Skip to main content
Log in

Prenatal ultrasound and histological diagnosis of fetal nasal glioma (heterotopic central nervous system tissue): report of a new case and review of the literature

  • Short Communication
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Introduction

Nasal glioma is a rare, benign congenital midline facial lesion.

Materials and methods

Prenatal ultrasound diagnosis performed at 2nd trimester of pregnancy revealed a right-sided mass at the level of the fetal face extending from the right internal canthus to the nasal bridge.

Conclusion

Differential diagnosis of facial mass in the fetus represents a critical issue because is essential in guiding the prenatal counselling of the couple and in guiding the prenatal and/or postnatal management. Alternative diagnoses such as dacryocystocele, dermoid cyst, retinoblastoma or teratoma, hemangioma, and encephalocele that can not completely be excluded prenatally are discussed. Embryology, pathology, prenatal ultrasound diagnostic clusters of the lesion as well as MR imaging findings are discussed together with review of the literature.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

References

  1. Strauss RB, Callicott JH, Hargett IR (1966) Intranasal heterotopia. So-called nasal glioma. Am J Dis Child 111:317–320

    PubMed  CAS  Google Scholar 

  2. Fletcher C (ed) (2007) Diagnostic Histopathology of Tumors. 3rd edn. vol 1. Chapt 4. Churchill Livingstone Elsevier, Philadelphia, p 135

  3. Riffaud L, Ndikumana R, Azzis O, Cadre B (2008) Glial heterotipia of the face. J Pediatr Surg 43:e1–e3

    Article  PubMed  Google Scholar 

  4. De Biasio P, Scarso E, Prefumo F, Odella C, Rossi A, Venturini PL (2006) Prenatal diagnosis of a nasal glioma in the mid trimester. Ultrasound Obstet Gynecol 27:571–573

    Article  PubMed  Google Scholar 

  5. Grzegorezyk V, Brausser-Daudruy M, Labadie G, Cellier C, Verspyck E (2010) Prenatal diagnosis of a nasal glioma. Pediatr Radiol. doi:10.1007/s00247-010-1642-6

  6. Chmait RH, Pretorius DH, Hull AD (2002) Picture of the month. Ultrasound Obstet Gynecol 20:417–418

    Article  PubMed  CAS  Google Scholar 

  7. Charrier JB, Leboulanger N, Roger G, Denoyelle F, Garabédian EN, Monteil JP (2006) Nasal glioma heterotopia: embryological and clinical approaches. Rev Stomatol Chir Maxillofac 107:44–49

    Article  PubMed  Google Scholar 

  8. Fitzpatrick E, Miller RH (1996) Congenital midline masses: dermoids, gliomas, and encephaloceles. J State Med Soc 148:93–96

    CAS  Google Scholar 

  9. Maat-Kievit JA, Oepkes D, Hartwig NG, Vermeij-Keers C, van Kamp IL, van de Kamp JJ (1993) A large retinoblastoma detected in a fetus at 21 weeks of gestation. Prenat Diagn 13:377–384

    Article  PubMed  CAS  Google Scholar 

  10. Sepulveda W, Wojakowski AB, Elias D, Otaño L, Gutierrez J (2005) Congenital dacryocystocele. Prenatal 2- and 3-dimensional sonographic findings. J Ultrasound Med 24:225–230

    PubMed  Google Scholar 

  11. Sharony R, Raz J, Aviram R, Cohen I, Beyth Y, Tepper T (1999) Prenatal diagnosis of dacryocystocele: a possible marker for syndrome. Ultrasound Obstet Gynecol 14:71–73

    Article  PubMed  CAS  Google Scholar 

  12. Castillo M (1994) Congenital abnormalities of the nose: CT and MR findings. AJR 162:1211–1217

    PubMed  CAS  Google Scholar 

  13. Benacerraf BR (1999) A nasal tip teratoma. Ultrasound Obstet Gynecol 14:222

    Article  PubMed  CAS  Google Scholar 

  14. Dasgupta NR, Bentz ML (2003) Nasal gliomas: identification and differentiation from hemangiomas. J Craniofac Surg 14:736–738

    Article  PubMed  Google Scholar 

  15. Bronshtein M, Bar-Hava I, Blumenfeld Z (1992) Early second-trimester sonographic appearance of occipital hemangioma simulating encephalocele. Prenat Diagn 12:695–698

    Article  PubMed  CAS  Google Scholar 

  16. Gorincour G, Kokta V, Rypens F, Garel L, Powell J, Dubois J (2005) Imaging characteristics of two subtypes of congenital hemangiomas: rapidly involuting congenital hemangiomas and non-involving congenital hemangiomas. Pediatr Radiol 35:1178–1185

    Article  PubMed  Google Scholar 

  17. Elia D, Garel C, Enjolras O, Vermouneix L, Soupre V, Oury JF, Guibaud L (2008) Prenatal imaging findings in rapidly involuting congenital hemangioma of the skull. Ultrasound Obstet Gynecol 31:572–575

    Article  PubMed  CAS  Google Scholar 

  18. Wu CL, Tsao LY, Yang AD, Chen MK (2008) Endoscopic surgery for nasal glioma mimicking encephalocele in infancy. Skull Base 18:401–404

    Article  PubMed  Google Scholar 

  19. Park YH, Kim SW, Cho SH, Choi YW (2010) Nasopharyngeal glioma causing respiratory distress in a neonate: transoral endoscopic excision. Ear Nose Throat 89:E11–E13

    Google Scholar 

  20. Cerdá-Nicolá M, Sanchez Fernandez de Sevilla C, Lopez-Ginés C, Peydro-Olaya A, Llombart-Bosch A (2002) Nasal glioma or nasal glial heterotopia? Morphological, immunohistochemical and ultrastructural study of two cases. Clin Neuropathol 21:66–71

    Google Scholar 

  21. Huisman TA, Schneider JF, Kellenberger CJ, Martin-Fiori E, Willi UV, Holzman D (2004) Developmental nasal midline masses in children: neuroradiological evaluation. Eur Radiol 14:243–249

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Gabriele Tonni.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tonni, G., Lituania, M., Bonasoni, M.P. et al. Prenatal ultrasound and histological diagnosis of fetal nasal glioma (heterotopic central nervous system tissue): report of a new case and review of the literature. Arch Gynecol Obstet 283 (Suppl 1), 55–59 (2011). https://doi.org/10.1007/s00404-011-1856-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-011-1856-3

Keywords

Navigation