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RETRACTED ARTICLE: Laparoscopic ovarian diathermy after clomiphene failure in polycystic ovary syndrome: is it worthwhile? A randomized controlled trial

  • Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

This article was retracted on 29 March 2023

This article has been updated

Abstract

Purpose

Laparoscopic ovarian diathermy (LOD) represents a successful treatment option for women with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS). However, in case of CC failure PCOS, LOD offers several theoretical advantages. This study was conducted to compare the efficacy of LOD versus continuation of CC up to six further cycles in PCOS patients who failed to achieve pregnancy despite the previous successful CC induced ovulation.

Methods

One hundred and seventy six infertile women with CC failure PCOS were selected in this randomized controlled trial. Patients (n = 87) underwent LOD with 6 months follow-up or received CC (n = 89) up to six cycles. Outcome measures were; clinical pregnancy rate, midcycle endometrial thickness, cycle length, miscarriage and live birth rates.

Results

The clinical pregnancy rate per patient and the cumulative pregnancy rate after six cycles were comparable in both groups (39 vs. 33.7% and 47 vs. 39.2%, respectively). Four twin pregnancies occurred in CC group and none in LOD group and the difference was statistically significant (p < 0.05). No significant difference in midcycle endometrial thickness was observed (8.8 ± 1.2 mm vs. 7.7 ± 1.1 mm). Improvement in cycle length, miscarriage and live birth rates were comparable in both groups. No cases of ovarian hyperstimulation syndrome occurred in either group.

Conclusions

LOD during the 6 months follow-up period and CC for up to six further cycles are equally effective for achieving pregnancy in CC failure PCOS patients.

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Acknowledgments

The authors would like to thank Dr. M. Bazeed MD, Ass. Prof. and consultant of Diagnostic Radiology, Mansoura Faculty of Medicine, Mansoura University Hospitals, for his invaluable effort doing transvaginal ultrasound assessment and follow-up of patients enabling completion of this trial report.

Conflict of interest

We declare that we have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Obstetrics & Gynecology, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt

    Hatem Abu Hashim

  2. Department of Internal Medicine, Endocrinology Unit, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt

    Osama Foda

  3. Department of Clinical Pharmacology, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt

    Essam Ghayaty

  4. Department of Clinical Pathology, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt

    Ahmed Elawa

Authors
  1. Hatem Abu Hashim
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  2. Osama Foda
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  3. Essam Ghayaty
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  4. Ahmed Elawa
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Corresponding author

Correspondence to Hatem Abu Hashim.

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Abu Hashim, H., Foda, O., Ghayaty, E. et al. RETRACTED ARTICLE: Laparoscopic ovarian diathermy after clomiphene failure in polycystic ovary syndrome: is it worthwhile? A randomized controlled trial. Arch Gynecol Obstet 284, 1303–1309 (2011). https://doi.org/10.1007/s00404-011-1983-x

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  • DOI: https://doi.org/10.1007/s00404-011-1983-x

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