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Effects of elm bark extracts from Ulmus laevis on human chorion carcinoma cell lines

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

The potential of substances from elm bark extracts to affect cancer has been described in several studies. In this study, the anticancer effects of extracts from Ulmus laevis bark were tested in hormone-dependent gynecological tumours using human chorion carcinoma cell lines.

Methods

The molecular-chemical composition of the bark extract was analysed by pyrolysis-field ionisation mass spectrometry. The influence of the extracts was determined on cell vitality and cytotoxicity in the human chorion carcinoma cell lines Jeg3 and BeWo in comparison with primary trophoblast cells.

Results

The elm bark extract was mainly composed of triterpenes, phytosterols, free fatty acids and suberins with lower amounts of dilignols and lipids. The elm bark extract significantly inhibited the vitality of Jeg3 and BeWo cells but increased the vitality of primary trophoblast cells.

Conclusions

Substances extracted from elm bark might have beneficial effects for the prevention of hormone-dependent tumours.

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Abbreviations

MTT:

3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide

LDH:

Lactate dehydrogenase

E:

17-β-estradiol

T:

Tamoxifen

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Acknowledgments

The authors thank Mrs. C.Bauer and Mrs. E.Greschkowitz for technical assistance. Sincere thanks are due to Prof. Porembski for identification of the elm bark from Ulmus laevis. Py-FIMS analyses were partly supported by the “Exzellenzförderprogramm” of the Ministerium für Bildung, Wissenschaft und Kultur Mecklenburg-Western Pomerania, project UR 07 079.

Conflict of interest

None.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Faculty of Medicine, University of Rostock, Südring 81, 18059, Rostock, Germany

    Anna-Maria Hartmann, Dagmar-Ulrike Richter & Volker Briese

  2. Department of Biochemistry, Faculty of Natural Sciences, Institute of Biological Sciences, University of Rostock, Albert-Einstein-Strasse 3, 18059, Rostock, Germany

    Sibylle Abarzua

  3. Institute for Land-Use, Faculty of Agricultural and Environmental Sciences, University of Rostock, Justus-von-Liebig-Weg 6, 18059, Rostock, Germany

    André Schlichting & Peter Leinweber

Authors
  1. Anna-Maria Hartmann
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  2. Sibylle Abarzua
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  3. André Schlichting
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  4. Dagmar-Ulrike Richter
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  5. Peter Leinweber
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  6. Volker Briese
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Corresponding author

Correspondence to Sibylle Abarzua.

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Hartmann, AM., Abarzua, S., Schlichting, A. et al. Effects of elm bark extracts from Ulmus laevis on human chorion carcinoma cell lines. Arch Gynecol Obstet 284, 1265–1269 (2011). https://doi.org/10.1007/s00404-010-1830-5

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  • DOI: https://doi.org/10.1007/s00404-010-1830-5

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