an increased prevalence of MetS. The purpose of this study was to determine the association between menopausal symptoms and MetS in postmenopausal women.
Methods
We selected 183 women who attended St. Vincent Hospital of the Catholic University of Korea in 2008 and 2009 and divided them into two groups (with and without MetS). Menopausal status was assessed with the Menopause Rating Scale (MRS) questionnaire. The body mass index and waist-to-hip ratio were determined, and the serum fasting glucose, lipid profile, and blood pressure were measured in all participants.
Results
Of 183 postmenopausal women, 64 (35.0%) had MetS. A significant increase was observed in the total MRS score and the total somatic symptom subscale score in the MetS group (p = 0.021, p = 0.043, respectively). Vasomotor symptoms such as hot flashes and sweating occurred with higher frequency in the MetS group than in those without MetS (p = 0.034). High triglyceride levels and an increase of the number of components of MetS were associated with a higher total subscale score of somatic symptoms (p = 0.044, p = 0.039, respectively).
Conclusions
These results showed that a higher total subscale score and a higher frequency of somatic symptoms such as hot flashes and sweating were present in the MetS group. Larger scale studies are needed to clarify the association between other menopausal symptoms and MetS in postmenopausal women.
Similar content being viewed by others
References
Hunter M (1992) The south-east England longitudinal study of the climacteric and postmenopause. Maturitas 14:117–126
Schmidt PJ, Rubinow DR (1991) Menopause-related affective disorders: a justification for further study. Am J Psychiatry 148:844–852
Dennerstein L, Randolph J, Taffe J, Dudley E, Burger H (2002) Hormones, mood, sexuality, and the menopausal transition. Fertil Steril 77(Suppl 4):S42–S48
Grodstein F, Stampfer M (1995) The epidemiology of coronary heart disease and estrogen replacement in postmenopausal women. Prog Cardiovasc Dis 38:199–210
Riis BJ, Hansen MA, Jensen AM, Overgaard K, Christiansen C (1996) Low bone mass and fast rate of bone loss at menopause: equal risk factors for future fracture: a 15-year follow-up study. Bone 19:9–12
Burger HG, Dudley EC, Robertson DM, Dennerstein L (2002) Hormonal changes in the menopause transition. Recent Prog Horm Res 57:257–275
Ulrich LG, Barlow DH, Sturdee DW, Wells M, Campbell MJ, Nielsen B et al (1997) Quality of life and patient preference for sequential versus continuous combined HRT: the UK Kliofem multicenter study experience. UK Continuous Combined HRT Study Investigators. Int J Gynaecol Obstet 59(Suppl1):S11–S17
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. JAMA 285:2486–2497
Lobo RA (2008) Metabolic syndrome after menopause and the role of hormones. Maturitas 60:10–18
Pasquali R, Casimirri F, Labate AM, Tortelli O, Pascal G, Anconetani B et al (1994) Body weight, fat distribution and the menopausal status in women. The VMH Collaborative Group. Int J Obes Relat Metab Disord 18:614–621
Thurston RC, Sowers MR, Sutton-Tyrell K, Everson-Rose SA, Lewis TT, Edmundowicz D et al (2008) Abdominal adiposity and hot flashes among midlife women. Menopause 15:429–434
Gast GC, Grobbee DE, Pop VJ, Keyzer JJ, Wijnands-van Gent CJ, Samsioe GN et al (2008) Menopausal complaints are associated with cardiovascular risk factors. Hypertension 51:1492–1498
Esposito K, Giugliano D (2005) Obesity, the metabolic syndrome, and sexual dysfunction. Int J Impot Res 17:391–398
Laudisio A, Marzetti E, Pagano F, Bernabei R, Zuccala G (2009) Depressive symptoms and metabolic syndromes: selective association in older women. J Geriatr Psychiatry Neurol 22:215–222
Hauser GA, Huber IC, Keller PJ, Lauritzen C, Schneider HP (1994) Evaluation of climacteric symptoms (Menopause Rating Scale). Zentralbl Gynakol 116:16–23
Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F et al (2004) Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 364:937–952
Alberti KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15:539–553
Krotkiewski M, Bjorntorp P, Sjostrom L, Smith U (1983) Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution. J Clin Invest 72:1150–1162
Lee CG, Carr MC, Murdich SJ, Mitchell E, Woods NF, Wener MH et al (2009) Adipokines, inflammation, and visceral adiposity across the menopausal transition: a prospective study. J Clin Endocrinol Metab 94:1104–1110
Poehlman ET, Toth MJ, Gardner AW (1995) Changes in energy balance and body composition at menopause: a controlled longitudinal study 123:673–675
Grodstein F, Manson JE, Colditz GA, Willett WC, Speizer FE, Stampfer MJ (2000) A prospective, observational study of postmenopausal hormone therapy and primary prevention of cardiovascular disease. Ann Intern Med 133:933–941
Rossouw JE, Prentice RL, Manson JE, Wu L, Barad D, Bamabei VM et al (2007) Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. JAMA 297:1465–1477
Chedraui P, Hidalgo L, Chavez D, Morocho N, Alvarado M, Huc A (2007) Menopausal symptoms and associated risk factors among postmenopausal women screened for the metabolic syndrome. Arch Gynecol Obstet 275:161–168
Fernandez-Alonso AM, Cuadros JL, Chedraui P, Mendoza M, Cuadros AM, Perez-Lopez FR (2010) Obesity is related to increased menopausal symptoms among Spanish women. Menopause Int 16:105–110
Freedman RR (2005) Pathophysiology and treatment of menopausal hot flashes. Semin Reprod Med 23:117–125
Erlik Y, Meldrum DR, Judd HL (1982) Estrogen levels in postmenopausal women with hot flashes. Obstet Gynecol 59:403–407
Otte JW, Merrick MA, Ingersoll CD, Cordova ML (2002) Subcutaneous adipose tissue thickness alters cooling time during cryotherapy. Arch Phys Med Rehabil 83:1501–1505
Thurston RC, Sutton-Tyrrell K, Everson-Rose SA, Hess R, Matthews KA (2008) Hot flashes and subclinical cardiovascular disease: findings from the Study of Women’s Health Across the Nation Heart Study. Circulation 118(12):1234–1240
Temml C, Obermayr R, Marszalek M, Rauchenwald M, Madersbacher S, Ponholzer A (2009) Are lower urinary tract symptoms influenced by metabolic syndrome? Urology 73(3):544–548
Ponholzer A, Temml C, Rauchenwald M, Marszalek M, Madersbacher S (2008) Is metabolic syndrome a risk factor for female sexual dysfunction in sexually active women? Int J Impot Res 20:100–104
Skilton MR, Moulin P, Terra JL, Bonnet F (2007) Association between anxiety, depression, and the metabolic syndrome. Biol Psychiatry 62:1251–1257
Hildrum B, Mykletun A, Midrthjell K, Ismail K, Dahl AA (2009) No association of depression and anxiety with the metabolic syndrome: the Norwegian HUNT study. Acta Psychiatr Scand 120:14–22
Nagai M, Komiya H, Mori Y, Ohta T, Kasahara Y, Ikeda Y (2010) Estimating visceral fat area by multifrequency bioelectrical impedance. Diabetes Care 33:1077–1079
Conflict of interest
None.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Lee, S.W., Jo, H.H., Kim, M.R. et al. Association between menopausal symptoms and metabolic syndrome in postmenopausal women. Arch Gynecol Obstet 285, 541–548 (2012). https://doi.org/10.1007/s00404-011-2016-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00404-011-2016-5